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of 68
pro vyhledávání: '"Paul Brownbill"'
Targeted Delivery of Epidermal Growth Factor to the Human Placenta to Treat Fetal Growth Restriction
Autor:
Lewis J. Renshall, Frances Beards, Angelos Evangelinos, Susan L. Greenwood, Paul Brownbill, Adam Stevens, Colin P. Sibley, John D. Aplin, Edward D. Johnstone, Tambet Teesalu, Lynda K. Harris
Publikováno v:
Pharmaceutics, Vol 13, Iss 11, p 1778 (2021)
Placental dysfunction is the underlying cause of pregnancy complications such as fetal growth restriction (FGR) and pre-eclampsia. No therapies are available to treat a poorly functioning placenta, primarily due to the risks of adverse side effects i
Externí odkaz:
https://doaj.org/article/31d09fe8761e42b3bf935d5bee54fcfc
Autor:
Philip Pearce, Paul Brownbill, Jiří Janáček, Marie Jirkovská, Lucie Kubínová, Igor L Chernyavsky, Oliver E Jensen
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0165369 (2016)
During pregnancy, oxygen diffuses from maternal to fetal blood through villous trees in the placenta. In this paper, we simulate blood flow and oxygen transfer in feto-placental capillaries by converting three-dimensional representations of villous a
Externí odkaz:
https://doaj.org/article/5a37cc9e245d4b71be0e5d8dc4e7a4bc
Autor:
Paul Brownbill
Publikováno v:
Body, Space & Technology Journal, Vol 6, Iss 2 (2007)
Externí odkaz:
https://doaj.org/article/21170d2a2c814d84967d0649a8706318
Publikováno v:
Placenta. 130:1-8
Pregnancy pathologies including gestational diabetes, intrauterine fetal growth restriction, and pre-eclampsia are common and significantly increase the risk of poor pregnancy outcomes. Research to better understand the pathophysiology and improve di
Publikováno v:
Placenta. 107:8-12
This is an introductory chapter for the Special Issue: Ex vivo dual perfusion of an isolated cotyledon of the human placenta. It covers the early stages of development of this technique in the laboratory of Professor Maurice Panigel. It was successfu
Publikováno v:
Brownbill, P, Higgins, L & Westwood, M 2020, ' Pulsatility effects of flow on vascular tone in the fetoplacental circulation ', Placenta, vol. 101, pp. 163-168 . https://doi.org/10.1016/j.placenta.2020.09.003
Introduction The regulation of vascular tone in the fetoplacental circulation is governed by endocrine and mechanical forces yielding a relaxed basal state in normal pregnancy. Flow mediated vasodilation, induced by shear stress and endothelial nitri
Autor:
Henning Schneider, Christiane Albrecht, Mahmoud S. Ahmed, Michelle Broekhuizen, Leonie Aengenheister, Tina Buerki-Thurnherr, A.H. Jan Danser, Sophie Gil, Stefan R. Hansson, Rick Greupink, Rohan M. Lewis, Udo R. Markert, Line Mathiesen, Nicola Powles-Glover, Christian Wadsack, Paul Brownbill
Publikováno v:
Schneider, Henning; Albrecht, Christiane; Ahmed, Mahmoud S; Broekhuizen, Michelle; Aengenheister, Leonie; Buerki-Thurnherr, Tina; Danser, A H Jan; Gil, Sophie; Hansson, Stefan R; Greupink, Rick; Lewis, Rohan M; Markert, Udo R; Mathiesen, Line; Powles-Glover, Nicola; Wadsack, Christian; Brownbill, Paul (2022). Ex vivo dual perfusion of an isolated human placenta cotyledon: Towards protocol standardization and improved inter-centre comparability. Placenta, 126, pp. 83-89. Elsevier 10.1016/j.placenta.2022.05.003
