Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Paul Begovatz"'
Autor:
Sarah Erickson-Bhatt, Benjamin L. Cox, Erin Macdonald, Jenu V. Chacko, Paul Begovatz, Patricia J. Keely, Suzanne M. Ponik, Kevin W. Eliceiri, Sean B. Fain
Publikováno v:
Metabolites, Vol 14, Iss 10, p 550 (2024)
Background/Objectives: Despite the role of metabolism in breast cancer metastasis, we still cannot predict which breast tumors will progress to distal metastatic lesions or remain dormant. This work uses metabolic imaging to study breast cancer cell
Externí odkaz:
https://doaj.org/article/4526dfd8a73642b4a97de329406cfe57
Autor:
Erin B. Macdonald, Paul Begovatz, Gregory P. Barton, Sarah Erickson-Bhatt, David R. Inman, Benjamin L. Cox, Kevin W. Eliceiri, Roberta M. Strigel, Suzanne M. Ponik, Sean B. Fain
Publikováno v:
Metabolites, Vol 11, Iss 5, p 274 (2021)
This study uses dynamic hyperpolarized [1-13C]pyruvate magnetic resonance spectroscopic imaging (MRSI) to estimate differences in glycolytic metabolism between highly metastatic (4T1, n = 7) and metastatically dormant (4T07, n = 7) murine breast canc
Externí odkaz:
https://doaj.org/article/0e5901338ece4ce1a49ae64e5a7b8b76
Autor:
Sarah Erickson-Bhatt, Roberta M. Strigel, Suzanne M. Ponik, David R. Inman, Gregory P. Barton, Erin B. Macdonald, Benjamin L. Cox, Kevin W. Eliceiri, Sean B. Fain, Paul Begovatz
Publikováno v:
Metabolites
Volume 11
Issue 5
Metabolites, Vol 11, Iss 274, p 274 (2021)
Volume 11
Issue 5
Metabolites, Vol 11, Iss 274, p 274 (2021)
This study uses dynamic hyperpolarized [1-13C]pyruvate magnetic resonance spectroscopic imaging (MRSI) to estimate differences in glycolytic metabolism between highly metastatic (4T1, n = 7) and metastatically dormant (4T07, n = 7) murine breast canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe832e44060ecba56d635bcbcb97574
Autor:
Sofiya Gancheva, Gert Schaart, Michael Roden, Paul Begovatz, Matthijs K. C. Hesselink, Esther Kornips, Esther Phielix, Patrick Schrauwen, Alessandra Bierwagen
Publikováno v:
JCI INSIGHT, 4(21):127928. American Society for Clinical Investigation
BACKGROUND: Insulin resistance results from impaired skeletal muscle glucose transport/phosphorylation, linked to augmented lipid availability. Despite greater intramuscular lipids, athletes are highly insulin sensitive, which could result from highe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9395e3889c4f68ad4ac5b1ba34bb3eb2
https://doi.org/10.1172/jci.insight.127928
https://doi.org/10.1172/jci.insight.127928
Autor:
Paul Begovatz, Peter Nowotny, Chrysi Koliaki, Alessandra Bierwagen, Jesper Lundbom, Daniel F. Markgraf, Birgit Klüppelholz, Bettina Nowotny, Michael Roden, Guido Giani
Publikováno v:
NMR in Biomedicine. 28:898-905
High field MR scanners can resolve a metabolite resonating at 2.06 ppm in the in vivo proton-decoupled liver 31P MR spectrum. Traditionally this peak has been assigned to phosphoenolpyruvate (PEP), the key metabolite for gluconeogenesis. However, rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71a552eae9bf75c6a8cfff9301b004df
https://doi.org/10.1002/nbm.3323
https://doi.org/10.1002/nbm.3323
Autor:
Jürgen Bunke, Bettina Nowotny, Klaus Strassburger, Katharina S. Weber, Chrysi Koliaki, Michael Roden, Peter Nowotny, Karsten Müssig, Giovanni Pacini, J Szendrödi, Paul Begovatz
Publikováno v:
Diabetologia. 58:1646-1655
This study aimed to perform a comprehensive analysis of interlobular, intralobular and parenchymal pancreatic fat in order to assess their respective effects on beta cell function.Fifty-six participants (normal glucose tolerance [NGT] (n = 28), impai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6724bd9beefbac7d12e8429c3228d01
https://doi.org/10.1007/s00125-015-3544-5
https://doi.org/10.1007/s00125-015-3544-5
Autor:
Paul Begovatz, Filipa Carvalho, Christian Herder, Michael Roden, Anett Seelig, Martin Irmler, Cristina Barosa, Sabine Kahl, Johannes Beckers, Peter Nowotny, Bettina Nowotny, Elisa Álvarez Hernández, Yuliya Kupriyanova, Susanne Neschen, Martin Hrabě de Angelis, Jan Rozman, John G. Jones
Publikováno v:
J. Clin. Invest. 127, 695-708 (2017)
BACKGROUND. Dietary intake of saturated fat is a likely contributor to nonalcoholic fatty liver disease (NAFLD) and insulin resistance, but the mechanisms that initiate these abnormalities in humans remain unclear. We examined the effects of a single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a20501d43bf1baef18397209f01e7cd7
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=50426
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=50426
Autor:
Jong-Hee Hwang, Paul Begovatz, Sabine Kahl, Jürgen Bunke, Michael Roden, Klaus Straßburger, Roshan S Livingstone, Guido Giani, Bettina Nowotny
Publikováno v:
Magnetic Resonance Materials in Physics, Biology and Medicine. 27:397-405
Hepatic and pancreatic fat content become increasingly important for phenotyping of individuals with metabolic diseases. This study aimed to (1) evaluate hepatic fat fractions (HFF) and pancreatic fat fractions (PFF) using (1)H magnetic resonance spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39674bda8441494d99db840484c9454c
https://doi.org/10.1007/s10334-013-0421-4
https://doi.org/10.1007/s10334-013-0421-4
Autor:
Jesper Lundbom, Peter Nowotny, Paul Begovatz, Julia Szendroedi, Guido Giani, Kirti Kaul, Klaus Strassburger, Sabine Kahl, Michael Roden, Alessandra Bierwagen, Sofiya Gancheva, Christian Herder, Birgit Knebel, Birgit Klueppelholz, Hadi Al-Hasani
Publikováno v:
Diabetes. 65(7)
Type 1 diabetes has been recently linked to nonalcoholic fatty liver disease (NAFLD), which is known to associate with insulin resistance, obesity, and type 2 diabetes. However, the role of insulin resistance and hyperglycemia for hepatic energy meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d49647a8a4d958c3b0f3ecc560dd30b
https://pubmed.ncbi.nlm.nih.gov/27207512
https://pubmed.ncbi.nlm.nih.gov/27207512
Autor:
Kai Schommer, Paul Begovatz, Peter Bachert, Armin M. Nagel, Stefan H. Hoffmann, Michael Bock, Reiner Umathum
Publikováno v:
Magnetic Resonance in Medicine. 66:1109-1115
An efficient breathing system was designed for direct 17O MRI to perform oxygen metabolism studies of the human brain. The breathing system consists of a demand oxygen delivery device for 17O2 supply and a custom-built re-breathing circuit with pneum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::075663631a3012513fe987f4cec354b3
https://doi.org/10.1002/mrm.22871
https://doi.org/10.1002/mrm.22871