Výsledky vyhledávání - "Paul C. MacMullin"

Akademický článek

Depressed glutamate transporter 1 expression in a mouse model of Dravet syndrome

Autor: Mustafa Q. Hameed, Benjamin Hui, Rui Lin, Paul C. MacMullin, Andres Pascual‐Leone, Sheryl Anne D. Vermudez, Alexander Rotenberg

Publikováno v: Annals of Clinical and Translational Neurology, Vol 10, Iss 9, Pp 1695-1699 (2023)

Abstract Dravet syndrome (DS) is a monogenic, often refractory, epilepsy resultant from SCN1A haploinsufficiency in humans. A novel therapeutic target in DS that can be engaged in isolation or as adjunctive therapy is highly desirable. Here, we demon

Externí odkaz: https://doaj.org/article/aaabd5b003034c66832686d8f79400a3

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N-acetylcysteine treatment mitigates loss of cortical parvalbumin-positive interneuron and perineuronal net integrity resulting from persistent oxidative stress in a rat TBI model

Autor: Mustafa Q Hameed, Nathaniel Hodgson, Henry H C Lee, Andres Pascual-Leone, Paul C MacMullin, Ali Jannati, Sameer C Dhamne, Takao K Hensch, Alexander Rotenberg

Publikováno v: Cerebral Cortex. 33:4070-4084

Traumatic brain injury (TBI) increases cerebral reactive oxygen species production, which leads to continuing secondary neuronal injury after the initial insult. Cortical parvalbumin-positive interneurons (PVIs; neurons responsible for maintaining co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e119c72a5e38619a87852ec8c4d9246
https://doi.org/10.1093/cercor/bhac327

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