Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Paul Colville-Nash"'
Publikováno v:
Pharmaceutical Research. 25:2440-2446
Bone morphogenic protein-7 (BMP-7) is a member of the transforming growth factor beta (TGFbeta) superfamily involved in organogenesis. Recent work suggests that BMP-7 can reverse the fibrotic effects of TGFbeta but the underlying mechanism is unknown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a89b63460b2020ab303ca0e183b254
https://doi.org/10.1007/s11095-008-9551-1
https://doi.org/10.1007/s11095-008-9551-1
Publikováno v:
Nephron Experimental Nephrology. 105:e108-e116
Background/Aim: Transforming growth factor beta 1 (TGFβ1) is a fibrokine implicated in the progression of renal fibrosis. Following TGFβ1 receptor activation, a number of signalling pathways are stimulated. This study investigates the role of p38 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a35315a448e66b7749b098a02a792e68
https://doi.org/10.1159/000100492
https://doi.org/10.1159/000100492
Autor:
Nadia Abdel Wahab, Mark E. C. Dockrell, Mysore K Phanish, Paul Colville-Nash, Bruce M. Hendry
Publikováno v:
Biochemical Journal. 393:601-607
In chronic renal diseases, progressive loss of renal function correlates with advancing tubulo-interstitial fibrosis. TGFbeta1-Smad (transforming growth factor-beta1-Sma and Mad protein) signalling plays an important role in the development of renal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a27f409de52cac2da8cf3ee7b5d091
https://doi.org/10.1042/bj20051106
https://doi.org/10.1042/bj20051106
Autor:
Paul Colville-Nash, Ryoichi Fujii, Xiang-Ming Liang, Anne Samsoe Engberg, Hans Erik Hansen, Mysore K. Phanish, Zhihong Liu, Masatoshi Mune, Ioana Niculescu-Duvaz, Shan Chen, Kerstin Amann, Gabor Kokeny, Caihong Zeng, Hua Sun, Jan Krtil, Eberhard Ritz, Donata Cibulskyte, M. Madsen, Marcin Adamczak, Jens Tølbøll Mortensen, Leishi Li, Qin Zhou, Jing-min Zheng, Niels Marcussen, Allan Flyvbjerg, Peter Liptak, Marie-Luise Gross, Yoshinori Tone, Michael Pedersen, Arne Hoerlyck, Daniel Hanefelt Kristensen, Anne Ringer Ellingsen, Péter Hamar, Tadao Akizawa, Susumu Yukawa, Mark E. C. Dockrell, Haruhisa Otani
Publikováno v:
Nephron Experimental Nephrology. 105:e139-e141
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67beb564caef127d3d00fe130b9f557e
https://doi.org/10.1159/000101446
https://doi.org/10.1159/000101446
Publikováno v:
InflammoPharmacology. 9:125-130
Acute inflammatory reactions are usually self-limiting and resolve quite rapidly with complete removal of the injurious agent and little incidence of tissue damage. Chronic inflammatory reactions, on the other hand, fail to resolve and persist for lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4187bf1bfbbaae883dd45754f1a3876
https://doi.org/10.1163/156856001300248399
https://doi.org/10.1163/156856001300248399
Autor:
Paul Colville-Nash, Derek W. Gilroy
Publikováno v:
BioDrugs. 15:1-9
Cyclooxygenase (COX; prostaglandin H synthase, prostaglandin endoperoxidase) is the key enzyme in the synthesis of the prostaglandin and thromboxane families of eicosanoid mediators, and is the target for the nonsteroidal anti-inflammatory drugs (NSA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71fdeb1f36f2c6bf4b987aa4d4ee11c6
https://doi.org/10.2165/00063030-200115010-00001
https://doi.org/10.2165/00063030-200115010-00001
Autor:
Paul Colville-Nash, Derek W. Gilroy
Publikováno v:
Prostaglandins & Other Lipid Mediators. 62:33-43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbecfa7ddb717514831d35d2c02af558
https://doi.org/10.1016/s0090-6980(00)00074-5
https://doi.org/10.1016/s0090-6980(00)00074-5
Autor:
Derek W. Gilroy, Paul Colville-Nash
Publikováno v:
Journal of Molecular Medicine. 78:121-129
Cyclo-oxygenase (COX) is responsible for the synthesis of bioactive prostanoids, the inhibition of which serves as the basis for the mode of action of clinically used nonsteroidal anti-inflammatory drugs. While there were suggestions as early as the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70059ea1544c19a9749dd848fca081e1
https://doi.org/10.1007/s001090000094
https://doi.org/10.1007/s001090000094
Autor:
Derek A. Willoughby, Mark J. Paul-Clark, Derek W. Gilroy, Paul Colville-Nash, J. Chivers, Dean Willis
Publikováno v:
Nature Medicine. 5:698-701
Cyclooxygenase (COX) has two isoforms. Generally, COX 1 is constitutively expressed in most tissues, where it maintains physiological processes; inducible COX 2 is considered a pro-inflammatory enzyme and a chief target for the treatment of inflammat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12dccffae8c7f820ce2d28f3a47e95ab
https://doi.org/10.1038/9550
https://doi.org/10.1038/9550
Autor:
K. J. Greenslade, Paul Colville-Nash, Derek W. Gilroy, S Asculai, Derek A. Willoughby, A. R. Moore
Publikováno v:
International Journal of Immunopharmacology. 21:195-203
Others have previously shown that superoxide dismutase conjugated with hyaluronan (HA) retains enzymic activity but is non-immunogenic. Whether HA could be widely used to prevent sensitisation to protein/polypeptide therapeutics is not known. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8670320862c4ff780ad11a9a53a96cb
https://doi.org/10.1016/s0192-0561(98)00081-2
https://doi.org/10.1016/s0192-0561(98)00081-2