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Differential contribution of chronic binge alcohol and antiretroviral therapy to metabolic dysregulation in SIV-infected male macaques

Autor: Curtis Vande Stouwe, Patricia E. Molina, Jason Dufour, Steve Nelson, Stephen M. Ford, Liz Simon Peter, Garth Cook, Paul Berner, Gregory J. Bagby

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 315:E892-E903

The incidence of alcohol use disorder (AUD) is higher among people living with HIV (PLWH). The advent and continued development of antiretroviral therapy (ART) has significantly reduced mortality, shifting the course of HIV infection to a chronic ill

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f75360ecb812aeda0f7346e691c4892
https://doi.org/10.1152/ajpendo.00175.2018

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Decreased myoblast differentiation in chronic binge alcohol-administered simian immunodeficiency virus-infected male macaques: role of decreased miR-206

Autor: Gregory J. Bagby, Patricia E. Molina, Steve Nelson, C. Vande Stouwe, Liz Simon, Stephen M. Ford, Kejing Song, Paul Berner

Publikováno v: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 313:R240-R250

Skeletal muscle stem cells play a critical role in regeneration of myofibers. We previously demonstrated that chronic binge alcohol (CBA) markedly attenuates myoblast differentiation potential and myogenic gene expression. Muscle-specific microRNAs (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::248cb3863bae481055a1a16ae64c28c6
https://doi.org/10.1152/ajpregu.00146.2017

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Chronic binge alcohol consumption alters myogenic gene expression and reduces in vitro myogenic differentiation potential of myoblasts from rhesus macaques

Autor: Patricia E. Molina, Gregory J. Bagby, Curtis Vande Stouwe, William T. Cefalu, Liz Simon, Jason C Mussell, Jason Dufour, Steve Nelson, Paul Berner, Timothy D. Allerton, Nicole J. LeCapitaine, Stefany D. Primeaux

Publikováno v: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 306:R837-R844

Chronic alcohol abuse is associated with skeletal muscle myopathy. Previously, we demonstrated that chronic binge alcohol (CBA) consumption by rhesus macaques accentuates skeletal muscle wasting at end-stage of simian immunodeficiency virus (SIV) inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4f3987c3dc34fe4909eb36a1262fb54
https://doi.org/10.1152/ajpregu.00502.2013

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IL-21 and IL-10 have redundant roles but differential capacities at different stages of plasma cell generation from human germinal center B cells

Autor: Xin Zhang, Paul Berner, Sun-Ok Yoon, Yong Sung Choi

Publikováno v: Journal of Leukocyte Biology. 86:1311-1318

In the germinal center of lymphoid follicles, IL-10 is more effective in generating terminally differentiated CD138+ PC at the later stage of differentiation than IL-21. The GC is the anatomical site where antigen-activated B cells differentiate into

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433dbf26954b7dfcc7ea66b07e4ad3e6
https://doi.org/10.1189/jlb.0409268

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Notch Ligands Expressed by Follicular Dendritic Cells Protect Germinal Center B Cells from Apoptosis

Autor: Bianca Blom, Yong Sung Choi, Xin Zhang, Sun-Ok Yoon, Paul Berner

Publikováno v: Journal of immunology (Baltimore, Md., 183(1), 352-358. American Association of Immunologists

The Notch signaling pathway is one of the most conserved mechanisms to regulate cell fate in many tissues during development and postnatal life. In the immune system, Notch signaling regulates T and B cell development and modulates the differentiatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::123cfff07b740e61a9d968267357be8e
https://doi.org/10.4049/jimmunol.0803183

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Chronic binge alcohol administration accentuates expression of pro-fibrotic and inflammatory genes in the skeletal muscle of simian immunodeficiency virus-infected macaques

Autor: Paul Berner, Patricia E. Molina, Gregory J. Bagby, Nicole J. LeCapitaine, Jason Dufour, Jovanny Zabaleta, Stephen M. Ford, Steve Nelson, Tracy Y. Dodd, Jason Mussell, Liz Simon

Publikováno v: Alcoholism, clinical and experimental research. 38(11)

Background Chronic binge alcohol (CBA) administration exacerbates skeletal muscle (SKM) wasting at the terminal stage of simian immunodeficiency virus (SIV) infection in rhesus macaques. This is associated with a pro-inflammatory and oxidative milieu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b317e8a3cef62601270979e1daf2907
https://pubmed.ncbi.nlm.nih.gov/25421506

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