Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Paul C, Holland"'
Publikováno v:
Developmental Neurobiology. 73:333-353
In response to a wound, astrocytes in culture extend microtubule-rich processes and polarize, orienting their centrosomes and Golgi apparatus woundside. β1 Integrin null astrocytes fail to extend processes toward the wound, and are disoriented, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a47168d68fbff5d7acec49d76b108b5
https://doi.org/10.1002/dneu.22055
https://doi.org/10.1002/dneu.22055
Publikováno v:
Developmental Neurobiology. 68:559-574
Monolayers of astrocytes in culture respond to a scrape wound by orienting towards the wound and extending processes that will repair it. We show here that they also upregulate the expression of extracellular matrix (ECM) proteins, laminin, and chond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b906de76296ef7e95f711f01d3f0e6
https://doi.org/10.1002/dneu.20593
https://doi.org/10.1002/dneu.20593
Autor:
Josephine Nalbantoglu, Rénald Gilbert, Won Kyung Cho, George Karpati, Basil J. Petrof, Paul C. Holland, Bernard Massie, Satoru Ebihara
Publikováno v:
Human Gene Therapy. 11:701-714
Duchenne muscular dystrophy (DMD) and other inherited myopathies lead to progressive destruction of most skeletal muscles in the body, including those responsible for maintaining respiration. DMD is a fatal disorder caused by defects in the dystrophi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950c826112fd7e04191143562f59060f
https://doi.org/10.1089/10430340050015608
https://doi.org/10.1089/10430340050015608
Publikováno v:
Human Gene Therapy. 10:1009-1019
Skeletal muscle fibers are infected efficiently by adenoviral vectors only in neonatal animals. This lack of tropism for mature skeletal muscle may be partly due to inefficient binding of adenoviral particles to the cell surface. We evaluated in deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ccb8a30b2eb0273aa78b0690be29f0
https://doi.org/10.1089/10430349950018409
https://doi.org/10.1089/10430349950018409
Autor:
Johnny Huard, Hanns Lochmüller, Agnes Jani, Bernard Massie, Gyula Acsadi, Claude Guérin, George Karpati, Paul C. Holland
Publikováno v:
Experimental and Molecular Pathology. 62:131-143
We demonstrated different transduction efficiency in several major organs of the immature (newborn) versus mature (adult) mice using adenoviral recombinants containing expression cassettes for either firefly luciferase or bacterial β-galactosidase r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8c853246db18efc3fbdc3803ee5563
https://doi.org/10.1006/exmp.1995.1015
https://doi.org/10.1006/exmp.1995.1015
Publikováno v:
Neuromuscular Disorders. 5:105-114
Human muscle cultures undergo a long-term loss of myotubes and a decline in dystrophin content, which can be prevented by glucocorticoid treatment of the cultures. We confirmed these findings and extended them to show that the utrophin content of con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f41d963c212d97d74d5dcda808808b0
https://doi.org/10.1016/0960-8966(94)00042-8
https://doi.org/10.1016/0960-8966(94)00042-8
Autor:
Paul C. Holland, Claude W. Guérin
Publikováno v:
Developmental Dynamics. 202:91-99
The expression of matrix-degrading metalloproteases (MMPs) by human skeletal muscle satellite cells was investigated by zymography of cell culture media and by Northern blot analysis of mRNA prepared from satellite cells. Zymography in gelatin substr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809faf9f29342a7a80962e61e9f25ea7
https://doi.org/10.1002/aja.1002020109
https://doi.org/10.1002/aja.1002020109
Publikováno v:
Developmental neurobiology. 73(5)
In response to a wound, astrocytes in culture extend microtubule-rich processes and polarize, orienting their centrosomes and Golgi apparatus woundside. β1 Integrin null astrocytes fail to extend processes toward the wound, and are disoriented, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::55dd5b7dddd473e422f1525a18ff902a
https://pubmed.ncbi.nlm.nih.gov/22949126
https://pubmed.ncbi.nlm.nih.gov/22949126
Publikováno v:
Molecular and Cellular Biochemistry. 130:57-65
Dystrophin is a high molecular weight protein present at low abundance in skeletal, cardiac and smooth muscle and in trace amounts in brain. In skeletal muscle, dystrophin is uniformly distributed along the inner surface of the plasma membrane. Bioch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519e4f9d3bf4772e01bfd0bfd21fdbff
https://doi.org/10.1007/bf01084268
https://doi.org/10.1007/bf01084268
Autor:
George Karpati, Paul C. Holland
Publikováno v:
Neurology. 59:1674-1676
Three papers in this issue of Neurology 1-3⇓⇓ and one that appeared 3 months ago4 report patients with newly discovered diseases of protein glycosylation. Glycosylation is a post-translational modification of proteins to form glycoproteins, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f316f271cbd6985b1bf7b96e9ead1f02
https://doi.org/10.1212/01.wnl.0000041160.67746.f6
https://doi.org/10.1212/01.wnl.0000041160.67746.f6