CD36-deficient mice are resistant to alcohol- and high-carbohydrate-induced hepatic steatosis[S]

Autor: Robin D. Clugston, Jason J. Yuen, Yunying Hu, Nada A. Abumrad, Paul D. Berk, Ira J. Goldberg, William S. Blaner, Li-Shin Huang

Publikováno v: Journal of Lipid Research, Vol 55, Iss 2, Pp 239-246 (2014)

CD36 is a scavenger receptor with multiple ligands and cellular functions, including facilitating cellular uptake of free fatty acids (FFAs). Chronic alcohol consumption increases hepatic CD36 expression, leading to the hypothesis that this promotes

Externí odkaz: https://doaj.org/article/4a5bd38646eb437fb24884429b3e815a

Postbariatric hypoglycemia: symptom patterns and associated risk factors in the Longitudinal Assessment of Bariatric Surgery study

Autor: Laura E. Fischer, Bruce M. Wolfe, Nora Fino, Miriam R. Elman, David R. Flum, James E. Mitchell, Alfons Pomp, Walter J. Pories, Jonathan Q. Purnell, Mary-Elizabeth Patti, Paul D. Berk, Marc Bessler, Amna Daud, Harrison Lobdell, Jemela Mwelu, Beth Schrope, Akuezunkpa Ude, Jamie Honohan, Michelle Capasso, Ricardo Costa, Greg Dakin, Faith Ebel, Michel Gagner, Jane Hsieh, Gladys Strain, Rita Bowden, William Chapman, Blair Cundiff, Mallory Ball, Emily Cunningham, Lynis Dohm, John Pender, Walter Pories, Jennifer Barker, Michael Howell, Luis Garcia, Kathy Lancaster, Erika Lovaas, Tim Monson, Chelsea Cassady, Emily Coburn, Emily Moher, Clifford Deveney, Katherine Elder, Stefanie Greene, Jonathan Purnell, Robert O’Rourke, Chad Sorenson, Emma Patterson, William Raum, Lisa VanDerWerff, Jason Kwiatkowski, Anita P. Courcoulas, William Gourash, Carol A. McCloskey, Ramesh Ramanathan, Melissa Kalarchian, Marsha Marcus, Eleanor Shirley, Angela Turo, E. Patchen Dellinger, Saurabh Khandelwal, Skye D. Stewart, Morgan M. Cooley, Rebecca Blissell, Megan J. Miller, Richard Thirlby, Lily Chang, Jeffrey Hunter, Ravi Moonka, Debbie Ng, Steven H. Belle, Wendy C. King, Debbie Martin, Rocco Mercurio, Abdus Wahed, Frani Averbach, Mary Horlick, Carolyn W. Miles, Myrlene A. Staten, Susan Z. Yanovski, David E. Kleiner

Publikováno v: Surg Obes Relat Dis

Background Postbariatric hypoglycemia (PBH) can be a devastating complication for which current therapies are often incompletely effective. More information is needed regarding frequency, incidence, and risk factors for PBH. Objectives To examine hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35495b5341753ffa654bbe4dc4a2281f
https://pubmed.ncbi.nlm.nih.gov/34294589

Nonalcoholic Fatty Liver Disease

Autor: Elizabeth C. Verna, Paul D. Berk

Publikováno v: Clinics in Liver Disease. 20:245-262

Obesity and its major comorbidities, including type 2 diabetes mellitus, nonalcoholic fatty liver disease (NAFLD), obesity cardiomyopathy, and certain cancers, have caused life expectancy in the United States to decline in recent years. Obesity is th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1966c47ba7d7a3cf5ab4bc735006c3cd
https://doi.org/10.1016/j.cld.2015.10.007

Facilitated long chain fatty acid uptake by adipocytes remains upregulated relative to BMI for more than a year after major bariatric surgical weight loss

Autor: Aku Ude-Welcome, Dieunine Anglade, Alfons Pomp, Fengxia Ge, William B. Inabnet, Mehyar Hefazi Torghabeh, Chunguang Hu, José L. Walewski, Harrison Lobdell, Gregory Dakin, Shengli Zhou, Faith Ebel, Marc Bessler, Paul D. Berk, Beth Schrope, Tianshu Feng, Elektra Carras-Terzian

Publikováno v: Obesity. 24:113-122

Objective This study examined whether changes in adipocyte long chain fatty acid (LCFA) uptake kinetics explain the weight regain increasingly observed following bariatric surgery. Methods Three groups (10 patients each) were studied: patients withou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c96efd46ed2bfff1170c7040ce3d98c
https://doi.org/10.1002/oby.21249

Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity

Autor: Paul D. Berk, José L. Walewski, Fengxia Ge, Gregory Dakin, Harrison Lobdell, Gary J. Schwartz, Joseph R. Vasselli, Nancy Levin, Afons Pomp

Publikováno v: Obesity. 22:1643-1652

Objective Microarray studies identified Ch12:orf39 (Spexin) as the most down-regulated gene in obese human fat. Therefore, we examined its role in obesity pathogenesis. Methods Spexin effects on food intake, meal patterns, body weight, respiratory ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4afca140408ebed49346d7a1d1bbb323
https://doi.org/10.1002/oby.20725