Výsledky vyhledávání - "Paul C. Watkins"

AMLI fusion transcripts in t(3;21) positive leukemia: Evidence of molecular heterogeneity and usage of splicing sites frequently involved in the generation of normalAMLI transcripts

Autor: Paul C. Watkins, Fabrizia Faustinella, Anne Hagemeijer, Nicoletta Sacchi, Paul E. Nisson, J. Wijsman

Publikováno v: Genes, Chromosomes and Cancer. 11:226-236

The t(3;21)(q26;q22) is associated with chronic myelogenous leukemia in blast crisis (CML-BC), leukemia evolving from (therapy-related) myelodysplasia, and with leukemia following other hematopoietic proliferative diseases. Molecular cytogenetic anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4724daf272ee83d571f727cb50a68a4a
https://doi.org/10.1002/gcc.2870110405

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Linkage of Dominant Hereditary Spherocytosis to the Gene for the Erythrocyte Membrane-Skeleton Protein Ankyrin

Autor: Tang K. Tang, Bernard G. Forget, Katherine M. John, Fernando Ferreira Costa, John C. Winkelmann, Samuel E. Lux, Paul C. Watkins, Peter Agre

Publikováno v: New England Journal of Medicine. 323:1046-1050

HEREDITARY spherocytosis is a heterogeneous disorder characterized by hemolytic anemia, spheroidal red cells, and increased osmotic fragility of erythrocytes. The majority of the patients have an a...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb041fdbdcc6a6dd52c88406e86c08c5
https://doi.org/10.1056/nejm199010113231507

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Generation of 19 STS markers that can be anchored at specific sites on human chromosome 21

Autor: Toshihiko Eki, Teruyo Sakakura, Hiroyuki Tashiro, Yasufumi Murakami, Xiaoren Tang, Kazushige Yokoyama, Paul C. Watkins, Ellchi Soeda

Publikováno v: Genomics. 14:185-187

Sequence-tagged sites (STSs) are short stretches of DNA that can be specifically detected by the polymerase chain reaction (PCR) and can be used to construct long-range physical maps of chromosomal DNA. These STSs can be detected by PCR assays develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688f789badddb1e9d01769b2832d8aee
https://doi.org/10.1016/s0888-7543(05)80304-0

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Isolation of Exons from Cloned DNA by Exon Trapping

Autor: Paul E. Nisson, David B. Krizman, Paul C. Watkins

Publikováno v: Current Protocols in Human Genetics

Exon trapping is an RNA polymerase chain reaction (PCR) method to clone expressed sequences or exons directly from mammalian genomic DNA. The Basic Protocol 1 basic protocol in this unit describes the method for trapping internal exons from cosmid cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80de0a38d429a751e575ea5f5d4e0f01
https://doi.org/10.1002/0471142905.hg0601s03

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Cloning of a portion of the chromosomal gene and cDNA for human beta-fodrin, the nonerythroid form of beta-spectrin

Autor: Bernard G. Forget, Jon S. Morrow, M.G. Byers, Alphonse L. Scarpa, Paul C. Watkins, Jan Gowth Chang, Alan S. Harris, Thomas B. Shows, Roger L. Eddy

Publikováno v: Genomics. 17(2)

A 96-bp synthetic oligonucleotide corresponding to an amino acid sequence near the N-terminus of erythroid [beta]-spectrin was used to screen a human genomic library, and two overlapping recombinants were isolated. DNA sequence analysis established t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::558dd173bf4aa867a519e0944450abe7
https://pubmed.ncbi.nlm.nih.gov/8406479

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The exon trapping assay partly discriminates against alternatively spliced exons

Autor: Athena Andreadis, Paul E. Nisson, Paul C. Watkins, Kenneth S. Kosik

Publikováno v: Nucleic acids research. 21(9)

A cosmid containing eight exons of the gene coding for the microtubule-associated tau protein was subjected to the exon trapping assay. All the constitutive exons contained in the cosmid (4, 5, 7 and 9) were efficiently captured regardless of size. O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4365f4f162c51ced0b206f76b73128d2
https://pubmed.ncbi.nlm.nih.gov/7684835

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Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells

Autor: Nicoletta Sacchi, Paul E. Nisson, Paul C. Watkins

Publikováno v: Cancer genetics and cytogenetics. 63(2)

In the t(8;21)(q22;q22) of acute myelogenous leukemia (AML), the breakpoint on chromosome 21 disrupts the AML1 gene, generally in the intron between exons 5 and 6. To isolate fusion transcripts of AML1, and an as yet unidentified gene on chromosome 8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adab6cf9bf41e7a48e391dfaf6988323
https://pubmed.ncbi.nlm.nih.gov/8467483

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