Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Paul Bowness"'
Autor:
Ariane Hammitzsch, Andreas Ossadnik, Quirin Bachmann, Helga Merwald-Fraenk, Georg Lorenz, Matthias Witt, Franziska Wiesent, Heinrich Mühlhofer, Davide Simone, Paul Bowness, Uwe Heemann, Martin Arbogast, Philipp Moog, Christoph Schmaderer
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
ObjectivesIL26 levels are elevated in the blood and synovial fluid of patients with inflammatory arthritis. IL26 can be produced by Th17 cells and locally within joints by tissue-resident cells. IL26 induces osteoblast mineralization in vitro. As ost
Externí odkaz:
https://doaj.org/article/8feb2152c9f3484593b31d2291a42fe7
Autor:
Iain B McInnes, Stefan Siebert, Paul Bowness, Laura C Coates, Anne Francis, Bruce W Kirkham, Alexander Ooms, Hussein Al-Mossawi, Louise Bennett, Nicole Yager, Duncan Richards, Mimi Bogale, Carl Goodyear, Sylvine Lalnunhlimi, Leonie S Taams, Aysin Tulunay Virlan
Publikováno v:
BMJ Open, Vol 13, Iss 9 (2023)
Introduction Psoriatic arthritis (PsA) affects around 150 000 people in the UK of whom around 50% require treatment with biologics. The most used biologics for PsA target tumour necrosis factor (TNF) or interleukin-17A (IL-17A). About 50% of patients
Externí odkaz:
https://doaj.org/article/fec1e3e94bdb470b8bf658b6414ae65c
Autor:
Davide Simone, Frank Penkava, Anna Ridley, Stephen Sansom, M. Hussein Al-Mossawi, Paul Bowness
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Simone et al. analyze T cell receptor usage and gene expression profiles of CD3+CD45RA-CD25+CD127low blood and synovial fluid regulatory T cells from patients with spondyloarthritis. This work provides a valuable resource for understanding regulatory
Externí odkaz:
https://doaj.org/article/1017ecd1d83e4d1bb04d8c49992125b2
Autor:
Izabela Lenart, Linh-Huyen Truong, Dinh Dung Nguyen, Olga Rasiukienė, Edward Tsao, Jonathan Armstrong, Pankaj Kumar, Kirsty McHugh, Branca I. Pereira, Balraj S. Maan, Malgorzata A. Garstka, Paul Bowness, Neil Blake, Simon J. Powis, Keith Gould, Darren Nesbeth, Antony N. Antoniou
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Peptide-loaded Major Histocompatibility Complex (pMHC) class I molecules can be expressed in a single chain trimeric (SCT) format, composed of a specific peptide fused to the light chain beta-2 microglobulin (β2m) and MHC class I heavy chain (HC) by
Externí odkaz:
https://doaj.org/article/26544435c75247c3bb82baf2f7945318
Autor:
Frank Penkava, Martin Del Castillo Velasco-Herrera, Matthew D. Young, Nicole Yager, Lilian N. Nwosu, Arthur G. Pratt, Alicia Lledo Lara, Charlotte Guzzo, Ash Maroof, Lira Mamanova, Suzanne Cole, Mirjana Efremova, Davide Simone, Andrew Filer, Chrysothemis C. Brown, Andrew L. Croxford, John D. Isaacs, Sarah Teichmann, Paul Bowness, Sam Behjati, M. Hussein Al-Mossawi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Psoriatic arthritis (PsA) commonly affects patients with skin psoriasis, but its pathogenesis is still unclear. Here the authors use two types of single-cells data, mass cytometry and RNA sequencing, to describe the expansion and diversity of synovia
Externí odkaz:
https://doaj.org/article/41e60fd553ac455d9a90df903aa0ed85
Autor:
Carla J. Cohen, Connor Davidson, Carlo Selmi, Paul Bowness, Julian C. Knight, B. Paul Wordsworth, Matteo Vecellio
Publikováno v:
Frontiers in Genetics, Vol 12 (2022)
Background: Ankylosing Spondylitis (AS) is a common form of inflammatory spinal arthritis with a complex aetiology and high heritability, involving more than 100 genetic associations. These include several AS-associated single nucleotide polymorphism
Externí odkaz:
https://doaj.org/article/4ff8b902deb44568b15837a082b96c85
Autor:
Hussein Al-Mossawi, Nicole Yager, Chelsea A. Taylor, Evelyn Lau, Sara Danielli, Jelle de Wit, James Gilchrist, Isar Nassiri, Elise A. Mahe, Wanseon Lee, Laila Rizvi, Seiko Makino, Jane Cheeseman, Matt Neville, Julian C. Knight, Paul Bowness, Benjamin P. Fairfax
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Interleukin-7 (IL-7) is a central cytokine in T cell homeostasis. Here the authors show that allelic variation at rs6897932, an autoimmune GWAS risk allele at IL7R, regulates surface and soluble IL-7R in stimulated monocytes, indicating a function of
Externí odkaz:
https://doaj.org/article/049d83c02bd448feb336fe01a336bc58
Autor:
Hui Shi, Liye Chen, Anna Ridley, Nancy Zaarour, India Brough, Cherilyn Caucci, Julia E. Smith, Paul Bowness
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Objectives: GM-CSF is a pro-inflammatory cytokine with multiple actions predominantly on myeloid cells. Enhanced GM-CSF expression by lymphocytes from patients with Ankylosing Spondylitis (AS) has recently been described, however, its potential patho
Externí odkaz:
https://doaj.org/article/756bc3a7e034412aa8fe740307838b53
Autor:
Oliwia Rysnik, Kirsty McHugh, Leonie van Duivenvoorde, Melissa van Tok, Joel Taurog, Simon Kollnberger, Dominique Baeten, Paul Bowness
Publikováno v:
Data in Brief, Vol 9, Iss C, Pp 100-111 (2016)
Data is presented showing expression of non-conventional (NC) heavy chain forms of B27 in synovial tissues from SpA patients. Data is presented showing the expression patterns of NC-B27 in joint, gastrointestinal and lymphoid tissues from B27 transge
Externí odkaz:
https://doaj.org/article/921e55d8292846cfa1d4c6391c5d6639
Autor:
Vasiliki Lagou, Josselyn E. Garcia-Perez, Ide Smets, Lies Van Horebeek, Marijne Vandebergh, Liye Chen, Klara Mallants, Teresa Prezzemolo, Kelly Hilven, Stephanie Humblet-Baron, Matthieu Moisse, Philip Van Damme, Guy Boeckxstaens, Paul Bowness, Bénédicte Dubois, James Dooley, Adrian Liston, An Goris
Publikováno v:
Cell Reports, Vol 25, Iss 3, Pp 798-810.e6 (2018)
Summary: The immune system is highly diverse, but characterization of its genetic architecture has lagged behind the vast progress made by genome-wide association studies (GWASs) of emergent diseases. Our GWAS for 54 functionally relevant phenotypes
Externí odkaz:
https://doaj.org/article/35cdeeb0f9534e9380dd0c9868623eb4