Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Paul D Burrowes"'
Autor:
Alan Sulpizio, Marena E Minelli, Min Wan, Paul D Burrowes, Xiaochun Wu, Ethan J Sanford, Jung-Ho Shin, Byron C Williams, Michael L Goldberg, Marcus B Smolka, Yuxin Mao
Publikováno v:
eLife, Vol 8 (2019)
Pseudokinases are considered to be the inactive counterparts of conventional protein kinases and comprise approximately 10% of the human and mouse kinomes. Here, we report the crystal structure of the Legionella pneumophila effector protein, SidJ, in
Externí odkaz:
https://doaj.org/article/526ea497678244118ca94ce0c4b7c0ab
Autor:
Johnathan R. Whetstine, Cyril H. Benes, David C. Christiani, Brendon Ladd, Paul d. Burrowes, Carlos Donado, Yang Zhao, Patricia Greninger, Joshua C. Black, Capucine Van Rechem
Supplementary Table 2. Lung cell lines homozygotes for KDM4A SNP-A482 are not enriched for mutations that could be linked to sensitivity to PI3K/mTOR inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151e08a5e290808c46b1f493c5057191
https://doi.org/10.1158/2159-8290.22530278.v1
https://doi.org/10.1158/2159-8290.22530278.v1
Autor:
Johnathan R. Whetstine, Cyril H. Benes, David C. Christiani, Brendon Ladd, Paul d. Burrowes, Carlos Donado, Yang Zhao, Patricia Greninger, Joshua C. Black, Capucine Van Rechem
Supplementary Figure 3. Rapamycin treatment reduces KDM4A protein levels.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0217ed1522568a8100600cc0510e695b
https://doi.org/10.1158/2159-8290.22530287.v1
https://doi.org/10.1158/2159-8290.22530287.v1
Autor:
Johnathan R. Whetstine, Cyril H. Benes, David C. Christiani, Brendon Ladd, Paul d. Burrowes, Carlos Donado, Yang Zhao, Patricia Greninger, Joshua C. Black, Capucine Van Rechem
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f792e04110d996b138b0a16c9765229
https://doi.org/10.1158/2159-8290.22530284.v1
https://doi.org/10.1158/2159-8290.22530284.v1
Autor:
Johnathan R. Whetstine, Cyril H. Benes, David C. Christiani, Brendon Ladd, Paul d. Burrowes, Carlos Donado, Yang Zhao, Patricia Greninger, Joshua C. Black, Capucine Van Rechem
Supplementary Table 3. List of drugs and primary targets used for the study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4b4025b0181cb922f8ecb52092f8a0
https://doi.org/10.1158/2159-8290.22530275.v1
https://doi.org/10.1158/2159-8290.22530275.v1
Autor:
Johnathan R. Whetstine, Cyril H. Benes, David C. Christiani, Brendon Ladd, Paul d. Burrowes, Carlos Donado, Yang Zhao, Patricia Greninger, Joshua C. Black, Capucine Van Rechem
Supplementary Figure 1. KDM4A SNP-A482 (rs586339) correlates with worse outcome in NSCLC patients.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc41aeda1cae93deb23d9c4035d2cd88
https://doi.org/10.1158/2159-8290.22530293
https://doi.org/10.1158/2159-8290.22530293
Autor:
Johnathan R. Whetstine, Cyril H. Benes, David C. Christiani, Brendon Ladd, Paul d. Burrowes, Carlos Donado, Yang Zhao, Patricia Greninger, Joshua C. Black, Capucine Van Rechem
Supplementary Figure 2. KDM4A SNP-A482 associates with increased cellular sensitivity to drugs targeting the mTOR pathway.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9811414ffbe0afcef96860ff7c102826
https://doi.org/10.1158/2159-8290.22530290
https://doi.org/10.1158/2159-8290.22530290
Autor:
Johnathan R. Whetstine, Cyril H. Benes, David C. Christiani, Brendon Ladd, Paul d. Burrowes, Carlos Donado, Yang Zhao, Patricia Greninger, Joshua C. Black, Capucine Van Rechem
Supplementary Table 1. KDM4A SNP-A482 associates with cellular sensitivity to drugs targeting the mTOR pathway.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b6de4b0e0aa66de744b2dc7bd717b5
https://doi.org/10.1158/2159-8290.22530281
https://doi.org/10.1158/2159-8290.22530281
Autor:
Jung-Ho Shin, Marcus B. Smolka, Byron C. Williams, Alan Sulpizio, Michael L. Goldberg, Paul D Burrowes, Yuxin Mao, Ethan J. Sanford, Min Wan, Marena E. Minelli, Xiaochun Wu
Publikováno v:
eLife, Vol 8 (2019)
Pseudokinases are considered to be the inactive counterparts of conventional protein kinases and comprise approximately 10% of the human and mouse kinomes. Here we report the crystal structure of theLegionella pneumophilaeffector protein, SidJ, in co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61adb3cc55f0d89f45c4c1b0f24d9bd4
Autor:
David C. Christiani, Paul d. Burrowes, Carlos Donado, Johnathan R. Whetstine, Yang Zhao, Joshua C. Black, Patricia Greninger, Cyril H. Benes, Brendon Ladd, Capucine Van Rechem
Publikováno v:
Cancer Discovery. 5:245-254
SNPs occur within chromatin-modulating factors; however, little is known about how these variants within the coding sequence affect cancer progression or treatment. Therefore, there is a need to establish their biochemical and/or molecular contributi