Výsledky vyhledávání - "Paul C. Hirom"

SF-B that binds to a negative element in glutathione transferase P gene is similar or identical to trans-activator

Autor: Mitchell B. Diccianni, T Suzuki, Paul C. Hirom, Masayoshi Imagawa, Masami Muramatsu, Yumi Koyama, Shigeru Morimura, Shigehiro Osada

Publikováno v: Biochemical and Biophysical Research Communications. 179:293-300

We have previously identified a silencer (negative enhancer) in glutathione transferase P (GST-P) gene which is strongly and specifically induced during hepatocarcinogenesis of the rat. At least three trans-acting factors bind to multiple cis-element

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0c94a3179ddfd670655927501d2e2ec
https://doi.org/10.1016/0006-291x(91)91368-m

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Metabolic activation to a mutagen of 3-hydroxy-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene, a secondary metabolite of benzo[a]pyrene

Autor: Franz Oesch, Paul C. Hirom, Charles A. Kirkby, Hansruedi Glatt, Odartey Ribeiro, Albrecht Seidel

Publikováno v: Carcinogenesis. 8:1621-1627

3-Hydroxy-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene (3-OH-BP-7,8-diol) was isolated from arylsulfatase/beta-glucuronidase-treated bile of rats to which 3-hydroxybenzo[a]pyrene (3-OH-BP) has been administered. This triol was investigated for mutag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0128de3a24dc0f474eca3f1efe9212
https://doi.org/10.1093/carcin/8.11.1621

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Biliary excretion, systemic availability and reactivity of metabolites following intraportal infusion of [3H]benzo[a]pyrene in the rat

Autor: Peter Millburn, G.S. Frost, J.K. Chipman, Paul C. Hirom

Publikováno v: Carcinogenesis. 2:741-745

Following the intraportal infusion of [3H]benzo[a]pyrene (BP) at two dose levels (5 and 0.125 mumol/kg) in the rat, metabolites were excreted via the bile and were released into the hepatic venous blood. At each dose level, a significant portion (app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a841bd1aa7ffeea6f84066653980fc
https://doi.org/10.1093/carcin/2.8.741

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Secondary metabolites of benzo[a]pyrene: 3-hydroxy-trans-7,8-dihydro-7,8-dihydroxybenzo[a]pyrene, a biliary metabolite of 3-hydroxybenzo[a]pyrene in the rat

Autor: Odartey Ribeiro, Peter Millburn, Charles A. Kirkby, Paul C. Hirom

Publikováno v: Carcinogenesis. 6(10)

Rats administered 3-hydroxybenzo[a]pyrene (50 mg/kg, i.p.), excrete via the bile metabolites which, after treatment with beta-glucuronidase and aryl sulphatase, yield, in addition to 3-hydroxybenzo[a]pyrene, 3-hydroxy-trans-7,8-dihydro-7,8-dihydroxyb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d734e7208fdc6cba49e1298450529b
https://pubmed.ncbi.nlm.nih.gov/3876175

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Reactive intermediates from 3-hydroxybenzo[a]pyrene and its glucuronide

Autor: Charles A. Kirkby, Peter Millburn, Odartey Ribeiro, Paul C. Hirom

Publikováno v: Carcinogenesis. 7(3)

3-Hydroxybenzo[a]pyrene (3-OH-BaP) is oxidized by the horseradish peroxidase/H2O2 system to benzo[a]pyrene-3,6-quinone. In the presence of N-acetylcysteine one other product is also formed. This was identified by its chemical, and u.v., mass and n.m.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb423a0e991d843dedcc433aab01bdcd
https://pubmed.ncbi.nlm.nih.gov/3948331

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