Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Paul D Kaufman"'
Autor:
Pradeep Kumar, Omid Gholamalamdari, Yang Zhang, Liguo Zhang, Anastassiia Vertii, Tom van Schaik, Daan Peric-Hupkes, Takayo Sasaki, David M. Gilbert, Bas van Steensel, Jian Ma, Paul D. Kaufman, Andrew S. Belmont
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-18 (2024)
Abstract Genome differential positioning within interphase nuclei remains poorly explored. We extended and validated Tyramide Signal Amplification (TSA)-seq to map genomic regions near nucleoli and pericentric heterochromatin in four human cell lines
Externí odkaz:
https://doaj.org/article/cfb961e8f2924eb693d3f3d3481fa6c4
Publikováno v:
eLife, Vol 7 (2018)
Nucleosomes contain two copies of each core histone, held together by a naturally symmetric, homodimeric histone H3-H3 interface. This symmetry has complicated efforts to determine the regulatory potential of this architecture. Through molecular desi
Externí odkaz:
https://doaj.org/article/9be9c360ae92411bac940a16952a3235
Autor:
Yuichi Ichikawa, Caitlin F Connelly, Alon Appleboim, Thomas CR Miller, Hadas Jacobi, Nebiyu A Abshiru, Hsin-Jung Chou, Yuanyuan Chen, Upasna Sharma, Yupeng Zheng, Paul M Thomas, Hsuiyi V Chen, Vineeta Bajaj, Christoph W Müller, Neil L Kelleher, Nir Friedman, Daniel NA Bolon, Oliver J Rando, Paul D Kaufman
Publikováno v:
eLife, Vol 6 (2017)
The repeating subunit of chromatin, the nucleosome, includes two copies of each of the four core histones, and several recent studies have reported that asymmetrically-modified nucleosomes occur at regulatory elements in vivo. To probe the mechanisms
Externí odkaz:
https://doaj.org/article/24b6ece5ed4441b78cfba5f0e8e8b723
Autor:
Eric Campeau, Victoria E Ruhl, Francis Rodier, Corey L Smith, Brittany L Rahmberg, Jill O Fuss, Judith Campisi, Paul Yaswen, Priscilla K Cooper, Paul D Kaufman
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6529 (2009)
The ability to express or deplete proteins in living cells is crucial for the study of biological processes. Viral vectors are often useful to deliver DNA constructs to cells that are difficult to transfect by other methods. Lentiviruses have the add
Externí odkaz:
https://doaj.org/article/4f722a938c074f44af58f8c1f007f6a7
Autor:
Tommy Kaplan, Chih Long Liu, Judith A Erkmann, John Holik, Michael Grunstein, Paul D Kaufman, Nir Friedman, Oliver J Rando
Publikováno v:
PLoS Genetics, Vol 4, Iss 11, p e1000270 (2008)
Acetylation of histone H3 lysine 56 is a covalent modification best known as a mark of newly replicated chromatin, but it has also been linked to replication-independent histone replacement. Here, we measured H3K56ac levels at single-nucleosome resol
Externí odkaz:
https://doaj.org/article/794b2f9fa1af4936b168527a3a1657ab
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36(11)
This conference brought together leaders in the investigation of various bodies that populate the nucleus, a field that complements research on chromosome biology. These nuclear bodies had been receiving increasing attention as hubs of genome activit
Autor:
Yuichi Ichikawa, Paul D. Kaufman
Publikováno v:
Current Genetics. 65:371-377
In eukaryotes, genomic DNA is packaged into the nucleus together with histone proteins, forming chromatin. The fundamental repeating unit of chromatin is the nucleosome, a naturally symmetric structure that wraps DNA and is the substrate for numerous
Autor:
Paul D. Kaufman, Xiaoming Sun
Publikováno v:
Chromosoma. 127:175-186
Ki-67 protein has been widely used as a proliferation marker for human tumor cells for decades. In recent studies, multiple molecular functions of this large protein have become better understood. Ki-67 has roles in both interphase and mitotic cells,
Publikováno v:
Chromosoma
BackgroundHeterochromatin in eukaryotic interphase cells frequently localizes to the nucleolar periphery (nucleolus-associated domains, NADs) and the nuclear lamina (lamina-associated domains, LADs). Gene expression in somatic cell NADs is generally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0d18056a9dbedd340465642b7de0d4
https://doi.org/10.1101/740480
https://doi.org/10.1101/740480
Autor:
Anastassiia Vertii, Hervé Pagès, Lihua Julie Zhu, Jianhong Ou, Aimin Yan, Haibo Liu, Paul D. Kaufman, Jun Yu
In interphase eukaryotic cells, almost all heterochromatin is located adjacent to the nucleolus or to the nuclear lamina, thus defining Nucleolus-Associated Domains (NADs) and Lamina–Associated Domains (LADs), respectively. Here, we determined the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a3b61fecb37e0a76ff082a3d575e90