Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Paul C, Norris"'
Autor:
Oliver Werz, Jana Gerstmeier, Stephania Libreros, Xavier De la Rosa, Markus Werner, Paul C. Norris, Nan Chiang, Charles N. Serhan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/b3d159e06f4847f1b24760698cd429a2
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 2 (2023)
Externí odkaz:
https://doaj.org/article/c7f7d8138b4e44f2a9a9697a41e285ce
Autor:
Bochra Tourki, Vasundhara Kain, Amanda B. Pullen, Paul C. Norris, Nirav Patel, Pankaj Arora, Xavier Leroy, Charles N. Serhan, Ganesh V. Halade
Publikováno v:
Molecular Metabolism, Vol 31, Iss , Pp 138-149 (2020)
Objective: Recently, we observed that the specialized proresolving mediator (SPM) entity resolvin D1 activates lipoxin A4/formyl peptide receptor 2 (ALX/FPR2), which facilitates cardiac healing and persistent inflammation is a hallmark of impaired ca
Externí odkaz:
https://doaj.org/article/db743dad70734920abb663bad30b0a4d
Autor:
Gijs Kooij, Claudio Derada Troletti, Alessandro Leuti, Paul C. Norris, Ian Riley, Maria Albanese, Serena Ruggieri, Stephania Libreros, Susanne M.A. van der Pol, Bert van het Hof, Yoëlle Schell, Gisella Guerrera, Fabio Buttari, Nicola Biagio Mercuri, Diego Centonze, Claudio Gasperini, Luca Battistini, Helga E. de Vries, Charles N. Serhan#, Valerio Chiurchiù#
Publikováno v:
Haematologica, Vol 105, Iss 8 (2020)
Chronic inflammation is a key pathological hallmark of multiple sclerosis (MS) and suggests that resolution of inflammation, orchestrated by specialized pro-resolving lipid mediators (LM), is impaired. Here, through targeted-metabololipidomics in per
Externí odkaz:
https://doaj.org/article/c0a9535b8ffa4ec889d4b21ad22666ee
Autor:
Oliver Werz, Jana Gerstmeier, Stephania Libreros, Xavier De la Rosa, Markus Werner, Paul C. Norris, Nan Chiang, Charles N. Serhan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Abstract Proinflammatory eicosanoids (prostaglandins and leukotrienes) and specialized pro-resolving mediators (SPM) are temporally regulated during infections. Here we show that human macrophage phenotypes biosynthesize unique lipid mediator signatu
Externí odkaz:
https://doaj.org/article/bf8ddff4771343aba2fa655e1c5cf782
Autor:
Harvey R. Herschman, Susan M. Fischer, Edward A. Dennis, Art Catapang, Carol Mikulec, Clara E. Magyar, Paul C. Norris, Darren S. Dumlao, Tomo-O Ishikawa, Jing Jiao
Pharmacologic and global gene deletion studies demonstrate that cyclooxygenase-2 (PTGS2/COX-2) plays a critical role in DMBA/TPA–induced skin tumor induction. Although many cell types in the tumor microenvironment express COX-2, the cell types in w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd2435fc347bc4275f74c20431768e88
https://doi.org/10.1158/1541-7786.c.6539956.v1
https://doi.org/10.1158/1541-7786.c.6539956.v1
Autor:
Harvey R. Herschman, Susan M. Fischer, Edward A. Dennis, Art Catapang, Carol Mikulec, Clara E. Magyar, Paul C. Norris, Darren S. Dumlao, Tomo-O Ishikawa, Jing Jiao
Skin F4/80+ macrophage from Cox-2deltaM (Cox-2flox/flox;LysMCre+) mice undergo effective targeted Cox-2 gene deletion. Macrophages were isolated from the skin of 7-9 week old Cox-2deltaM and Cox-2fl/fl mice that were treated one time with TPA to indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011606cc5cbb303e9bd1f3c01202692e
https://doi.org/10.1158/1541-7786.22511506
https://doi.org/10.1158/1541-7786.22511506
Publikováno v:
Journal of Clinical Investigation. 133
Resolution of acute inflammation is an active process orchestrated by endogenous mediators and mechanisms pivotal in host defense and homeostasis. The macrophage mediator in resolving inflammation, maresin 1 (MaR1), is a potent immunoresolvent, stimu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b89354f6370bd390e29722bffbc4fc2
https://doi.org/10.1172/jci168084
https://doi.org/10.1172/jci168084
Autor:
Vasundhara Kain, Bochra Tourki, Xavier Leroy, Pankaj Arora, Paul C. Norris, Amanda B. Pullen, Ganesh V. Halade, Charles N. Serhan, Nirav Patel
Publikováno v:
Molecular Metabolism, Vol 31, Iss, Pp 138-149 (2020)
Molecular Metabolism
Molecular Metabolism
Objective Recently, we observed that the specialized proresolving mediator (SPM) entity resolvin D1 activates lipoxin A4/formyl peptide receptor 2 (ALX/FPR2), which facilitates cardiac healing and persistent inflammation is a hallmark of impaired car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375b7a6a06dbb0f705db9f51b323300d
http://www.sciencedirect.com/science/article/pii/S2212877819309330
http://www.sciencedirect.com/science/article/pii/S2212877819309330
Autor:
Bruce D. Levy, Yan Bai, Charles N. Serhan, Raja-Elie E. Abdulnour, Xingbin Ai, Paul C. Norris, Thayse Regina Brüggemann, Alexander H. Tavares
Publikováno v:
J Allergy Clin Immunol
Background Cysteinyl leukotrienes (CysLTs) are potent prophlogistic mediators in asthmatic patients; however, inhibition of CysLT receptor 1 is not a consistently effective treatment, suggesting additional regulatory mechanisms. Other cysteinyl-conta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a2819075b3d4f9e2fdce8227226324
https://doi.org/10.1016/j.jaci.2019.09.028
https://doi.org/10.1016/j.jaci.2019.09.028