Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Paul Chaplin"'
Autor:
Maria Hinterberger, Kathrin Endt, Barbara Bathke, Matthias Habjan, Alexander Heiseke, Marc Schweneker, Julia Von Rohrscheidt, Cigdem Atay, Paul Chaplin, Markus Kalla, Jürgen Hausmann, Carolin Schmittwolf, Henning Lauterbach, Ariane Volkmann, Hubertus Hochrein, José Medina-Echeverz
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract The induction of antiviral innate immunity by systemic immunization with live virus can be employed to positively impact the response to therapeutic vaccination. We previously demonstrated that systemic immunization with a non-replicating MV
Externí odkaz:
https://doaj.org/article/069aec9d569d4a3e88025d5a9a8e6ab5
Autor:
Kathrin Endt, Yvonne Wollmann, Jana Haug, Constanze Bernig, Markus Feigl, Alexander Heiseke, Markus Kalla, Hubertus Hochrein, Mark Suter, Paul Chaplin, Ariane Volkmann
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Respiratory syncytial virus (RSV) causes a respiratory disease with a potentially fatal outcome especially in infants and elderly individuals. Several vaccines failed in pivotal clinical trials, and to date, no vaccine against RSV has been licensed.
Externí odkaz:
https://doaj.org/article/ba116f6fd77346338803ea293d9d69ae
Autor:
Ariane Volkmann, Gerrit Koopman, Petra Mooij, Ernst J. Verschoor, Babs E. Verstrepen, Willy M. J. M. Bogers, Manja Idorn, Søren R. Paludan, Søren Vang, Morten A. Nielsen, Adam F. Sander, Carolin Schmittwolf, Hubertus Hochrein, Paul Chaplin
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide pandemic. Here, we present non-human primate immunogenicity and protective efficacy data generated with the capsid virus-like particle (cVLP)-based vaccine ABNCoV2 th
Externí odkaz:
https://doaj.org/article/70276a3707f448aaac6b86a678a0b8dd
Autor:
José Medina-Echeverz, Maria Hinterberger, Marco Testori, Marlene Geiger, Raphael Giessel, Barbara Bathke, Ronny Kassub, Fabienne Gräbnitz, Giovanna Fiore, Sonia T. Wennier, Paul Chaplin, Mark Suter, Hubertus Hochrein, Henning Lauterbach
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
CD40 agonists have been investigated as a strategy to awaken the immune system against cancers. Here, the authors use a virus encoding CD40L and tumour-associated antigens to enhance innate and adaptive immunity that together with tumour targeting an
Externí odkaz:
https://doaj.org/article/d593337aeba54d49978178381a7a20e5
Autor:
Pedro Berraondo, Ignacio Melero, Jose Medina-Echeverz, Maria Hinterberger, Raphael Giessel, Giovanna Fiore, Fabienne Graebnitz, Barbara Bathke, Sonia Wennier, Paul Chaplin, Mark Suter, Henning Lauterbach, Hubertus Hochrein
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)
Background Human cancers are extraordinarily heterogeneous in terms of tumor antigen expression, immune infiltration and composition. A common feature, however, is the host′s inability to mount potent immune responses that prevent tumor growth effe
Externí odkaz:
https://doaj.org/article/d0cf6008b6a24b75a3683b7822de00b1
Autor:
Edgar Turner Overton, Steven J Lawrence, Eva Wagner, Katrin Nopora, Siegfried Rösch, Philip Young, Darja Schmidt, Christian Kreusel, Sonja De Carli, Thomas P Meyer, Heinz Weidenthaler, Nathaly Samy, Paul Chaplin
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195897 (2018)
Modified Vaccinia Ankara (MVA) is a live, viral vaccine under advanced development as a non-replicating smallpox vaccine. A randomised, double-blind, placebo-controlled phase III clinical trial was conducted to demonstrate the humoral immunogenic equ
Externí odkaz:
https://doaj.org/article/6a929566399d4555bb28b7013167f596
Autor:
Stephanie L. Sanos, Ronny Kassub, Marco Testori, Marlene Geiger, Juliane Pätzold, Raphael Giessel, Johanna Knallinger, Barbara Bathke, Fabienne Gräbnitz, Kay Brinkmann, Paul Chaplin, Mark Suter, Hubertus Hochrein, Henning Lauterbach
Publikováno v:
Frontiers in Immunology, Vol 8 (2018)
Bacterial flagellin enhances innate and adaptive immune responses and is considered a promising adjuvant for the development of vaccines against infectious diseases and cancer. Antigen-presenting cells recognize flagellin with the extracellular TLR5
Externí odkaz:
https://doaj.org/article/202827b76b0b4fcf92533824f7ea76ce
Autor:
Richard N Greenberg, Christine M Hay, Jack T Stapleton, Thomas C Marbury, Eva Wagner, Eva Kreitmeir, Siegfried Röesch, Alfred von Krempelhuber, Philip Young, Richard Nichols, Thomas P Meyer, Darja Schmidt, Josef Weigl, Garth Virgin, Nathaly Arndtz-Wiedemann, Paul Chaplin
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157335 (2016)
BACKGROUND:Modified Vaccinia Ankara MVA-BN® is a live, highly attenuated, viral vaccine under advanced development as a non-replicating smallpox vaccine. In this Phase II trial, the safety and immunogenicity of Modified Vaccinia Ankara MVA-BN® (MVA
Externí odkaz:
https://doaj.org/article/fc2b41725d244487b4da1c0519dc89df
Autor:
Richard N Greenberg, Maria Yadira Hurley, Dinh V Dinh, Serena Mraz, Javier Gomez Vera, Dorothea von Bredow, Alfred von Krempelhuber, Siegfried Roesch, Garth Virgin, Nathaly Arndtz-Wiedemann, Thomas Peter Meyer, Darja Schmidt, Richard Nichols, Philip Young, Paul Chaplin
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0138348 (2015)
Replicating smallpox vaccines can cause severe complications in individuals with atopic dermatitis (AD). Prior studies evaluating Modified Vaccinia Ankara virus (MVA), a non-replicating vaccine in humans, showed a favorable safety and immunogenicity
Externí odkaz:
https://doaj.org/article/842751fd6ae54b48bb6e090f2e1f0bdb
Autor:
Richard N Greenberg, Maria Yadira Hurley, Dinh V Dinh, Serena Mraz, Javier Gomez Vera, Dorothea von Bredow, Alfred von Krempelhuber, Siegfried Roesch, Garth Virgin, Nathaly Arndtz-Wiedemann, Thomas Peter Meyer, Darja Schmidt, Richard Nichols, Philip Young, Paul Chaplin
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142802 (2015)
Externí odkaz:
https://doaj.org/article/b47273e0fd7145fc972bb2c18d9a3822