Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Paul C. Donaghy"'
Autor:
Kathryn A. Wyman-Chick, Parichita Chaudhury, Ece Bayram, Carla Abdelnour, Elie Matar, Shannon Y. Chiu, Daniel Ferreira, Calum A. Hamilton, Paul C. Donaghy, Federico Rodriguez-Porcel, Jon B. Toledo, Annegret Habich, Matthew J. Barrett, Bhavana Patel, Alberto Jaramillo-Jimenez, Gregory D. Scott, Joseph P. M. Kane
Publikováno v:
Neurology and Therapy, Vol 13, Iss 3, Pp 885-906 (2024)
Abstract This pragmatic review synthesises the current understanding of prodromal dementia with Lewy bodies (pDLB) and prodromal Alzheimer’s disease (pAD), including clinical presentations, neuropsychological profiles, neuropsychiatric symptoms, bi
Externí odkaz:
https://doaj.org/article/eeb3302b9954467faf0ca0b4ceb4c0be
Autor:
Xiaobei Pan, Paul C. Donaghy, Gemma Roberts, Leonidas Chouliaras, John T. O’Brien, Alan J. Thomas, Amanda J. Heslegrave, Henrik Zetterberg, Bernadette McGuinness, Anthony P. Passmore, Brian D. Green, Joseph P. M. Kane
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2024)
BackgroundIn multifactorial diseases, alterations in the concentration of metabolites can identify novel pathological mechanisms at the intersection between genetic and environmental influences. This study aimed to profile the plasma metabolome of pa
Externí odkaz:
https://doaj.org/article/8aad56e5df91470bbb204ca5a316b750
Autor:
Jay Amin, Daniel Erskine, Paul C. Donaghy, Ajenthan Surendranathan, Peter Swann, Amy P. Kunicki, Delphine Boche, Clive Holmes, Ian G. McKeith, John T. O'Brien, Jessica L. Teeling, Alan J. Thomas
Publikováno v:
Neurobiology of Disease, Vol 168, Iss , Pp 105698- (2022)
Dementia with Lewy bodies (DLB) is the second most common neurodegenerative cause of dementia, behind Alzheimer's disease (AD). The profile of inflammation in AD has been extensively researched in recent years, with evidence that chronic peripheral i
Externí odkaz:
https://doaj.org/article/1dfe16a3a9ee479096b69460084cc8ab
Autor:
Julia Schumacher, John-Paul Taylor, Calum A. Hamilton, Michael Firbank, Ruth A. Cromarty, Paul C. Donaghy, Gemma Roberts, Louise Allan, Jim Lloyd, Rory Durcan, Nicola Barnett, John T. O’Brien, Alan J. Thomas
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-12 (2020)
Abstract Objectives To investigate using quantitative EEG the (1) differences between patients with mild cognitive impairment with Lewy bodies (MCI-LB) and MCI with Alzheimer’s disease (MCI-AD) and (2) its utility as a potential biomarker for early
Externí odkaz:
https://doaj.org/article/fa6cc008671546c1a51019953d061710
Autor:
Julia Schumacher, Alan J. Thomas, Luis R. Peraza, Michael Firbank, Ruth Cromarty, Calum A. Hamilton, Paul C. Donaghy, John T. O’Brien, John-Paul Taylor
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-12 (2020)
Abstract Background Lewy body dementia (LBD), which includes dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD), is characterised by marked deficits within the cholinergic system which are more severe than in Alzheimer’s disea
Externí odkaz:
https://doaj.org/article/dc299c6c0cc84420ae5fc6f9b428c5e0
Autor:
Julia Schumacher, John-Paul Taylor, Calum A. Hamilton, Michael Firbank, Ruth A. Cromarty, Paul C. Donaghy, Gemma Roberts, Louise Allan, Jim Lloyd, Rory Durcan, Nicola Barnett, John T. O'Brien, Alan J. Thomas
Publikováno v:
NeuroImage: Clinical, Vol 30, Iss , Pp 102604- (2021)
Objectives: To investigate in vivo degeneration of the cholinergic system in mild cognitive impairment with Lewy bodies (MCI-LB), we studied nucleus basalis of Meynert (NBM) volumes from structural MR images and its relation to EEG slowing and cognit
Externí odkaz:
https://doaj.org/article/389e76eaff8945d7ad5edf30f2c4205b
Autor:
Jim J. Lloyd, George Petrides, Paul C. Donaghy, Sean J. Colloby, Johannes Attems, John T. O'Brien, Gemma Roberts, Alan J. Thomas
Publikováno v:
NeuroImage: Clinical, Vol 20, Iss , Pp 823-829 (2018)
Background: Dopaminergic loss on 123I-Ioflupane brain imaging is a recognised biomarker for dementia with Lewy bodies. It is usually assessed using a visual rating scale developed for Parkinson's disease, which may not be optimal for dementia with Le
Externí odkaz:
https://doaj.org/article/d1e4b8c74a364739a3ca77b6c7f4d879
Autor:
Paul C. Donaghy, Michael Firbank, George Petrides, Jim Lloyd, Nicola Barnett, Kirsty Olsen, Amanda Heslegrave, Henrik Zetterberg, Alan J. Thomas, John T. O'Brien
Publikováno v:
Parkinsonism & Related Disorders. 101:111-116
INTRODUCTION: Amyloid-β (Aβ) deposition is common in dementia with Lewy bodies (DLB) and has been associated with more rapid disease progression. An effective biomarker that identified the presence of significant brain Aβ in people with DLB may be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb9cb883e9f19aa988ceb8e0aa9a91c
https://doi.org/10.1016/j.parkreldis.2022.07.008
https://doi.org/10.1016/j.parkreldis.2022.07.008
Autor:
Gemma Roberts, Rory Durcan, George Petrides, Sean J. Colloby, Alan J. Thomas, Michael J. Firbank, John-Paul Taylor, John T. O'Brien, Sarah Lawley, Calum A Hamilton, Louise Allan, Joanna Ciafone, Paul C. Donaghy, Peter Gallagher
Publikováno v:
Journal of the International Neuropsychological Society. 28:963-973
Objective:The present study aimed to clarify the neuropsychological profile of the emergent diagnostic category of Mild Cognitive Impairment with Lewy bodies (MCI-LB) and determine whether domain-specific impairments such as in memory were related to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4914b770312ecb97e86c8526e6b9038
https://doi.org/10.1017/s1355617721001181
https://doi.org/10.1017/s1355617721001181
Autor:
Mark J. Rapoport, Justin Nathaniel Chee, Thadshagini Prabha, Jamie Dow, Ian Gillespie, Sjaan Koppel, Judith L. Charlton, Desmond O’Neill, Paul C. Donaghy, Angela Onkay Ho, John-Paul Taylor, Mark Tant
Publikováno v:
Canadian journal of psychiatry. Revue canadienne de psychiatrie.
Objective Psychiatric disorders and their treatments have the potential to adversely impact driving skills. However, it is unclear to what extent this poses a public health risk by increasing the risk of motor vehicle crashes (MVCs). The aim of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::399dd9277456075aebd676b7373f6e15
https://pubmed.ncbi.nlm.nih.gov/36198019
https://pubmed.ncbi.nlm.nih.gov/36198019