Placenta, 126, 83-89. W.B. Saunders
Schneider, H, Albrecht, C, Ahmed, M S, Broekhuizen, M, Aengenheister, L, Buerki-Thurnherr, T, Danserf, A H J, Gil, S, Hansson, S R, Greupink, R, Lewis, R M, Markert, U R, Mathiesen, L, Powles-Glover, N, Wadsack, C & Brownbill, P 2022, ' Ex vivo dual perfusion of an isolated human placenta cotyledon : Towards protocol standardization and improved inter-centre comparability ', Placenta, vol. 126, pp. 83-89 . https://doi.org/10.1016/j.placenta.2022.05.003
Placenta, 126, pp. 83-89
Placenta, 126, 83-89
Placenta, 126, 83-89. W.B. Saunders
Schneider, H, Albrecht, C, Ahmed, M S, Broekhuizen, M, Aengenheister, L, Buerki-Thurnherr, T, Danserf, A H J, Gil, S, Hansson, S R, Greupink, R, Lewis, R M, Markert, U R, Mathiesen, L, Powles-Glover, N, Wadsack, C & Brownbill, P 2022, ' Ex vivo dual perfusion of an isolated human placenta cotyledon : Towards protocol standardization and improved inter-centre comparability ', Placenta, vol. 126, pp. 83-89 . https://doi.org/10.1016/j.placenta.2022.05.003
Placenta, 126, pp. 83-89
Placenta, 126, 83-89
Since the full development of the ex vivo dual perfusion model of the human placenta cotyledon, the technique has provided essential insight into how nutrients, lipids, gases, immunoglobulins, endocrine agents, pharma-ceuticals, chemicals, nanopartic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55d227133410973048f691e2c344bb3
Targeted Delivery of Epidermal Growth Factor to the Human Placenta to Treat Fetal Growth Restriction
Autor:
Adam Stevens, John D. Aplin, Edward D. Johnstone, Susan L. Greenwood, Tambet Teesalu, Colin P. Sibley, Lynda K. Harris, Angelos Evangelinos, Frances Beards, Lewis Renshall, Paul Brownbill
Publikováno v:
Pharmaceutics
Pharmaceutics, Vol 13, Iss 1778, p 1778 (2021)
Renshall, L J, Beards, F, Evangelinos, A, Greenwood, S L, Brownbill, P, Stevens, A, Sibley, C P, Aplin, J D, Johnstone, E D, Teesalu, T & Harris, L K 2021, ' Targeted Delivery of Epidermal Growth Factor to the Human Placenta to Treat Fetal Growth Restriction ', Pharmaceutics, vol. 13, no. 11, pp. 1778 . https://doi.org/10.3390/pharmaceutics13111778
Volume 13
Issue 11
Pharmaceutics, Vol 13, Iss 1778, p 1778 (2021)
Renshall, L J, Beards, F, Evangelinos, A, Greenwood, S L, Brownbill, P, Stevens, A, Sibley, C P, Aplin, J D, Johnstone, E D, Teesalu, T & Harris, L K 2021, ' Targeted Delivery of Epidermal Growth Factor to the Human Placenta to Treat Fetal Growth Restriction ', Pharmaceutics, vol. 13, no. 11, pp. 1778 . https://doi.org/10.3390/pharmaceutics13111778
Volume 13
Issue 11
Placental dysfunction is the underlying cause of pregnancy complications such as fetal growth restriction (FGR) and pre-eclampsia. No therapies are available to treat a poorly functioning placenta, primarily due to the risks of adverse side effects i
Autor:
Paddy Slator, Rosalind Aughwane, Georgina Cade, Daniel Taylor, Anna L. David, Rohan Lewis, Eric Jauniaux, Adrien Desjardins, Laurent J. Salomon, Anne-Elodie Millischer, Vassilis Tsatsaris, Mary Rutherford, Edward D. Johnstone, Andrew Melbourne, David Atkinson, Rupanjali Baranikumar, Charline Bertholdt, Elisenda Bonet-Carne, Paul Brownbill, Muriel Bruchhage, Richard Caulfield, Igor Chernyavsky, Andrew Chew, Anna David, Enrico De Vita, Tom Doel, Alexander Erlich, Dimitra Flouri, Michele Guerreri, Matina