Purinergic signalling links mechanical breath profile and alveolar mechanics with the pro-inflammatory innate immune response causing ventilation-induced lung injury

Autor: Paul Blankman, Gary F. Nieman, Djo Hasan

Publikováno v: Purinergic Signalling
Purinergic Signalling, 13(3), 363-386. Springer Netherlands

Severe pulmonary infection or vigorous cyclic deformation of the alveolar epithelial type I (AT I) cells by mechanical ventilation leads to massive extracellular ATP release. High levels of extracellular ATP saturate the ATP hydrolysis enzymes CD39 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0ada16458d228993bdd34b75304fec
https://doi.org/10.1007/s11302-017-9564-5

Excessive Extracellular ATP Desensitizes P2Y2 and P2X4 ATP Receptors Provoking Surfactant Impairment Ending in Ventilation-Induced Lung Injury

Autor: Djo Hasan, Atsuko Shono, Gary F. Nieman, Paul Blankman, Michaela Kollisch-Singule, Joshua Satalin, Han Meeder, Toru Kotani, Corstiaan A. den Uil, Philip van der Zee, Peter Somhorst

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 4, p 1185 (2018)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 19(4):1185. Multidisciplinary Digital Publishing Institute (MDPI)

Stretching the alveolar epithelial type I (AT I) cells controls the intercellular signaling for the exocytosis of surfactant by the AT II cells through the extracellular release of adenosine triphosphate (ATP) (purinergic signaling). Extracellular AT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444630450b67effb27ddaae894876121
https://pure.eur.nl/en/publications/af22f0ec-7a91-4104-bebb-cb94edec618c

Ventilation distribution measured with EIT at varying levels of pressure support and Neurally Adjusted Ventilatory Assist in patients with ALI

Autor: Martijn S. van Mourik, Djo Hasan, Diederik Gommers, Paul Blankman

Publikováno v: Intensive Care Medicine, 39(6), 1057-1062. Springer-Verlag

The purpose of this study was to compare the effect of varying levels of assist during pressure support (PSV) and Neurally Adjusted Ventilatory Assist (NAVA) on the aeration of the dependent and non-dependent lung regions by means of Electrical Imped

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93d10a29b310e2b6836afbe529781f1
https://hdl.handle.net/1765/65516

Lung monitoring at the bedside in mechanically ventilated patients

Autor: Diederik Gommers, Paul Blankman

Publikováno v: Current Opinion in Critical Care, 18(3), 261-266. Lippincott Williams & Wilkins

It has become clear that mechanical ventilation itself can cause damage to the lung in critically ill patients, also known as ventilator-induced lung injury (VILI). Insight into the mechanisms of VILI has learned that a compromise must be found betwe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48dff73cc62227b460ed5449752e44a8
https://hdl.handle.net/1765/65456

Ventilation distribution measured with electrical impedance tomography at varying levels of assist during pressure support versus neurally adjusted ventilatory assist in ICU patients

Autor: Djo Hasan, Paul Blankman, Van Mourik, Diederik Gommers

Publikováno v: Critical Care
Europe PubMed Central

Electrical impedance tomography (EIT) is a non-invasive and nonradiating imaging technique, which can be used to visualize ventilation distribution of the lungs and could distinguish between the dependent (dorsal) and nondependent (ventral) parts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4812f61a34516fcda2d7335b69bfcf
http://europepmc.org/articles/PMC3642517