Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Paul D McDonagh"'
Autor:
Heming Xing, Paul D McDonagh, Jadwiga Bienkowska, Tanya Cashorali, Karl Runge, Robert E Miller, Dave Decaprio, Bruce Church, Ronenn Roubenoff, Iya G Khalil, John Carulli
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 3, p e1001105 (2011)
Tumor necrosis factor α (TNF-α) is a key regulator of inflammation and rheumatoid arthritis (RA). TNF-α blocker therapies can be very effective for a substantial number of patients, but fail to work in one third of patients who show no or minimal
Externí odkaz:
https://doaj.org/article/d80bf7a0804f4a0aad4ebd11b36730c2
Autor:
Mary Meskell, Tessa Williams, Alison Frith, Klaus Schmitz-Abe, Calum Yacoubian, Paul D. McDonagh, Catherine A. Brownstein, Andrew Brown, Pankaj B. Agrawal, Shira Rockowitz, Alan H. Beggs, Asli Aykanat, Andrew Quitadomo, John Reynders, Thomas Defay, Sebastien Lefebvre, Jignesh R. Parikh, Casie A. Genetti, Richard Gain, Jill A. Madden, Piotr Sliz, Morgan Danowski
Publikováno v:
HGG Advances, Vol 2, Iss 3, Pp 100035-(2021)
HGG advances
HGG advances
Summary: Effective genetic diagnosis requires the correlation of genetic variant data with detailed phenotypic information. However, manual encoding of clinical data into machine-readable forms is laborious and subject to observer bias. Natural langu
Autor:
Terence C. Wong, Marie L. Janes, John Reynders, Martin G. Reese, Brett Williams, Patrick Mulrooney, Sergey Batalov, Kristen Wigby, Brandon Camp, Lauge Farnaes, Joshua J.A. Braun, Meredith S. Wright, Narayanan Veeraraghavan, Jeremy Gore, Shareef Nahas, David Dimmock, Sheldon Gilmer, Lisa Salz, Albert Oriol, Mari Tokita, Kejia Lin, Thomas Defay, Erica Sanford, Catherine Yamada, Nathaly M. Sweeney, Stephen F. Kingsmore, Yan Ding, Christina Clarke, Laura Puckett, Katarzyna A. Ellsworth, Richard Gain, Shauna George, Luca Van Der Kraan, Margaret Bray, Mary Gaughran, Curtis Beebe, Alison Frith, Kevin Hall, Kyle McBride, Amber Hildreth, Michelle M. Clark, Haiying Li Grunenwald, Julie Ryu, Cyrielle Kint, Kelly Watkins, Mitchell Creed, Jennifer Friedman, Shimul Chowdhury, Paul D. McDonagh, Zia Rady, Peter Schols, Joseph G. Gleeson, Julie A. Cakici, Lawrence Stewart, Raymond Hovey, Jeanne Carroll, Matthew N. Bainbridge, Daeheon Oh, Calum Yacoubian, Sara A. Caylor, Sarah White
Publikováno v:
Science translational medicine. 11(489)
By informing timely targeted treatments, rapid whole-genome sequencing can improve the outcomes of seriously ill children with genetic diseases, particularly infants in neonatal and pediatric intensive care units (ICUs). The need for highly qualified
Autor:
Heidi S. Feiler, Rina Gendelman, Heming Xing, Olga K. Mirzoeva, Christina Curtis, Paul D. McDonagh, Preeti Sarde, Iya Khalil, W. Michael Korn, Joe W. Gray
Publikováno v:
Cancer research, vol 77, iss 7
Molecular networks governing responses to targeted therapies in cancer cells are complex dynamic systems that demonstrate nonintuitive behaviors. We applied a novel computational strategy to infer probabilistic causal relationships between network co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b55871d62dd711c4aa235e1c548c529
https://escholarship.org/uc/item/0m02v1r8
https://escholarship.org/uc/item/0m02v1r8
Autor:
Ira Shoulson, Iya Khalil, Bernard Ravina, Anthony E. Lang, Kenneth Marek, Jason M. Laramie, Boris Hayete, Shirley Eberly, Andrew B. Singleton, Diane Wuest, Karl Runge, Bruce W. Church, Ajay Verma, Caroline M. Tanner, Paul D. McDonagh
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178982 (2017)
PloS one, vol 12, iss 6
PLoS ONE
PloS one, vol 12, iss 6
PLoS ONE
Background There are few established predictors of the clinical course of PD. Prognostic markers would be useful for clinical care and research. Objective To identify predictors of long-term motor and cognitive outcomes and rate of progression in PD.
Autor:
Amelia Bartholomew, Paul C. LaStayo, Karyn A. Esser, Stan L. Lindstedt, Phyllis Napoles, Dani Lipovic, Paul D. McDonagh
Publikováno v:
Journal of Geriatric Physical Therapy. 30:128-134
Elderly individuals participate in resistance exercise to induce an anabolic response and grow muscle to help overcome functional deficits. It is thought that a muscle damage and inflammatory response to resistance exercise is a necessary prerequisit
Publikováno v:
Nucleic Acids Research. 28:2800-2803
The complete chromosomal sequence for chromosome 1 from Leishmania major Friedlin predicts that this chromosome has 79 protein-coding genes. Surprisingly, the first 29 of these genes are encoded in tandem on one strand of DNA, and the remaining 50 ge
Publikováno v:
Biochemical Journal. 343:525-531
Glutathione S-transferases (GSTs) play a key role in the metabolism of drugs and xenobiotics. To investigate the catalytic mechanism, substrate binding and catalysis by the wild-type and two mutants of GST A1-1 have been studied. Substitution of the
Autor:
John P. Carulli, Heming Xing, Karl Runge, Tanya Cashorali, Jadwiga Bienkowska, Bruce Church, David DeCaprio, Robert E. Miller, Ronenn Roubenoff, Iya Khalil, Paul D. McDonagh
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 7, Iss 3, p e1001105 (2011)
PLoS Computational Biology, Vol 7, Iss 3, p e1001105 (2011)
Tumor necrosis factor α (TNF-α) is a key regulator of inflammation and rheumatoid arthritis (RA). TNF-α blocker therapies can be very effective for a substantial number of patients, but fail to work in one third of patients who show no or minimal
Autor:
Santiago Martínez-Calvillo, Susan M. Sunkin, Rentala Madhubala, Deborah E. Dobson, Shaofeng Yan, Alka Saxena, Kenneth Stuart, Alasdair C. Ivens, Paul D. McDonagh, Jeronimo C. Ruiz, Ellen Sisk, Stephen M. Beverley, Angela K. Cruz, Elizabeth A. Worthey, Peter J. Myler
Publikováno v:
Medical microbiology and immunology. 190(1-2)
The sequencing of Leishmania major Friedlin chromosome 1 (Chr1), Chr3, and Chr4 has been completed. and several other chromosomes are well underway. The complete genome sequence should be available by 2003. Over 1,000 full-length new genes have been