Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Paul Burgman"'
Autor:
Guangzhi Sui, Paul Burgman, Arun B. Deora, Katherine A. Hajjar, Peng Hong, Kang Chen, Kai Li He, Bihui Huang, Andrew T. Jacovina, Dena Almeida
Publikováno v:
Blood. 118:2918-2929
Oxygen-induced retinopathy (OIR) is a well-characterized model for retinopathy of prematurity, a disorder that results from rapid microvascular proliferation after exposure of the retina to high oxygen levels. Here, we report that the proliferative p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509141d5d631ba901555ba8575155e83
https://doi.org/10.1182/blood-2011-03-341214
https://doi.org/10.1182/blood-2011-03-341214
Autor:
Paul Burgman, Qing Chen, James A. Russell, Juan A Diaz-Gonzalez, Kyung Hwan Shin, Xiaofeng Li, C. Cliffton Ling
Publikováno v:
Cancer Biology & Therapy. 6:70-75
We have used immunohistochemistry to examine the dynamics of tumor hypoxia.. Expression of CAIX is known to be influenced by tumor hypoxia, and this protein has been shown to be an endogenous hypoxia marker in several models. However, due to its long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e626824771d2575c1bbe4019deaf8c54
https://doi.org/10.4161/cbt.6.1.3550
https://doi.org/10.4161/cbt.6.1.3550
Autor:
Paul Burgman, C. Clifton Ling, John L. Humm, Joseph A. O'Donoghue, Michael J. Welch, Jason S. Lewis
Publikováno v:
Nuclear Medicine and Biology. 32:623-630
Background Cu-diacetyl-bis( N 4 -methylthiosemicarbazone) [Cu-ATSM] is a potential marker for tumor hypoxia that has been under evaluation for clinical use. In this study, we examined the mechanisms underlying the uptake of 64 Cu in cells incubated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c787a875d75f55a5072bcd2dc71bc73e
https://doi.org/10.1016/j.nucmedbio.2005.05.003
https://doi.org/10.1016/j.nucmedbio.2005.05.003
Autor:
Shutian Ruan, John L. Humm, C. Clifton Ling, Bixiu Wen, Pat Zanzonico, Jason S. Lewis, Shangde Cai, Andrei Pugachev, Peter Smith-Jones, Joseph A. O'Donoghue, Paul Burgman, Eva Burnazi, Ronald D. Finn, Michael J. Welch
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 61:1493-1502
Purpose: To compare two potential positron emission tomography (PET) tracers of tumor hypoxia in an animal model. Methods and Materials: The purported hypoxia imaging agents 18F-fluoromisonidazole (FMISO) and 64Cu(II)-diacetyl-bis(N4-methylthiosemica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064a9c025b1fae1656e5608e76ed3467
https://doi.org/10.1016/j.ijrobp.2004.12.057
https://doi.org/10.1016/j.ijrobp.2004.12.057
Autor:
Ronald D. Finn, Gloria C. Li, Paul Burgman, Shangde Cai, Bixiu Wen, Juri Gelovani, C. Clifton Ling, Joseph A. O'Donoghue, Ronald G. Blasberg, Inna Serganova, Pat Zanzonico
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 31:1530-1538
Hypoxia is associated with tumor aggressiveness and is an important cause of resistance to radiation therapy and chemotherapy. Assays of tumor hypoxia could provide selection tools for hypoxia-modifying treatments. The purpose of this study was to de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75b04fa37fcbe90c5eca46f476133b1
https://doi.org/10.1007/s00259-004-1673-z
https://doi.org/10.1007/s00259-004-1673-z
Autor:
Honghai Ouyang, Dooha Kim, Gloria C. Li, Ligeng Li, André Nussenzweig, Paul Burgman, Shao-Hua Yang
Publikováno v:
Molecular and Cellular Biology. 16:3799-3806
Previously, we proposed a dual control mechanism for the regulation of the heat shock response in mammalian cells: a positive control mediated by the heat shock transcription factor HSF1 and a negative control mediated by the constitutive heat shock
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8bfad05a4cc3520c81c06c459473933
https://doi.org/10.1128/mcb.16.7.3799
https://doi.org/10.1128/mcb.16.7.3799
Autor:
Gloria C. Li, Shao-Hua Yang, Honghai Ouyang, André Nussenzweig, Ligeng Li, June Wei, Dooha Kim, Paul Burgman
Publikováno v:
Proceedings of the National Academy of Sciences. 92:4512-4516
Expression of the 70-kDa polypeptide of human Ku autoantigen in rat cells is shown to suppress specifically the induction of hsp70 upon heat shock. Thermal induction of other heat shock proteins is not significantly affected, nor is the state of phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d702ed1202a15a5352b6accc74327827
https://doi.org/10.1073/pnas.92.10.4512
https://doi.org/10.1073/pnas.92.10.4512
Publikováno v:
International journal of radiation biology. 88(7)
To study the effect of DN (dominant-negative) Ku70 and reoxygenation on the hypoxia-induced cell-kill.Cell lines were human colorectal carcinoma HCT8 and HT29 cells and their respective derivatives, v-HCT8 and v-HT29 infected with DNKu70-containing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e750f5c395ca188db4b21b6d2cebe548
https://pubmed.ncbi.nlm.nih.gov/22617044
https://pubmed.ncbi.nlm.nih.gov/22617044
Autor:
Joseph A. O'Donoghue, Guangbin Yang, C. Clifton Ling, Sean Burke, Paul Burgman, Christoph Oehler-Janne, Sean Carlin, Makiko Suehiro, John L. Humm, Ouathek Ouerfelli
INTRODUCTION: The hypoxia marker IAZGP, 1-(6-deoxy-6-iodo-beta-d-galactopyranosyl)-2-nitroimidazole, has been labeled with (123)I/(124)I/(125)I/(131)I via iodine-radioiodine exchange, which gives the radiotracer in a specific activity of 10-90 MBq/mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4e432c9133aff371d52732bef20cd6
https://www.zora.uzh.ch/id/eprint/28403/
https://www.zora.uzh.ch/id/eprint/28403/
Autor:
Paul Burgman, Jacek Koziorowski, Jason A. Koutcher, C. Clifton Ling, Daniel Procissi, Filip Claus, Cornelia Matei, Sunitha B. Thakur, J. Donald Chapman
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 13(12)
Purpose: 2-Nitro-α-[(2,2,2-trifluoroethoxy)methyl]-imidazole-1-ethanol (TF-MISO) was investigated as a potential noninvasive marker of tissue oxygen levels in tumors using 19F magnetic resonance spectroscopy (MRS) and 19F chemical shift imaging. Exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef477951d8133222469878641efc1513
https://pubmed.ncbi.nlm.nih.gov/17575240
https://pubmed.ncbi.nlm.nih.gov/17575240