Hakim, Ditte Hansen, Makinah Haq, Parvez Haris, Sara Hillman, Alison Ho, Jana Hutter, Laurence Jackson, Edward Johnstone, Esra Kipergil, Silvia Labianco, Christina Malamateniou, Efthymios Maneas, Enrique Monton, David Morris, Julie Nihouarn, Gareth Nye, Helen O'Neill, Mette Østergaard Thunbo, Marco Palombo, Rachel Peasley, Kelly Pegoretti Baruteau, Romina Plitman Mayo, Saskia Port, Laurent Salomon, Simon Shah, Natalia Soe, Anne Soerensen, Magdalena Sokolska, Carla Svigilsky, Teresa Tropea, Guotai Wang, Bilal Yassine
Publikováno v:
Placenta
Slator, P, Aughwane, R, Cade, G, Taylor, D, David, A L, Lewis, R, Jauniaux, E, Desjardins, A, Salomon, L J, Millischer, A-E, Tsatsaris, V, Rutherford, M, Johnstone, E, Melbourne, A, Atkinson, D, Baranikumar, R, Bertholdt, C, Bonet-Carne, E, Brownbill, P, Bruchhage, M, Caulfield, R, Chernyavsky, I, Chew, A, David, A, De Vita, E, Doel, T, Erlich, A, Flouri, D, Guerreri, M, Hakim, M, Hansen, D, Haq, M, Haris, P, Hillman, S, Ho, A, Hutter, J, Jackson, L, Johnstone, E, Kipergil, E, Labianco, S, Malamateniou, C, Maneas, E, Monton, E, Morris, D, Nihouarn, J, Nye, G, O'Neill, H, Thunbo, M Ø, Palombo, M, Peasley, R, Baruteau, K P, Mayo, R P, Port, S, Salomon, L, Shah, S, Soe, N, Soerensen, A, Sokolska, M, Svigilsky, C, Tropea, T, Wang, G & Yassine, B 2018, ' Placenta Imaging Workshop 2018 report : Multiscale and multimodal approaches ', Placenta, vol. 79, pp. 78-82 . https://doi.org/10.1016/j.placenta.2018.10.010
Slator, P, Aughwane, R, Cade, G, Taylor, D, David, A L, Lewis, R, Jauniaux, E, Desjardins, A, Salomon, L J, Millischer, A-E, Tsatsaris, V, Rutherford, M, Johnstone, E, Melbourne, A, Atkinson, D, Baranikumar, R, Bertholdt, C, Bonet-Carne, E, Brownbill, P, Bruchhage, M, Caulfield, R, Chernyavsky, I, Chew, A, David, A, De Vita, E, Doel, T, Erlich, A, Flouri, D, Guerreri, M, Hakim, M, Hansen, D, Haq, M, Haris, P, Hillman, S, Ho, A, Hutter, J, Jackson, L, Johnstone, E, Kipergil, E, Labianco, S, Malamateniou, C, Maneas, E, Monton, E, Morris, D, Nihouarn, J, Nye, G, O'Neill, H, Thunbo, M Ø, Palombo, M, Peasley, R, Baruteau, K P, Mayo, R P, Port, S, Salomon, L, Shah, S, Soe, N, Soerensen, A, Sokolska, M, Svigilsky, C, Tropea, T, Wang, G & Yassine, B 2018, ' Placenta Imaging Workshop 2018 report : Multiscale and multimodal approaches ', Placenta, vol. 79, pp. 78-82 . https://doi.org/10.1016/j.placenta.2018.10.010
The Centre for Medical Image Computing (CMIC) at University College London (UCL) hosted a two-day workshop on placenta imaging on April 12th and 13th 2018. The workshop consisted of 10 invited talks, 3 contributed talks, a poster session, a public in
Autor:
Michele C. Darrow, Oliver N. King, Igor L. Chernyavsky, Edward D. Johnstone, Yasuaki Tokudome, Gowsihan Poologasundarampillai, William M Tun, Helen Bischof, Paul Brownbill, Rohan M. Lewis, Gareth A. Nye, Mark Basham
Publikováno v:
Journal of the Royal Society Interface
Multi-scale structural assessment of biological soft tissue is challenging but essential to gain insight into structure-function relationships of tissue/organ. Using the human placenta as an example, this study brings together sophisticated sample pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e556571cf96480c8d40d80d34b4e90
https://doi.org/10.1101/2020.12.07.411462
https://doi.org/10.1101/2020.12.07.411462