Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Paul C Driscoll"'
Autor:
Jamie A Macpherson, Alina Theisen, Laura Masino, Louise Fets, Paul C Driscoll, Vesela Encheva, Ambrosius P Snijders, Stephen R Martin, Jens Kleinjung, Perdita E Barran, Franca Fraternali, Dimitrios Anastasiou
Publikováno v:
eLife, Vol 8 (2019)
Several enzymes can simultaneously interact with multiple intracellular metabolites, however, how the allosteric effects of distinct ligands are integrated to coordinately control enzymatic activity remains poorly understood. We addressed this questi
Externí odkaz:
https://doaj.org/article/e58bac1bbbec4b70ba28e24697d45179
Autor:
Kathrin S Grassme, Acely Garza-Garcia, Jean-Paul Delgado, James W Godwin, Anoop Kumar, Phillip B Gates, Paul C Driscoll, Jeremy P Brockes
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0154176 (2016)
Anterior gradient (AG) proteins have a thioredoxin fold and are targeted to the secretory pathway where they may act in the ER, as well as after secretion into the extracellular space. A newt member of the family (nAG) was previously identified as in
Externí odkaz:
https://doaj.org/article/77becb1e71eb488abd4def8377a9719c
Autor:
Leonard L. de Boer, Lesley Vanes, Serena Melgrati, Joshua Biggs O’May, Darryl Hayward, Paul C. Driscoll, Jason Day, Alexander Griffiths, Renata Magueta, Alexander Morrell, James I. MacRae, Robert Köchl, Victor L. J. Tybulewicz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Migration of T cells is essential for their ability to mount immune responses. Chemokine-induced T cell migration requires WNK1, a kinase that regulates ion influx into the cell. However, it is not known why ion entry is necessary for T cell
Externí odkaz:
https://doaj.org/article/756fb5c46001461296daa26e0aeb116f
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70095 (2013)
Death-associated protein kinase (DAPk) is a calcium/calmodulin-regulated Ser/Thr-protein kinase that functions at an important point of integration for cell death signaling pathways. DAPk has a structurally unique multi-domain architecture, including
Externí odkaz:
https://doaj.org/article/38b80d26dead40e8bb2ea66eb3152924
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7123 (2009)
BACKGROUND:Following the amputation of a limb, newts and salamanders have the capability to regenerate the lost tissues via a complex process that takes place at the site of injury. Initially these cells undergo dedifferentiation to a state competent
Externí odkaz:
https://doaj.org/article/475515457f2148ed8b2620fba19d6387
Autor:
Xin Chen, Mariia Yuneva, Diego F. Calvisi, Darjus F. Tschaharganeh, Paul C. Driscoll, Chencheng Xie, Jingxiao Wang, Jiaoyuan Jia, Xinhua Song, Li Che, Junjie Hu, Xiaolei Li, Andrés Méndez-Lucas
Study design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317b7383a802f2523707d5ec8d8b3611
https://doi.org/10.1158/0008-5472.22415313
https://doi.org/10.1158/0008-5472.22415313
Autor:
Xin Chen, Mariia Yuneva, Diego F. Calvisi, Darjus F. Tschaharganeh, Paul C. Driscoll, Chencheng Xie, Jingxiao Wang, Jiaoyuan Jia, Xinhua Song, Li Che, Junjie Hu, Xiaolei Li, Andrés Méndez-Lucas
Different pyruvate kinase isoforms are expressed in a tissue-specific manner, with pyruvate kinase M2 (PKM2) suggested to be the predominant isoform in proliferating cells and cancer cells. Because of differential regulation of enzymatic activities,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9198d7e88607e230e28a2a8c310e396
https://doi.org/10.1158/0008-5472.c.6509223.v1
https://doi.org/10.1158/0008-5472.c.6509223.v1
Autor:
Marc Hennequart, Steven E. Pilley, Christiaan F. Labuschagne, Jack Coomes, Loic Mervant, Paul C. Driscoll, Nathalie M. Legrave, Younghwan Lee, Peter Kreuzaler, Benedict Macintyre, Yulia Panina, Julianna Blagih, David Stevenson, Douglas Strathdee, Deborah Schneider-Luftman, Eva Grönroos, Eric C. Cheung, Mariia Yuneva, Charles Swanton, Karen H. Vousden
Publikováno v:
Cell Reports. 42:112562
Mitochondrial 10-formyltetrahydrofolate (10-formyl-THF) is utilized by three mitochondrial enzymes to produce formate for nucleotide synthesis, NADPH for antioxidant defense, and formyl-methionine (fMet) to initiate mitochondrial mRNA translation. On
Autor:
Guillaume Rey, Pawan K. Jha, Radoslaw Lach, Paul C. Driscoll, Sandipan Ray, Aalim M. Weljie, Akhilesh B. Reddy, Utham K. Valekunja, James I. MacRae, Mariana Silva dos Santos, Dania Malik, Ratnasekhar Ch
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Circadian clocks coordinate mammalian behavior and physiology enabling organisms to anticipate 24-hour cycles. Transcription-translation feedback loops are thought to drive these clocks in most of mammalian cells. However, red blood cells (RBCs), whi
Publikováno v:
Journal of Proteome Research
The measurement of absolute metabolite concentrations in small samples remains a significant analytical challenge. This is particularly the case when the sample volume is only a few microliters or less and cannot be determined accurately via direct m