Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Paul C. Blainey"'
Autor:
Sri Gowtham Thakku, Jackson Lirette, Kanagavel Murugesan, Julie Chen, Grant Theron, Niaz Banaei, Paul C. Blainey, James Gomez, Sharon Y. Wong, Deborah T. Hung
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
In this work, the authors developed a multiplexed, minimally invasive, CRISPR-Cas13-based approach to detect Mycobacterium tuberculosis cell-free DNA in the plasma of active pulmonary tuberculosis patients.
Externí odkaz:
https://doaj.org/article/bbeaeafe49934ce4acd3e1fecb9b7f87
Autor:
Megan Shand, Jose Soto, Lee Lichtenstein, David Benjamin, Yossi Farjoun, Yehuda Brody, Yosef Maruvka, Paul C. Blainey, Eric Banks
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-8 (2020)
Megan Shand et al. present Lineage derived Somatic Truth (LinST), a validated data set of somatic mutations from a colon cancer cell line with a known lineage tree structure. They show that LinST can be used to benchmark true-positive and false-posit
Externí odkaz:
https://doaj.org/article/ac5e932b4eb24213a2667a14bb688207
Autor:
Syuan-Ming Guo, Remi Veneziano, Simon Gordonov, Li Li, Eric Danielson, Karen Perez de Arce, Demian Park, Anthony B. Kulesa, Eike-Christian Wamhoff, Paul C. Blainey, Edward S. Boyden, Jeffrey R. Cottrell, Mark Bathe
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Multiplexed imaging of synaptic proteins can provide useful information on the heterogeneity of synaptic architecture and plasticity. Here the authors use high affinity locked nucleic acid probes and low affinity DNA imaging probes to achieve multipl
Externí odkaz:
https://doaj.org/article/789abbb5bbe64affabf5dc217e63e1f9
Autor:
Alexandra B. Ysasi, Robert D. Bennett, Willi Wagner, Cristian D. Valenzuela, Andrew B. Servais, Akira Tsuda, Saumyadipta Pyne, Shuqiang Li, Jonna Grimsby, Prapti Pokharel, Kenneth J. Livak, Maximilian Ackermann, Paul C. Blainey, Steven J. Mentzer
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
Lung regeneration occurs in a variety of adult mammals after surgical removal of one lung (pneumonectomy). Previous studies of murine post-pneumonectomy lung growth have identified regenerative “hotspots” in subpleural alveolar ducts; however, th
Externí odkaz:
https://doaj.org/article/1d3219b82a0046cf97d080489744ae17
Autor:
Soohong Kim, Joachim De Jonghe, Anthony B. Kulesa, David Feldman, Tommi Vatanen, Roby P. Bhattacharyya, Brittany Berdy, James Gomez, Jill Nolan, Slava Epstein, Paul C. Blainey
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Shotgun DNA sequencing experiments for microbial genomic analysis are often impractical due to minimum sample input requirements. Here the authors develop a microfluidic sample preparation platform that reduces sample input requirements 100-fold and
Externí odkaz:
https://doaj.org/article/6d75a655946e42d5bd25262a8dafd41e
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Extremely compact environments can inhibit protein interactions by preventing 3-dimensional diffusion. Here the authors show that an 11-amino acid long peptide can function as a ‘molecular sled’, able to transport cargo linearly along DNA to enab
Externí odkaz:
https://doaj.org/article/17ca686a1607463e8cf9d6dac2de694a
Autor:
Robert J. Kimmerling, Gregory Lee Szeto, Jennifer W. Li, Alex S. Genshaft, Samuel W. Kazer, Kristofor R. Payer, Jacob de Riba Borrajo, Paul C. Blainey, Darrell J. Irvine, Alex K. Shalek, Scott R. Manalis
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
Existing single-cell RNA-seq methods provide the transcriptome of a cellular phenotype at a single time point. Here, Kimmerlinget al. present a microfluidic platform that enables off-chip single-cell RNA-seq after multigenerational lineage tracking u
Externí odkaz:
https://doaj.org/article/bea614acf94645cdb3402d06fdfa86be
Autor:
Kathleen A. Quan, Mohamad R. A. Sater, Cherry Uy, Robin Clifton-Koeppel, Linda L. Dickey, William Wilson, Pat Patton, Wayne Chang, Pamela Samuelson, Georgia K. Lagoudas, Teri Allen, Lenny Merchant, Rick Gannotta, Cassiana E. Bittencourt, J. C. Soto, Kaye D. Evans, Paul C. Blainey, John Murray, Dawn Shelton, Helen S. Lee, Matthew Zahn, Julia Wolfe, Keith Madey, Jennifer Yim, Shruti K. Gohil, Yonatan H. Grad, Susan S. Huang
Publikováno v:
Infection Control & Hospital Epidemiology. 44:589-596
Objective:To describe the genomic analysis and epidemiologic response related to a slow and prolonged methicillin-resistant Staphylococcus aureus (MRSA) outbreak.Design:Prospective observational study.Setting:Neonatal intensive care unit (NICU).Metho
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The infection of mammalian cells by viruses and innate immune responses to infection are spatiotemporally organized processes. Cytosolic RNA sensors trigger nuclear translocation of the transcription factor interferon regulatory factor 3 (IRF3) and c
Publikováno v:
Science Advances. 9
Cells sense a wide variety of signals and respond by adopting complex transcriptional states. Most single-cell profiling is carried out today at cellular baseline, blind to cells’ potential spectrum of functional responses. Exploring the space of c