Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Paul Coupland"'
Autor:
Francesca Giordano, Louise Aigrain, Michael A Quail, Paul Coupland, James K Bonfield, Robert M Davies, German Tischler, David K Jackson, Thomas M Keane, Jing Li, Jia-Xing Yue, Gianni Liti, Richard Durbin, Zemin Ning
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Long-read sequencing technologies such as Pacific Biosciences and Oxford Nanopore MinION are capable of producing long sequencing reads with average fragment lengths of over 10,000 base-pairs and maximum lengths reaching 100,000 base- pairs.
Externí odkaz:
https://doaj.org/article/19ac5c0a91fc44f59fafe58742d4515e
Publikováno v:
BioTechniques, Vol 53, Iss 6, Pp 365-372 (2012)
We have developed a sequencing method on the Pacific Biosciences RS sequencer (the PacBio) for small DNA molecules that avoids the need for a standard library preparation. To date this approach has been applied toward sequencing single-stranded and d
Externí odkaz:
https://doaj.org/article/b215e4d024064e8298a2f38818ba0098
Autor:
Munetomo Takahashi, Tsz Y. So, Kate Williamson, Zhaleh Hosseini, Katarzyna Kania, Michelle Ruhle, Tiffeney Mann, Martijn J. Schujis, Paul Coupland, Dean Naisbitt, Timotheus Y.F. Halim, Paul A. Lyons, Pietro Lio, Klaus Okkenhaug, David J. Adams, Ken G.C. Smith, Duncan I. Jodrell, Michael A. Chapman, James E. D. Thaventhiran
Tissue homeostasis is maintained by the behaviours of lymphocyte clones responding to antigenic triggers in the face of pathogen, environmental, and developmental challenges. Current methodologies for tracking the behaviour of specific lymphocytes id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41e52c41c56409441949bd279e56eaf6
https://doi.org/10.1101/2023.03.16.532070
https://doi.org/10.1101/2023.03.16.532070
Autor:
Zewen Kelvin Tuong, Kevin W. Loudon, Brendan Berry, Nathan Richoz, Julia Jones, Xiao Tan, Quan Nguyen, Anne George, Satoshi Hori, Sarah Field, Andy G. Lynch, Katarzyna Kania, Paul Coupland, Anne Babbage, Richard Grenfell, Tristan Barrett, Anne Y. Warren, Vincent Gnanapragasam, Charlie Massie, Menna R. Clatworthy
Publikováno v:
Cell Reports
Summary The prostate gland produces prostatic fluid, high in zinc and citrate and essential for the maintenance of spermatozoa. Prostate cancer is a common condition with limited treatment efficacy in castration-resistant metastatic disease, includin
Autor:
Josephine Barnes, Aidan T Hanrath, Louis C.S. Gardner, Stijn van Dongen, Anthony J. Rostron, Rik G.H. Lindeboom, Michael D Morgan, Justin Engelbert, Kenneth G. C. Smith, John C. Marioni, Berthold Göttgens, Caroline Wilson, Marko Z Nikolic, Andrew Barr, Zewen K. Tuong, Laura Jardine, Kerstin B Meyer, Eliz Kilich, Paul A Lyons, Elisa Laurenti, Ni Huang, Laura Bergamaschi, Simone Webb, Amada Sanchez-Gonzalez, Jaume Bacardit, Sophie Hambleton, Nusayhah Gopee, Gary Reynolds, Dave Horsfall, Jonathan M. Scott, Aarash Saleh, Nicole Mende, Hamish W King, Karsten Bach, Natsuhiko Kumasaka, Fernando J Calero-Nieto, Vladimir Yu. Kiselev, Sarah A. Teichmann, Sam M. Janes, Rebecca Payne, Kaylee B Worlock, Michael W. Mather, Bayanne Olabi, Muzlifah Haniffa, Rachel A. Botting, A. John Simpson, A Saigal, Angus de Wilton, Menna R. Clatworthy, Katarzyna D. Kania, Paul Coupland, Nicola K. Wilson, Masahiro Yoshida, Chris Duncan, Federica Mescia, Emily Stephenson, Jarmila Stremenova Spegarova, Emma Dann, Ina Schim van der Loeff, Kenneth F Baker, Waradon Sungnak, Elena Prigmore, Jim McGrath, Krzysztof Polanski, Issac Goh, Florian Gothe, Claire Smith, Jonathan Coxhead
