Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Paul C. Trippier"'
Autor:
Angelica V. Carmona, Shirisha Jonnalagadda, Alfie M. Case, Krishnaiah Maddeboina, Sravan K. Jonnalagadda, Louise F. Dow, Ling Duan, Trevor M. Penning, Paul C. Trippier
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Aldo-keto reductase 1C3 (AKR1C3) is a protein upregulated in prostate cancer, hematological malignancies, and other cancers where it contributes to proliferation and chemotherapeutic resistance. Androgen receptor splice variant 7 (ARv7) is t
Externí odkaz:
https://doaj.org/article/e4ce2a22fe6441639dc3ca4d9f796b99
Autor:
Joelle Makoukji, Fadi Saadeh, Karl Albert Mansour, Sally El‐Sitt, Jamal Al Ali, Nihar Kinarivala, Paul C. Trippier, Rose‐Mary Boustany
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 5, Iss 9, Pp 1089-1103 (2018)
Abstract Objective Neuronal Ceroid Lipofuscinoses (NCL) are fatal inherited neurodegenerative diseases with established neuronal cell death and increased ceramide levels in brain, hence, a need for disease‐modifying drug candidates, with potential
Externí odkaz:
https://doaj.org/article/e661f20a7f5146d8aa6824cfbddc37a8
Publikováno v:
Molecules, Vol 26, Iss 20, p 6235 (2021)
Batten disease or neuronal ceroid lipofuscinosis (NCL) is a group of rare, fatal, inherited neurodegenerative lysosomal storage disorders. Numerous genes (CLN1–CLN8, CLN10–CLN14) were identified in which mutations can lead to NCL; however, the un
Externí odkaz:
https://doaj.org/article/32231524a38c4af59850df516df091e0
Autor:
Katia Maalouf, Joelle Makoukji, Sara Saab, Nadine J. Makhoul, Angelica V. Carmona, Nihar Kinarivala, Noël Ghanem, Paul C. Trippier, Rose-Mary Boustany
Publikováno v:
Cells, Vol 9, Iss 8, p 1872 (2020)
CLN3 disease is a fatal neurodegenerative disorder affecting children. Hallmarks include brain atrophy, accelerated neuronal apoptosis, and ceramide elevation. Treatment regimens are supportive, highlighting the importance of novel, disease-modifying
Externí odkaz:
https://doaj.org/article/a2bef69d6b734d34b5e6c96c27a64668
Autor:
Ahmed Morsy, Krishnaiah Maddeboina, Ju Gao, Hezhen Wang, Juan Valdez, Louise F. Dow, Xinglong Wang, Paul C. Trippier
Publikováno v:
ACS Chemical Neuroscience. 13:2176-2190
Alzheimer's disease (AD) is the most common dementia affecting one in nine people over 65. Only a handful of small-molecule drugs and the anti-β amyloid (Aβ) antibody aducanumab are approved to treat AD. However, they only serve to reduce symptoms
Autor:
Yong Zhang, Sejal Sharma, Shiva H. Esfahani, Shirisha Jonnalagadda, Aarfa Queen, Saeideh Nozohouri, Dhavalkumar Patel, Paul C. Trippier, Vardan T. Karamyan, Thomas J. Abbruscato
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development.
Autor:
Maria-Jesus Blanco, Amanda Bryant-Friedrich, Gunda Georg, Amjad Ali, Paul L. Ornstein, Lori Ferrins, Paul C. Trippier
Publikováno v:
ACS Medicinal Chemistry Letters.
Autor:
Paul C. Trippier, Trevor M. Penning, Sanjay K. Srivastava, Phumvadee Wangtrakluldee, Tianzhu Zang, Nehal Gupta, Kshitij Verma
Aldo-keto reductase 1C3 (AKR1C3), also known as type 5 17 β-hydroxysteroid dehydrogenase, is responsible for intratumoral androgen biosynthesis, contributing to the development of castration-resistant prostate cancer (CRPC) and eventual chemotherape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::542f6b08bf08d3952e982df2f5645c06
https://doi.org/10.1158/1535-7163.c.6538467.v1
https://doi.org/10.1158/1535-7163.c.6538467.v1
Autor:
Paul C. Trippier, Trevor M. Penning, Sanjay K. Srivastava, Phumvadee Wangtrakluldee, Tianzhu Zang, Nehal Gupta, Kshitij Verma
Supplementary figure S6: Co-treatments of KV-37 with ENZ do not exert synergistic cytotoxic effects in LNCaP and 22Rv1 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6867cb0a6a514123cea6f3a72d4964f
https://doi.org/10.1158/1535-7163.22506675
https://doi.org/10.1158/1535-7163.22506675
Autor:
Paul C. Trippier, Trevor M. Penning, Sanjay K. Srivastava, Phumvadee Wangtrakluldee, Tianzhu Zang, Nehal Gupta, Kshitij Verma
Supplementary figure S4 & S5: S4: Baccharin does not exert cytotoxicity on prostate cancer cell lines. S5: Percentage cell viability of ENZ at indicated time points across cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35db9202f2b38d1c3f0fec77c739931a
https://doi.org/10.1158/1535-7163.22506681.v1
https://doi.org/10.1158/1535-7163.22506681.v1