Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Paul C. McDonald"'
Autor:
Hassan A. Ali, Joanna M. Karasinska, James T. Topham, Danisha Johal, Steve Kalloger, Andrew Metcalfe, Cassia S. Warren, Anthony Miyagi, Lan V. Tao, Maya Kevorkova, Shawn C. Chafe, Paul C. McDonald, Shoukat Dedhar, Seth J. Parker, Daniel J. Renouf, David F. Schaeffer
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-13 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease characterized by complex metabolic rewiring that enables growth in changing nutrient availability and oxygen conditions. Transcriptome-based prognostic PDAC tu
Externí odkaz:
https://doaj.org/article/a2c84c9d9241460d889b4c891a5bea32
Autor:
Paul C. McDonald, Shoukat Dedhar
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The tumour-associated carbonic anhydrases (CA) IX and XII are upregulated by cancer cells to combat cellular and metabolic stress imparted by hypoxia and acidosis in solid tumours. Owing to its tumour-specific expression and function, CAIX is an attr
Externí odkaz:
https://doaj.org/article/1950cb00a5734fb9a07bdd93529ee6ef
Autor:
Anne E.G. Lenferink, Paul C. McDonald, Christiane Cantin, Suzanne Grothé, Mylene Gosselin, Jason Baardsnes, Myriam Banville, Paul Lachance, Alma Robert, Yuneivy Cepero-Donates, Stevo Radinovic, Patrick Salois, Marie Parat, Hafida Oamari, Annie Dulude, Mehul Patel, Martin Lafrance, Andrea Acel, Nathalie Bousquet-Gagnon, Denis L’Abbé, Alex Pelletier, Félix Malenfant, Maria Jaramillo, Maureen O’Connor-Mccourt, Cunle Wu, Yves Durocher, Mélanie Duchesne, Christine Gadoury, Anne Marcil, Yves Fortin, Beatrice Paul-Roc, Maurizio Acchione, Shawn C. Chafe, Oksana Nemirovsky, Joseph Lau, Francois Bénard, Shoukat Dedhar
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
The architectural complexity and heterogeneity of the tumor microenvironment (TME) remains a substantial obstacle in the successful treatment of cancer. Hypoxia, caused by insufficient oxygen supply, and acidosis, resulting from the expulsion of acid
Externí odkaz:
https://doaj.org/article/a78bd5c3c72d4143937f4cd8eec87eef
Autor:
Joey G. Sheff, John F. Kelly, Anna Robotham, Traian Sulea, Félix Malenfant, Denis L’Abbé, Mélanie Duchesne, Alex Pelletier, Jean Lefebvre, Andrea Acel, Marie Parat, Mylene Gosselin, Cunle Wu, Yves Fortin, Jason Baardsnes, Henk Van Faassen, Shannon Awrey, Shawn C. Chafe, Paul C. McDonald, Shoukat Dedhar, Anne E.G. Lenferink
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Human carbonic anhydrase (hCAIX), an extracellular enzyme that catalyzes the reversible hydration of CO2, is often overexpressed in solid tumors. This enzyme is instrumental in maintaining the survival of cancer cells in a hypoxic and acidic tumor mi
Externí odkaz:
https://doaj.org/article/05ceb9ddaa0e4ba48f2d8c3227f954cc
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 4 (2016)
Hypoxia is an important contributor to the heterogeneity of the microenvironment of solid tumors and is a significant environmental stressor that drives adaptations which are essential for the survival and metastatic capabilities of tumor cells. Crit
Externí odkaz:
https://doaj.org/article/f40eb9e004ad4bdd87605b8450c6340e
Publikováno v:
Metabolites, Vol 8, Iss 1, p 20 (2018)
Hypoxia is a prominent feature of the tumor microenvironment (TME) and cancer cells must dynamically adapt their metabolism to survive in these conditions. A major consequence of metabolic rewiring by cancer cells in hypoxia is the accumulation of ac
Externí odkaz:
https://doaj.org/article/d51b8d8a86ca4841bdba0bc2ab67e396
Autor:
Shoukat Dedhar, Sohrab P. Shah, Youwen Zhou, Andrew I. Minchinton, Ali Bashashati, Jordan A. Gillespie, Jennifer H.E. Baker, Alastair H. Kyle, Alberto Delaidelli, Dongxia Gao, Samantha Burugu, Geetha Venkateswaran, Oksana Nemirovsky, Saeed Saberi, Paul C. McDonald, Shawn C. Chafe
Supplementary Figures S1-S6 and Tables S1-S4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62703df9bd4941f7372f5184567b32ca
https://doi.org/10.1158/2326-6066.22542499.v1
https://doi.org/10.1158/2326-6066.22542499.v1
Autor:
Shoukat Dedhar, Sohrab P. Shah, Youwen Zhou, Andrew I. Minchinton, Ali Bashashati, Jordan A. Gillespie, Jennifer H.E. Baker, Alastair H. Kyle, Alberto Delaidelli, Dongxia Gao, Samantha Burugu, Geetha Venkateswaran, Oksana Nemirovsky, Saeed Saberi, Paul C. McDonald, Shawn C. Chafe
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5fda4d7cba3dcb9c590702a055b53d
https://doi.org/10.1158/2326-6066.22542496.v1
https://doi.org/10.1158/2326-6066.22542496.v1
Autor:
Shoukat Dedhar, Claudiu T. Supuran, Jean-Yves Winum, Nadia Touisni, Andrea Scozzafava, Fabrizio Carta, Fabio Pacchiano, Andrew Minchinton, Christopher M. Overall, Calvin Roskelley, Marcel Bally, Dawn Waterhouse, Brent W. Sutherland, Blaise Clarke, David Huntsman, Samuel Leung, Ulrich auf dem Keller, Alastair Kyle, Ardalan Ahmadi, Christina Ostlund, Stephen Chia, Arusha Oloumi, Paul C. McDonald, Yuanmei Lou
Supplementary Figure 4 from Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df1f3b00c4049060ae420b1a6fba846
https://doi.org/10.1158/0008-5472.22389683
https://doi.org/10.1158/0008-5472.22389683
Autor:
Frank J. Rauscher, Katherine L.B. Borden, Shoukat Dedhar, Qihong Huang, Emmanuel Skordalakes, David W. Speicher, Alexandra S. Carolin, Christopher S. Paterno, Bruce Malkowicz, William Fredericks, Andrew J. Caton, Meenhard Herlyn, Torben Orntoft, Electron Kebebew, Mei He, Zhaoyuan Hou, Jayashree Karar, Paul C. McDonald, Jeremy W. Prokop, Michael J. Osborne, Mehdi Talebzadeh-Farrooji, Hongzhuang Peng
Total mRNA was extracted from cancer cell lines using RNeasy Mini Kit (Qiagen).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ade46a990104f62bb8b08043921e726
https://doi.org/10.1158/0008-5472.22401225
https://doi.org/10.1158/0008-5472.22401225