Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Paul Buule"'
HIV-1 subtype A1, D, and recombinant proviral genome landscapes during long-term suppressive therapy
Autor:
Guinevere Q. Lee, Pragya Khadka, Sarah N. Gowanlock, Dennis C. Copertino, Maggie C. Duncan, F. Harrison Omondi, Natalie N. Kinloch, Jingo Kasule, Taddeo Kityamuweesi, Paul Buule, Samiri Jamiru, Stephen Tomusange, Aggrey Anok, Zhengming Chen, R. Brad Jones, Ronald M. Galiwango, Steven J. Reynolds, Thomas C. Quinn, Zabrina L. Brumme, Andrew D. Redd, Jessica L. Prodger
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The primary obstacle to curing HIV-1 is a reservoir of CD4+ cells that contain stably integrated provirus. Previous studies characterizing the proviral landscape, which have been predominantly conducted in males in the United States and Euro
Externí odkaz:
https://doaj.org/article/8753461e8307400b835f50ad980f61a1
Autor:
Minh Ha Ngo, Joshua Pankrac, Ryan C. Y. Ho, Emmanuel Ndashimye, Rahul Pawa, Renata Ceccacci, Tsigereda Biru, Abayomi S. Olabode, Katja Klein, Yue Li, Colin Kovacs, Robert Assad, Jeffrey M. Jacobson, David H. Canaday, Stephen Tomusange, Samiri Jamiru, Aggrey Anok, Taddeo Kityamuweesi, Paul Buule, Ronald M. Galiwango, Steven J. Reynolds, Thomas C. Quinn, Andrew D. Redd, Jessica L. Prodger, Jamie F. S. Mann, Eric J. Arts
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
ABSTRACTTo date, an affordable, effective treatment for an HIV-1 cure remains only a concept with most “latency reversal” agents (LRAs) lacking specificity for the latent HIV-1 reservoir and failing in early clinical trials. We assessed HIV-1 lat
Externí odkaz:
https://doaj.org/article/c4e48e2d64a24cd4aecbe0e0f13130b6
Autor:
Roux-Cil Ferreira, Steven J. Reynolds, Adam A. Capoferri, Owen R. Baker, Erin E. Brown, Ethan Klock, Jernelle Miller, Jun Lai, Sharada Saraf, Charles Kirby, Briana Lynch, Jada Hackman, Sarah N. Gowanlock, Stephen Tomusange, Samiri Jamiru, Aggrey Anok, Taddeo Kityamuweesi, Paul Buule, Daniel Bruno, Craig Martens, Rebecca Rose, Susanna L. Lamers, Ronald M. Galiwango, Art F.Y. Poon, Thomas C. Quinn, Jessica L. Prodger, Andrew D. Redd
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105040- (2024)
Summary: Background: The principal barrier to an HIV cure is the presence of the latent viral reservoir (LVR), which has been understudied in African populations. From 2018 to 2019, Uganda instituted a nationwide rollout of ART consisting of Dolutegr
Externí odkaz:
https://doaj.org/article/7fa7f6eb718b411a877cdd47fd239934
Autor:
Roux-Cil Ferreira, Steven J. Reynolds, Adam A. Capoferri, Owen Baker, Erin E. Brown, Ethan Klock, Jernelle Miller, Jun Lai, Sharada Saraf, Charles Kirby, Briana Lynch, Jada Hackman, Sarah N. Gowanlock, Stephen Tomusange, Samiri Jamiru, Aggrey Anok, Taddeo Kityamuweesi, Paul Buule, Daniel Bruno, Craig Martens, Rebecca Rose, Susanna L. Lamers, Ronald M. Galiwango, Art F. Y. Poon, Thomas C. Quinn, Jessica L. Prodger, Andrew D. Redd
Publikováno v:
medRxiv
The principal barrier to an HIV cure is the presence of a latent viral reservoir (LVR) made up primarily of latently infected resting CD4+ (rCD4) T-cells. Studies in the United States have shown that the LVR decays slowly (half-life=3.8 years), but t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90224c973a1651f36a6602a6f26f36e
https://europepmc.org/articles/PMC10246077/
https://europepmc.org/articles/PMC10246077/
Reduced HIV-1 latent reservoir outgrowth and distinct immune correlates among women in Rakai, Uganda
Autor:
Adam A. Capoferri, David Serwadda, Katherine E. Schlusser, Thomas C. Quinn, Yun Hee Choi, Steven J. Reynolds, Jingo Kasule, Paul Buule, Jun Lai, Kyungyoon J. Kwon, Taddeo Kityamuweesi, Andrew D. Redd, Katherine Yu, Craig Martens, Jessica L. Prodger, Eileen P. Scully
Publikováno v:
JCI Insight
HIV-1 infection remains incurable owing to the persistence of a viral reservoir that harbors integrated provirus within host cellular DNA. Increasing evidence links sex-based differences in HIV-1 immune responses and pathogenesis; however, little is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1b448e22e428587f199aed2ee0bab0
https://doi.org/10.1172/jci.insight.139287
https://doi.org/10.1172/jci.insight.139287
Autor:
Robert F. Siliciano, Jeanne C. Keruly, Andrew D. Redd, Richard D. Moore, Stephen F. Porcella, Steven J. Reynolds, Adam A. Capoferri, David Serwadda, Jingo Kasule, Janet D. Siliciano, Thomas C. Quinn, Martha Nason, Paul Buule, Jun Lai, Taddeo Kityamuweesi, Jessica L. Prodger
Background Human immunodeficiency virus type 1 (HIV-1) persists in latently infected resting CD4+ T cells (rCD4 cells), posing a major barrier to curing HIV-1 infection. Previous studies have quantified this pool of latently infected cells in America
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc97f4a72ba944cc6139bb780d834f2
https://europepmc.org/articles/PMC5850010/
https://europepmc.org/articles/PMC5850010/