Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Paul C Billings"'
Autor:
Paul C Billings, Candice Bizzaro, Evan Yang, Juliet Chung, Christina Mundy, Maurizio Pacifici
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0229254 (2020)
Activins are members of the transforming growth factor-β (TGF-β) superfamily of signaling proteins and were originally identified as components of follicular fluid. The proteins are now known to play critical roles in numerous normal and pathologic
Externí odkaz:
https://doaj.org/article/390dbcd7f8df404a8a614f76e9e40062
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222784 (2019)
Activins regulate numerous processes including inflammation and are synthesized as precursors consisting of a long N-terminal pro-region and a mature protein. Genomic human databases currently list three activin A (Act A) variants termed X1, X2 and X
Externí odkaz:
https://doaj.org/article/af63010b25224d9cbaef8c031857e925
Autor:
Sayantani Sinha, Christina Mundy, Till Bechtold, Federica Sgariglia, Mazen M Ibrahim, Paul C Billings, Kristen Carroll, Eiki Koyama, Kevin B Jones, Maurizio Pacifici
Publikováno v:
PLoS Genetics, Vol 13, Iss 4, p e1006742 (2017)
Hereditary Multiple Exostoses (HME) is a rare pediatric disorder caused by loss-of-function mutations in the genes encoding the heparan sulfate (HS)-synthesizing enzymes EXT1 or EXT2. HME is characterized by formation of cartilaginous outgrowths-call
Externí odkaz:
https://doaj.org/article/159fca4cf78b4771b52c75012998f62f
Publikováno v:
Journal of Biological Chemistry. 293:14371-14383
Signaling proteins, including bone morphogenetic proteins (BMPs), specifically interact with heparan sulfate (HS). These interactions regulate protein distribution and function and are largely mediated by domains rich in basic amino acids. The N-term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88cd0048dfa71f5f7a87ae5bd66113c
https://doi.org/10.1074/jbc.ra118.003191
https://doi.org/10.1074/jbc.ra118.003191
Publikováno v:
Journal of Biological Chemistry. 293:7703-7716
Hereditary multiple exostoses (HME) is a pediatric disorder caused by heparan sulfate (HS) deficiency and is characterized by growth plate–associated osteochondromas. Previously, we found that osteochondroma formation in mouse models is preceded by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e3971aafee6ddbb7d7e106098305b1
https://doi.org/10.1074/jbc.ra117.000264
https://doi.org/10.1074/jbc.ra117.000264
Autor:
Eiki Koyama, Cheri Saunders, Hyun-Duck Nah, Till Edward Bechtold, Naito Kurio, Paul C. Billings
Publikováno v:
International Journal of Molecular Sciences
The temporomandibular joint (TMJ) is an intricate structure composed of the mandibular condyle, articular disc, and glenoid fossa in the temporal bone. Apical condylar cartilage is classified as a secondary cartilage, is fibrocartilaginous in nature,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b6c002ef6e92b94721cbe9f20b4700
https://pubmed.ncbi.nlm.nih.gov/31847127
https://pubmed.ncbi.nlm.nih.gov/31847127
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222784 (2019)
PLoS ONE
PLoS ONE
Activins regulate numerous processes including inflammation and are synthesized as precursors consisting of a long N-terminal pro-region and a mature protein. Genomic human databases currently list three activin A (Act A) variants termed X1, X2 and X
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64181125736f3e2572a044d90aef7485
https://doaj.org/article/af63010b25224d9cbaef8c031857e925
https://doaj.org/article/af63010b25224d9cbaef8c031857e925
Autor:
Raheleh Salari, Laura J. Esserman, Denise M. Wolf, Minetta C. Liu, I-Spy Trial Investigators, Svetlana Shchegrova, Derrick Renner, Angela DeMichele, Douglas Yee, Paul C. Billings, Christina Yau, Gillian L. Hirst, Bernhard Zimmermann, Laura van 't Veer, Alexey Aleshin, Hsin-Ta Wu, Lamorna Brown Swigart, Ekaterina V. Kalashnikova, Himanshu Sethi, Rita Nanda, Mark Jesus M. Magbanua, Antony Tin, Angel Rodriguez, Amy L. Delson
Publikováno v:
Cancer Research. 81:PD9-02
Background: In the I-SPY 2 TRIAL, the addition of P to standard NAC resulted in more than doubling of the pathologic complete response (pCR) rates for both hormone receptor-positive (HR+)/HER2- and triple-negative (TN) early breast cancer (EBC) patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aaa9b208cccf89e873882883cbde7c4
https://doi.org/10.1158/1538-7445.sabcs20-pd9-02
https://doi.org/10.1158/1538-7445.sabcs20-pd9-02
Autor:
Naiga Cottingham, Imad Salhab, Paul C. Billings, Rebekah S. Decker, Hyo Bin Um, Naito Kurio, Maurizio Pacifici, Cheri Saunders, Hyun-Duck Nah, Eiki Koyama, Till Edward Bechtold
Publikováno v:
Matrix Biology. :339-354
The temporomandibular joint (TMJ) is a diarthrodial joint that relies on lubricants for frictionless movement and long-term function. It remains unclear what temporal and causal relationships may exist between compromised lubrication and onset and pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0ac3bc477ce4cfbc6afbe4c3946fc8
https://doi.org/10.1016/j.matbio.2016.03.001
https://doi.org/10.1016/j.matbio.2016.03.001
Autor:
Imad Salhab, Eiki Koyama, Paul C. Billings, H. Um, Christina Mundy, Till Edward Bechtold, Cheri Saunders, Rebekah S. Decker, Naito Kurio, Hyun-Duck Nah, Maurizio Pacifici
Publikováno v:
Journal of Dental Research. 95:292-301
Heterotopic cartilage develops in certain pathologic conditions, including those affecting the human temporomandibular joint (TMJ), but the underlying molecular mechanisms remain obscure. This is in part due to the fact that a reliable animal model o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5423cb257dac7f4ad473d432f93f2f
https://doi.org/10.1177/0022034515613508
https://doi.org/10.1177/0022034515613508