Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Paul D, Sherrington"'
Autor:
Andrew R. Pettitt, John K. Field, Triantafillos Liloglou, Ke Lin, Anthony Carter, Paul D. Sherrington, Gillian G. Johnson
Supplementary Tables 1-3, Figure 1 from A Novel Type of p53 Pathway Dysfunction in Chronic Lymphocytic Leukemia Resulting from Two Interacting Single Nucleotide Polymorphisms within the p21 Gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3c093afb8d5a8c8c94b1f116d97f05
https://doi.org/10.1158/0008-5472.22377606
https://doi.org/10.1158/0008-5472.22377606
Autor:
Andrew R. Pettitt, John K. Field, Ke Lin, Anthony Carter, Triantafillos Liloglou, Paul D. Sherrington, Gillian G. Johnson
Publikováno v:
Cancer Research. 69:5210-5217
The ATM-p53 pathway plays an important role in the biology of chronic lymphocytic leukemia (CLL). Its functional integrity can be probed by exposing CLL cells to ionizing radiation (IR) and measuring levels of p53 protein and one of its transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dccf39e89d034ca15ad89db79c45bfba
https://doi.org/10.1158/0008-5472.can-09-0627
https://doi.org/10.1158/0008-5472.can-09-0627
Autor:
K Pearson, Daniel Catovsky, Anthony Carter, Anna Burford, Mark Atherton, Andrew R. Pettitt, Estella Matutes, Angela Douglas, Vasantha Brito-Babapulle, Ke Lin, Paul D. Sherrington
Publikováno v:
Leukemia. 20:737-740
Imperfect correlation between p53 dysfunction and deletion of TP53 and ATM in chronic lymphocytic leukaemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0a5ef747f33c19d5f057966aaca84dc
https://doi.org/10.1038/sj.leu.2404120
https://doi.org/10.1038/sj.leu.2404120
Publikováno v:
Leukemia. 19:741-749
Some cellular and molecular features of chronic lymphocytic leukaemia (CLL) cells that are associated with prognosis may reflect the context within which their progenitors encountered antigen. It follows that the nature of antigen drive in CLL could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b90e83c7bbfe878e96ab4194046c73d
https://doi.org/10.1038/sj.leu.2403720
https://doi.org/10.1038/sj.leu.2403720
Publikováno v:
British Journal of Haematology. 127:425-428
In chronic lymphocytic leukaemia (CLL) cells, functional impairment of the p53 pathway is detectable by Western blotting as impaired up-regulation of p21 (a transcriptional target of p53) in response to ionizing radiation (IR). The type A defect is c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6865688eba1cebb5a266eaf7222be9a7
https://doi.org/10.1111/j.1365-2141.2004.05223.x
https://doi.org/10.1111/j.1365-2141.2004.05223.x
Publikováno v:
Oncogene. 23:1911-1921
Chronic lymphocytic leukaemia (CLL) results from the accumulation of apoptosis-resistant clonal B cells that are arrested in G0/G1, and is heterogeneous with respect to clinical outcome. An aggressive form of the disease is identified by an impaired
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbb8537815f2a9b3e49792ef66471219
https://doi.org/10.1038/sj.onc.1207318
https://doi.org/10.1038/sj.onc.1207318
Autor:
Andrew R. Pettitt, Michael Dennis, Paul D. Sherrington, Zoltan Matrai, Ke Lin, John C. Cawley
Publikováno v:
Blood. 100:1404-1409
Established adverse prognostic factors in chronic lymphocytic leukemia (CLL) include CD38 expression, relative lack of IgV(H) mutation, and defects of the TP53 gene. However, disruption of the p53 pathway can occur through mechanisms other than TP53
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01a0dddec137a073c2c48178126e7acd
https://doi.org/10.1182/blood-2001-11-0066
https://doi.org/10.1182/blood-2001-11-0066
Autor:
Paul D. Sherrington, Tatjana Stankovic, A. Malcolm R. Taylor, Grant S. Stewart, Andrew R. Pettitt, John C. Cawley
Publikováno v:
Blood. 98:814-822
The well-established association between TP53 mutations and adverse clinical outcome in a range of human cancers reflects the importance of p53 protein in regulating tumor-cell growth and survival. Although it is theoretically possible for p53 dysfun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71903b0cccc30f0420a10b55805196be
https://doi.org/10.1182/blood.v98.3.814
https://doi.org/10.1182/blood.v98.3.814
Autor:
Stephen D. Griffiths, Robert J. Harris, Paul D. Sherrington, Mirko Zuzel, Andrew R. Pettitt, John C. Cawley, Caroline Schmutz
Publikováno v:
The Journal of Immunology. 164:3887-3893
The role of GM-CSF in B cell (patho)physiology is unclear. Although B cells can respond to GM-CSF, there is controversy concerning the extent to which various resting and activated B cell types can themselves produce this cytokine, and the possibilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b55d77b11e60d7b00362326ce6e95c9
https://doi.org/10.4049/jimmunol.164.7.3887
https://doi.org/10.4049/jimmunol.164.7.3887
Publikováno v:
Clinical & Laboratory Haematology. 12:101-103
The differential leukocyte count (DLC) has been an important semi-quantitative method for describing the leukocyte population as visualized on examination of the peripheral blood film. Evaluation of the DLC was never a diagnostic procedure in its own
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0927ea1607aabc8ce14fc124b96dd125
https://doi.org/10.1111/j.1365-2257.1990.tb01116.x
https://doi.org/10.1111/j.1365-2257.1990.tb01116.x