Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Paul C. Armstrong"'
Autor:
Ami Vadgama, James Boot, Nicola Dark, Harriet E. Allan, Charles A. Mein, Paul C. Armstrong, Timothy D. Warner
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 8, Iss 5, Pp 102523- (2024)
Background: Platelet function is driven by the expression of specialized surface markers. The concept of distinct circulating subpopulations of platelets has emerged in recent years, but their exact nature remains debatable. Objectives: To design a s
Externí odkaz:
https://doaj.org/article/8ec091d9bcdb4e8381e3ad21edd45326
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
Research into the natural aging process of platelets has garnered much research interest in recent years, and there have long been associations drawn between the proportion of newly formed platelets in the circulation and the risk of thrombosis. Howe
Externí odkaz:
https://doaj.org/article/a07bef35f153430baceb089435b11e4e
Publikováno v:
Platelets, Vol 29, Iss 7, Pp 650-655 (2018)
While there are many bench and bedside tests to assess platelet reactivity, ex vivo light transmission aggregometry (LTA) remains the gold standard. LTA, however, is expensive, time-consuming and requires dedicated equipment and staff, making it impr
Externí odkaz:
https://doaj.org/article/e6b552c6264f4ba4aedf70f1a543d310
Autor:
Hannah Hsu, Melissa V. Chan, Paul C. Armstrong, Marilena Crescente, Dea Donikian, Mayuko Kondo, Timothy Brighton, Vivien Chen, Qiang Chen, David Connor, Joanne Joseph, Marie-Christine Morel-Kopp, William S. Stevenson, Christopher Ward, Timothy D. Warner, David J. Rabbolini
Publikováno v:
Pathology. 54:746-754
Identification of disordered platelet function is important to guide peri-operative bleeding management as well as long term treatment and prognostic strategies in individuals with platelet bleeding disorders. Light transmission aggregometry (LTA), t
Autor:
Laura Menke, Timothy D. Warner, Manuel Mayr, Melissa V. Chan, Marilena Crescente, Tania Maffucci, Melissa A. Hayman, Harriet E. Allan, Abhishek Joshi, Matthew L. Edin, Paul C Armstrong, Darryl C. Zeldin, Simone Marcone
Publikováno v:
J Thromb Haemost
Background Platelets circulate in the blood of healthy individuals for approximately 7-10 days regulated by finely balanced processes of production and destruction. As platelets are anucleate we reasoned that their protein composition would change as
Publikováno v:
Thrombosis Research.
Platelet ageing is an area of research which has gained much interest in recent years. Newly formed platelets, often referred to as reticulated platelets, young platelets or immature platelets, are defined as RNA-enriched and have long been thought t
Autor:
Nicholas S. Kirkby, Ivana Vojnovic, Chih-Chin Shih, Paul C Armstrong, Timothy D. Warner, Jane A. Mitchell, Melissa V. Chan
Publikováno v:
British Journal of Pharmacology. 178:4758-4771
Background and purpose P2Y12 receptor antagonists reduce platelet aggregation and the incidence of arterial thrombosis. Adenosine signalling in platelets directly affects cyclic nucleotide tone, which we have shown to have a synergistic relationship
Autor:
Clemens Gutmann, Temo Barwari, Christian Schulte, Bhawana Singh, Konstantinos Theofilatos, Abhishek Joshi, Anna Zampetaki, Melissa V Chan, Paul C Armstrong, Stefan Kiechl, Johann Willeit, Timothy D Warner, Manuel Mayr
Publikováno v:
Cardiovascular Research. 118
Background Antiplatelet therapy (APT) has improved cardiovascular outcomes, but some patients develop thrombosis despite APT. Adjusting APT to platelet reactivity with conventional platelet reactivity tests has proven unsuccessful. Many circulating n
Autor:
Paul C. Armstrong, Harriet E. Allan, Nicholas S. Kirkby, Clemens Gutmann, Abhishek Joshi, Marilena Crescente, Jane A. Mitchell, Manuel Mayr, Timothy D. Warner
Publikováno v:
Blood advances. 6(23)
The proportion of young platelets, also known as newly formed or reticulated, within the overall platelet population has been clinically correlated with adverse cardiovascular outcomes. However, our understanding of this is incomplete because of limi
Autor:
Jane A. Mitchell, Maria Vinokurova, Maria Elisa Lopes-Pires, Fisnik Shala, Paul C. Armstrong, Blerina Ahmetaj-Shala, Youssef Elghazouli, Bin Liu, Yingbi Zhou, Chuan-ming Hao, Harvey R. Herschman, Nicholas S. Kirkby
Prostacyclin is one of the bodies fundamental signalling pathways. It has long been considered principally anti-thrombotic hormone derived from the vascular endothelium. The role of non-vascular sources in prostacyclin synthesis has not been systemat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddb6179cc0bf5e2e0fe4df7ebe73f8f2
https://doi.org/10.1101/2022.01.11.475814
https://doi.org/10.1101/2022.01.11.475814