Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Paul Brust"'
Autor:
Faber Nathan, Alain Noncovich, Guy Servant, Nicole Gonsalves, Paul Brust, Tanya Ditschun, Jane Ung, Andrew Patron, Hanghui Liu, Nicole Servant, Chad Priest
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3931-3938
The paper presents the activity trends for a novel series of phenoxyacetyl amides as human TRPM8 receptor agonists. This series encompasses in vitro activity values ranging from the micromolar to the picomolar levels. Sensory evaluation of these mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b055d78c3adc8356a22f49b490adfa
https://doi.org/10.1016/j.bmcl.2017.04.003
https://doi.org/10.1016/j.bmcl.2017.04.003
Autor:
Kenneth A. Stauderman, Paul Brust, Bruno Hivert, Mark E. Williams, Michael M. Harpold, Michele Spagnolo, Siro Luvisetto, Tommaso Fellin, Daniela Pietrobon
Publikováno v:
Journal of General Physiology. 124:445-461
The single channel gating properties of human CaV2.1 (P/Q-type) calcium channels and their modulation by the auxiliary β1b, β2e, β3a, and β4a subunits were investigated with cell-attached patch-clamp recordings on HEK293 cells stably expressing h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2354d2ad7df382ef0e7a40ab7c3e427b
https://doi.org/10.1085/jgp.200409034
https://doi.org/10.1085/jgp.200409034
Autor:
Daniela Pietrobon, Siro Luvisetto, Angelita Tottene, Paul Brust, Mark E. Williams, Michele Spagnolo, Edwin C. Johnson, Michael Hans, Michael M. Harpold, Arturo Urrutia, Kenneth A. Stauderman
Publikováno v:
The Journal of Neuroscience. 19:1610-1619
Mutations in α1A, the pore-forming subunit of P/Q-type calcium channels, are linked to several human diseases, including familial hemiplegic migraine (FHM). We introduced the four missense mutations linked to FHM into human α1A-2subunits and invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93349b0d6ebacafbf074b9bb32275544
https://doi.org/10.1523/jneurosci.19-05-01610.1999
https://doi.org/10.1523/jneurosci.19-05-01610.1999
Autor:
Charles R. Deal, Steven B. Ellis, Michael Hans, Arturo Urrutia, Kenneth A. Stauderman, Mark E. Williams, Paul Brust, Edwin C. Johnson, Michael M. Harpold
Publikováno v:
Biophysical Journal. 76:1384-1400
We have cloned two splice variants of the human homolog of the alpha1A subunit of voltage-gated Ca2+ channels. The sequences of human alpha1A-1 and alpha1A-2 code for proteins of 2510 and 2662 amino acids, respectively. Human alpha1A-2alpha2bdeltabet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0376539f1635b5f24ab60e09fbecda
https://doi.org/10.1016/s0006-3495(99)77300-5
https://doi.org/10.1016/s0006-3495(99)77300-5
Autor:
Kenneth A. Stauderman, Arturo Urrutia, Michael M. Harpold, Paul Brust, Mark E. Williams, Patricia Prodanovich, Michael Hans, Mark S. Washburn
Publikováno v:
Journal of Neurochemistry. 72:791-799
We have isolated and characterized overlapping cDNAs encoding a novel, voltage-gated Ca2+ channel alpha1 subunit, alpha1H, from a human medullary thyroid carcinoma cell line. The alpha1H subunit is structurally similar to previously described alpha1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ae0425322000fedbde2436f2353fbf
https://doi.org/10.1046/j.1471-4159.1999.0720791.x
https://doi.org/10.1046/j.1471-4159.1999.0720791.x
Autor:
Bethan Lang, David Bleakman, John Newsom-Davis, David M. Lodge, Paul Brust, Fraser J. Moss, Samantha E. Gillard, Ashwin Pinto, Mark Williams, Kenneth A. Stauderman, Michael M. Harpold, Kathryn Whyte, John Boot
Publikováno v:
Proceedings of the National Academy of Sciences. 95:8328-8333
The pharmacological properties of voltage-dependent calcium channel (VDCC) subtypes appear mainly to be determined by the α 1 pore-forming subunit but, whether P-and Q-type VDCCs are encoded by the same α 1 gene presently is unresolved. To investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0224a61191a5b33286234cf78b430f8
https://doi.org/10.1073/pnas.95.14.8328
https://doi.org/10.1073/pnas.95.14.8328
Autor:
Mark Williams, Bethan Lang, John Boot, Kenneth A. Stauderman, Fraser J. Moss, John Newsom-Davis, Ashwin Pinto, Paul Brust, Michael M. Harpold
Publikováno v:
Annals of the New York Academy of Sciences. 841:687-690
Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder in which antibodies to presynaptic calcium channels at the neuromuscular junction lead to muscle weakness. Around 60% of patients with LEMS have an associated small cell lung carcinom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cdcda1c8017fd61bd218985fe500be1
https://doi.org/10.1111/j.1749-6632.1998.tb11003.x
https://doi.org/10.1111/j.1749-6632.1998.tb11003.x
Autor:
Paul Brust, Kathy G. Sutton, Roderick H. Scott, Jeremy Gilmore, Graham Henry Timms, Simon R. Stapleton, David Bleakman
Publikováno v:
Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology. 116:23-32
The whole cell variant of the patch-clamp technique was used to investigate the actions of polyamine spider toxins and their analogues on high voltage-activated Ca 2+ currents. The actions of synthesised FTX (putative natural toxin from the American
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8d050abab88972da16809a979a66225
https://doi.org/10.1016/s0742-8413(96)00141-7
https://doi.org/10.1016/s0742-8413(96)00141-7
Autor:
Paul Brust, Michael M. Harpold, Louis H. Philipson, Edwin C. Johnson, Richard J. Miller, Mark E. Williams, Charles R. Deal, Steven B. Ellis, Michael Hans, Lisa M. Marubio
Publikováno v:
Journal of Biological Chemistry. 269:22347-22357
We have cloned overlapping cDNAs encoding alpha 1E Ca2+ channel subunits from mouse and human brain. We observed that these alpha 1E transcripts were widely distributed in the central nervous system. We also demonstrated the existence of two variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c19df59d4c9db9a5ae787db9c53a536b
https://doi.org/10.1016/s0021-9258(17)31796-9
https://doi.org/10.1016/s0021-9258(17)31796-9
Autor:
Goran Petrovic, Feng Zhang, Xiao-Qing Tang, Catherine Tachdjian, Grant E. Dubois, Tanya Ditschun, Sara Werner, Mark Zoller, Poonit Kamdar, Paul Brust, Donald S. Karanewsky, Guy Servant, Antoniette Java, Xiaodong Li, Nicole Brune
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 107(10)
To identify molecules that could enhance sweetness perception, we undertook the screening of a compound library using a cell-based assay for the human sweet taste receptor and a panel of selected sweeteners. In one of these screens we found a hit, SE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d2ae7fdd116ea297cfa5ef6aa93369
https://pubmed.ncbi.nlm.nih.gov/20173092
https://pubmed.ncbi.nlm.nih.gov/20173092