Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Paul Belmonte"'
Autor:
David J. Friedman, Monika Kizerwetter, Paul Belmonte, Matthew Rajcula, Keith Theodore, Hyun Se Kim Lee, Michael J. Shapiro, Haidong Dong, Virginia Smith Shapiro
Publikováno v:
The Journal of Immunology. 208:1845-1850
Inhibitory receptors have a critical role in the regulation of immunity. Siglecs are a family of primarily inhibitory receptors expressed by immune cells that recognize specific sialic acid modifications on cell surface glycans. Many tumors have incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::804592450ef1595bd2c2ff048786be02
https://doi.org/10.4049/jimmunol.2101165
https://doi.org/10.4049/jimmunol.2101165
Autor:
Justin Choe, Paul Belmonte, Matthew Rajcula, Keith Theodore, Hyun Se Kim Lee, Michael J Shapiro, Virginia Shapiro
Publikováno v:
The Journal of Immunology. 208:174.09-174.09
In this study, we harnessed immunomodulatory Siglec-sialic acid interactions to mitigate autoimmune rejection of beta cells in Type 1 Diabetes (T1D). Mice engineered to express the sialyltransferase ST8Sia6 in beta cells (βST mice) were backcrossed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f2d5e54b8799e5dbed5e34097a21f16
https://doi.org/10.4049/jimmunol.208.supp.174.09
https://doi.org/10.4049/jimmunol.208.supp.174.09
Autor:
Justin Choe, Paul Belmonte, Matthew Rajcula, Shaylene McCue, Michael J Shapiro, Virginia Shapiro
Publikováno v:
The Journal of Immunology. 206:18.12-18.12
Cell surface hypersialylation is used by malignant cells as a survival mechanism, leveraging interactions with inhibitory Siglec receptors to dampen immune rejection. In this study, we harnessed this mechanism to prevent autoimmune rejection of beta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::472ccfc9d91e9c14bc6b313c270202c7
https://doi.org/10.4049/jimmunol.206.supp.18.12
https://doi.org/10.4049/jimmunol.206.supp.18.12
Publikováno v:
The Journal of Immunology. 202:68.16-68.16
Type 1 diabetes is an autoimmune disease that destroys insulin-producing beta cells in the pancreatic islets. Although exogenous insulin replacement therapy is lifesaving, precise blood glucose management remains a significant challenge. Experimental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecf009dbadfbc282a0ec9f509827123a
https://doi.org/10.4049/jimmunol.202.supp.68.16
https://doi.org/10.4049/jimmunol.202.supp.68.16
Autor:
Paul Belmonte, Fan-Chi Hsu, Barsha Dash, Ji Young Chung, Sinibaldo Romero Arocha, Virginia Shapiro
Publikováno v:
The Journal of Immunology. 198:60.17-60.17
T cells require additional developmental steps after positive selection before they are functionally competent and can enter the long-lived peripheral T cell pool. During maturation, T cells gain the ability to produce cytokines upon stimulation, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2c5ea9c239514980e071198286837ec
https://doi.org/10.4049/jimmunol.198.supp.60.17
https://doi.org/10.4049/jimmunol.198.supp.60.17
Autor:
Rachael Philips, Meibo Chen, Doug McWilliams, Paul Belmonte, Megan Constans, Scott Hiebert, Virginia Shapiro
Publikováno v:
The Journal of Immunology. 194:51.6-51.6
In order to generate functional peripheral T cells, proper gene regulation during T cell development is critical. Development involves both the activation and repression of genes as cells progress through each developmental checkpoint. Histone acetyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02a3befad1a141847afeef1da23dc898
https://doi.org/10.4049/jimmunol.194.supp.51.6
https://doi.org/10.4049/jimmunol.194.supp.51.6
Autor:
Barsha Dash, Fan-Chi Hsu, Paul Belmonte, Megan Constans, Meibo Chen, Douglas McWilliams, Virginia Shapiro
Publikováno v:
The Journal of Immunology. 194:51.16-51.16
T cell development depends on coordinated gene expression changes in order to progress through developmental checkpoints. The loss of transcription factor Runx1 in CD4-cre Runx1 conditional knockout (cKO) mice leads to decreased numbers of CD4 single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::268921caba82fdb92ad38011ea8352dc
https://doi.org/10.4049/jimmunol.194.supp.51.16
https://doi.org/10.4049/jimmunol.194.supp.51.16
Autor:
Puspa Thapa, Meibo Chen, Doug McWilliams, Paul Belmonte, Megan Constans, Scott Hiebert, Derek Sant'Angelo, Virginia Shapiro
Publikováno v:
The Journal of Immunology. 194:62.19-62.19
iNKT cells differentiate into functional subsets defined as NKT1, NKT2 and NKT17, characterized by their expression of transcription factors, T-bet, GATA3 and ROR-γt and production of IFN-γ, IL-4 and IL-17, respectively. In our earlier studies, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8df3d1b169fb6429b7bf9012e9e61c4d
https://doi.org/10.4049/jimmunol.194.supp.62.19
https://doi.org/10.4049/jimmunol.194.supp.62.19
Autor:
Fan-Chi Hsu, Paul Belmonte, Megan Constans, Meibo Chen, Doug McWilliams, Scott Hiebert, Virginia Shapiro
Publikováno v:
The Journal of Immunology. 194:51.8-51.8
Recent thymic emigrants (RTEs) are newly generated T cells that need to undergo post-thymic maturation in the periphery. The mechanism of T cell maturation remains unclear. Histone deacetylase 3 (HDAC3) controls gene regulation, chromatin accessibili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0508764d242be7b43d4523ff881861a5
https://doi.org/10.4049/jimmunol.194.supp.51.8
https://doi.org/10.4049/jimmunol.194.supp.51.8