Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Paul D Hoeprich"'
Autor:
Matthew A Coleman, Jenny A Cappuccio, Craig D Blanchette, Tingjuan Gao, Erin S Arroyo, Angela K Hinz, Feliza A Bourguet, Brent Segelke, Paul D Hoeprich, Thomas Huser, Ted A Laurence, Vladimir L Motin, Brett A Chromy
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150166 (2016)
Yersinia pestis enters host cells and evades host defenses, in part, through interactions between Yersinia pestis proteins and host membranes. One such interaction is through the type III secretion system, which uses a highly conserved and ordered co
Externí odkaz:
https://doaj.org/article/ce20e916630041188cd3ee34a7e0cc71
Autor:
Nicholas O Fischer, Craig D Blanchette, Brent W Segelke, Michele Corzett, Brett A Chromy, Edward A Kuhn, Graham Bench, Paul D Hoeprich
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11643 (2010)
BACKGROUND: Nanolipoprotein particles (NLPs) are discoidal, nanometer-sized particles comprised of self-assembled phospholipid membranes and apolipoproteins. NLPs assembled with human apolipoproteins have been used for myriad biotechnology applicatio
Externí odkaz:
https://doaj.org/article/1d466b8345694c71834ad82dacff380c
Autor:
Dina R. Weilhammer, Alexis D. Dunkle, Tyler Boone, Sean F. Gilmore, Mark Khemmani, Sandra K. G. Peters, Paul D. Hoeprich, Nicholas O. Fischer, Craig D. Blanchette, Adam Driks, Amy Rasley
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Subunit vaccines are theoretically safe and easy to manufacture but require effective adjuvants and delivery systems to yield protective immunity, particularly at critical mucosal sites such as the lung. We investigated nanolipoprotein particles (NLP
Externí odkaz:
https://doaj.org/article/ca91e8ee57e54aeda6984465ee70cda7
Autor:
Paul D. Hoeprich, Graham Bench, Brett A. Chromy, Matthew A. Coleman, William Henry Benner, Jenny A. Cappuccio, Edward A. Kuhn, Michele H. Corzett, Nicholas Fischer, Craig D. Blanchette, Brent W. Segelke, Todd A. Sulchek
Publikováno v:
International Journal of Molecular Sciences, Vol 10, Iss 7, Pp 2958-2971 (2009)
Heterogeneity is a fact that plagues the characterization and application of many self-assembled biological constructs. The importance of obtaining particle homogeneity in biological assemblies is a critical goal, as bulk analysis tools often require
Externí odkaz:
https://doaj.org/article/0ee3f4f80c254dcca3b7b483a617bc39
Autor:
Craig D. Blanchette, Richard Law, W. Henry Benner, Joseph B. Pesavento, Jenny A. Cappuccio, Vicki Walsworth, Edward A. Kuhn, Michele Corzett, Brett A. Chromy, Brent W. Segelke, Matthew A. Coleman, Graham Bench, Paul D. Hoeprich, Todd A. Sulchek
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 7, Pp 1420-1430 (2008)
Self-assembly of purified apolipoproteins and phospholipids results in the formation of nanometer-sized lipoprotein complexes, referred to as nanolipoprotein particles (NLPs). These bilayer constructs are fully soluble in aqueous environments and hol
Externí odkaz:
https://doaj.org/article/c73175892234465182736f2559d216dd
Autor:
Nicholas O. Fischer, Paul D. Hoeprich, Craig D. Blanchette, Tyler Boone, Sean F. Gilmore, Sandra K. G. Peters, Adam Driks, Amy Rasley, Alexis Dunkle, Dina R. Weilhammer, Mark Khemmani
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Vol 11 (2020)
Subunit vaccines are theoretically safe and easy to manufacture but require effective adjuvants and delivery systems to yield protective immunity, particularly at critical mucosal sites such as the lung. We investigated nanolipoprotein particles (NLP
Autor:
Alexis Dunkle, Adam Driks, Dina R. Weilhammer, Craig D. Blanchette, Tyler Boone, Amy Rasley, Paul D. Hoeprich, Nicholas O. Fischer, Michele Corzett, Doerte Lehmann
Publikováno v:
Vaccine. 35:1475-1481
To address the need for vaccine platforms that induce robust cell-mediated immunity, we investigated the potential of utilizing self-assembling biologic nanolipoprotein particles (NLPs) as an antigen and adjuvant delivery system to induce antigen-spe
Autor:
Michael Mallozzi, Amy Rasley, Brian M. Thompson, Dörte Lehmann, Adam Driks, Paul D. Hoeprich, George C. Stewart, Mark Khemmani, Alexander Nelson, Tyler Boone, Alexis Dunkle
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
mBio
mBio, Vol 9, Iss 6, p e01166-18 (2018)
mBio
mBio, Vol 9, Iss 6, p e01166-18 (2018)
This work dramatically improves our understanding of the assembly of the outermost layer of the B. anthracis spore, the exosporium, a layer that encases spores from many bacterial species and likely plays important roles in the spore’s interactions
Autor:
Teresa de los Santos, Paul D. Hoeprich, Elizabeth Rieder, Thomas G. Burrage, Luis L. Rodriguez, Fayna Diaz-San Segundo, Devendra K. Rai, Elizabeth A. Schafer
Publikováno v:
Virology. 495:136-147
Here, we engineered two FMD viruses with histidine residues inserted into or fused to the FMDV capsid. Both 6xHis viruses exhibited growth kinetics, plaque morphologies and antigenic characteristics similar to wild-type virus. The 6xHis tag allowed o
Autor:
Nicholas O. Fischer, Michele Corzett, Amy Rasley, Paul D. Hoeprich, Mona H. Hwang, Craig D. Blanchette
Publikováno v:
Journal of the American Chemical Society. 135:2044-2047
Subunit antigen-based vaccines can provide a number of important benefits over traditional vaccine candidates, such as overall safety. However, because of the inherently low immunogenicity of these antigens, methods for colocalized delivery of antige