The COVID-19 pandemic, caused by SARS coronavirus 2 (SARS-CoV-2), has resulted in excess morbidity and mortality as well as economic decline. To characterise the systemic host immune response to SARS-CoV-2, we performed single-cell RNA-sequencing cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c0b1b468522c0c5b65d5a12538cce0c
https://doi.org/10.1101/2021.01.13.21249725
https://doi.org/10.1101/2021.01.13.21249725
Autor:
C.P. Martinez-Jimenez, E. Lleshi, A. Danese, Maria Colomé-Tatché, M. L. Richter, Paul Coupland, I.K. Deligiannis, Catalina A. Vallejos
Single-cell RNA-seq reveals the role of pathogenic cell populations in development and progression of chronic diseases. In order to expand our knowledge on cellular heterogeneity we have developed a single-nucleus RNA-seq2 method that allows deep cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cff5c100d31c587f17bbbfd033f95df
https://doi.org/10.1101/2020.07.11.193458
https://doi.org/10.1101/2020.07.11.193458
Autor:
Matthew J. Bull, Cerith Jones, Stewart T. Cole, Eshwar Mahenthiralingam, C. Paisey, Gregory L. Challis, Joleen Masschelein, Anthony Vocat, Simon R. Harris, Julian Parkhill, Lijiang Song, Paul Coupland, Isolda Romero-Canelón, Gordon Webster, Matthew Jenner, Matthew Dunn, Ruben C. Hartkoorn, Rebecca Weiser
Publikováno v:
Journal of the American Chemical Society. 139:7974-7981
An antimicrobial activity screen of Burkholderia gladioli BCC0238, a clinical isolate from a cystic fibrosis patient, led to the discovery of gladiolin, a novel macrolide antibiotic with potent activity against Mycobacterium tuberculosis H37Rv. Gladi
Autor:
Josef Wagner, Suzanna C. Francis, Julian Parkhill, Hilary P. Browne, Paul Coupland, Trevor D. Lawley
Publikováno v:
BMC Microbiology
Background Currently, bacterial 16S rRNA gene analyses are based on sequencing of individual variable regions of the 16S rRNA gene (Kozich, et al Appl Environ Microbiol 79:5112–5120, 2013).This short read approach can introduce biases. Thus, full-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177c07e220175d23d9669f06fe652742
Autor:
Adam, Shlien, Brittany B, Campbell, Richard, de Borja, Ludmil B, Alexandrov, Daniele, Merico, David, Wedge, Peter, Van Loo, Patrick S, Tarpey, Paul, Coupland, Sam, Behjati, Aaron, Pollett, Tatiana, Lipman, Abolfazl, Heidari, Shriya, Deshmukh, Na'ama, Avitzur, Bettina, Meier, Moritz, Gerstung, Ye, Hong, Diana M, Merino, Manasa, Ramakrishna, Marc, Remke, Roland, Arnold, Gagan B, Panigrahi, Neha P, Thakkar, Karl P, Hodel, Erin E, Henninger, A Yasemin, Göksenin, Doua, Bakry, George S, Charames, Harriet, Druker, Jordan, Lerner-Ellis, Matthew, Mistry, Rina, Dvir, Ronald, Grant, Ronit, Elhasid, Roula, Farah, Glenn P, Taylor, Paul C, Nathan, Sarah, Alexander, Shay, Ben-Shachar, Simon C, Ling, Steven, Gallinger, Shlomi, Constantini, Peter, Dirks, Annie, Huang, Stephen W, Scherer, Richard G, Grundy, Carol, Durno, Melyssa, Aronson, Anton, Gartner, M Stephen, Meyn, Michael D, Taylor, Zachary F, Pursell, Christopher E, Pearson, David, Malkin, P Andrew, Futreal, Michael R, Stratton, Eric, Bouffet, Cynthia, Hawkins, Peter J, Campbell, Uri, Tabori
Publikováno v:
Nature Genetics. 47:257-262
DNA replication-associated mutations are repaired by two components: polymerase proofreading and mismatch repair. The mutation consequences of disruption to both repair components in humans are not well studied. We sequenced cancer genomes from child
Autor:
Julie E. Russell, Ana Deheer-Graham, Kate S. Baker, Paul Coupland, Martin Day, Hannah McGregor, Alison E. Mather, Julian Parkhill, Gemma C. Langridge, Nicholas R. Thomson
Publikováno v:
Lancet
Summary Background Shigellosis (previously bacillary dysentery) was the primary diarrhoeal disease of World War 1, but outbreaks still occur in military operations, and shigellosis causes hundreds of thousands of deaths per year in developing nations