Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Paul Begley"'
Autor:
Sarah Kassab, Paul Begley, Stephanie J. Church, Sanziana M. Rotariu, Cleo Chevalier-Riffard, Andrew W. Dowsey, Alexander M. Phillips, Leo A.H. Zeef, Ben Grayson, Joanna C. Neill, Garth J.S. Cooper, Richard D. Unwin, Natalie J. Gardiner
Publikováno v:
Molecular Metabolism, Vol 28, Iss , Pp 107-119 (2019)
Objective: The impact of diabetes mellitus on the central nervous system is less widely studied than in the peripheral nervous system, but there is increasing evidence that it elevates the risk of developing cognitive deficits. The aim of this study
Externí odkaz:
https://doaj.org/article/5729f0504db341cd97c70ad009936b48
Autor:
Stefano Patassini, Paul Begley, Jingshu Xu, Stephanie J. Church, Nina Kureishy, Suzanne J. Reid, Henry J. Waldvogel, Richard L. M. Faull, Russell G. Snell, Richard D. Unwin, Garth J. S. Cooper
Publikováno v:
Metabolites, Vol 9, Iss 6, p 113 (2019)
Huntington’s disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat in exon 1 of the HTT gene. HD usually manifests in mid-life with loss of GABAergic projection neurons from the striatum accompanied by progressive atrophy of
Externí odkaz:
https://doaj.org/article/14ecf4db38ce4f1f8867a6780060e37d
Autor:
Paul Begley, Pauline Leonard
Values and ethics have traditionally been considered an important influence on administrative practices, and are typically included as a component of core courses in department of educational administration in the US, Canada and Australia. The recent
Autor:
Paul Begley
A riveting account of current events as foretold in the mysterious Book of Revelation.A series of unparalleled apocalyptic events—predicted in a third of the Bible—is approaching. They will so shake the world that people's hearts fail them for
Autor:
Sanziana M. Rotariu, Ben Grayson, Natalie J. Gardiner, Cleo Chevalier-Riffard, Alexander M. Phillips, Richard D. Unwin, Joanna C. Neill, Stephanie J. Church, Andrew W. Dowsey, Paul Begley, Garth J. S. Cooper, Leo A. H. Zeef, Sarah Kassab
Publikováno v:
Kassab, S, Begley, P, Church, S J, Rotariu, S M, Chevalier-riffard, C, Dowsey, A W, Phillips, A M, Zeef, L A H, Grayson, B, Neill, J C, Cooper, G J S, Unwin, R D & Gardiner, N J 2019, ' Cognitive dysfunction in diabetic rats is prevented by pyridoxamine treatment. A multidisciplinary investigation ', Molecular Metabolism, vol. 28, pp. 107-119 . https://doi.org/10.1016/j.molmet.2019.08.003
Molecular Metabolism
Molecular Metabolism, Vol 28, Iss, Pp 107-119 (2019)
Kassab, S, Begley, P, Church, S J, Rotariu, S M, Chevalier-Riffard, C, Dowsey, A W, Phillips, A M, Zeef, L A H, Grayson, B, Neill, J C, Cooper, G J S, Unwin, R D & Gardiner, N J 2019, ' Cognitive dysfunction in diabetic rats is prevented by pyridoxamine treatment : A multidisciplinary investigation ', Molecular metabolism, vol. 28, pp. 107-119 . https://doi.org/10.1016/j.molmet.2019.08.003
Molecular Metabolism
Molecular Metabolism, Vol 28, Iss, Pp 107-119 (2019)
Kassab, S, Begley, P, Church, S J, Rotariu, S M, Chevalier-Riffard, C, Dowsey, A W, Phillips, A M, Zeef, L A H, Grayson, B, Neill, J C, Cooper, G J S, Unwin, R D & Gardiner, N J 2019, ' Cognitive dysfunction in diabetic rats is prevented by pyridoxamine treatment : A multidisciplinary investigation ', Molecular metabolism, vol. 28, pp. 107-119 . https://doi.org/10.1016/j.molmet.2019.08.003
Objective The impact of diabetes mellitus on the central nervous system is less widely studied than in the peripheral nervous system, but there is increasing evidence that it elevates the risk of developing cognitive deficits. The aim of this study w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db998fc89cd30639add1bd650050b734
https://doi.org/10.1016/j.molmet.2019.08.003
https://doi.org/10.1016/j.molmet.2019.08.003
Autor:
Richard L.M. Faull, Garth J. S. Cooper, Stephanie J. Church, Henry J. Waldvogel, Stefano Patassini, Paul Begley, Suzanne J. Reid, Jingshu Xu, Richard D. Unwin, Nina Kureishy, Russell G. Snell
Publikováno v:
Metabolites, Vol 9, Iss 6, p 113 (2019)
Patassini, S, Begley, P, Xu, J, Church, S, Kureishy, N, Reid, S J, Waldvogel, H J, Faull, R L M, Snell, R G, Unwin, R & Cooper, G JS 2019, ' Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington’s Disease ', Metabolites . https://doi.org/10.3390/metabo9060113
Metabolites
Volume 9
Issue 6
Patassini, S, Begley, P, Xu, J, Church, S, Kureishy, N, Reid, S J, Waldvogel, H J, Faull, R L M, Snell, R G, Unwin, R & Cooper, G JS 2019, ' Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington’s Disease ', Metabolites . https://doi.org/10.3390/metabo9060113
Metabolites
Volume 9
Issue 6
Huntington&rsquo
s disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat in exon 1 of the HTT gene. HD usually manifests in mid-life with loss of GABAergic projection neurons from the striatum accompanied by progressive a
s disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat in exon 1 of the HTT gene. HD usually manifests in mid-life with loss of GABAergic projection neurons from the striatum accompanied by progressive a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8102eef15f8428eb957e41ea5cd938
https://www.mdpi.com/2218-1989/9/6/113
https://www.mdpi.com/2218-1989/9/6/113
Autor:
Richard L.M. Faull, Garth J. S. Cooper, Mike Dragunow, Richard D. Unwin, Stephanie J. Church, Russell G. Snell, Suzanne J. Reid, Stefano Patassini, Maurice A. Curtis, Paul Begley, Henry J. Waldvogel, Eric H. Kim, Jingshu Xu
Publikováno v:
Patassini, S, Begley, P, Xu, J, Church, S, Reid, S J, Kim, E H, Curtis, M A, Dragunow, M, Waldvogel, H J, Snell, R G, Unwin, R, Faull, R L M & Cooper, G 2016, ' Metabolite mapping reveals severe widespread perturbation of multiple metabolic processes in Huntington’s disease human brain ', Biochimica et Biophysica Acta-Molecular Basis of Disease, vol. 1862, no. 9, pp. 1650-1662 . https://doi.org/10.1016/j.bbadis.2016.06.002
Huntington's disease (HD) is a genetically-mediated neurodegenerative disorder wherein the aetiological defect is a mutation in the Huntington's gene (HTT), which alters the structure of the huntingtin protein (Htt) through lengthening of its polyglu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d790f5a42a73f87aa18b7a5c77f8f3
Publikováno v:
Eye. 30:773-783
Metabolomics is the study of endogenous and exogenous metabolites in biological systems, which aims to provide comparative semi-quantitative information about all metabolites in the system. Metabolomics is an emerging and potentially powerful tool in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a91c467eefc47f72c4112b2e75d13e
https://doi.org/10.1038/eye.2016.37
https://doi.org/10.1038/eye.2016.37
Autor:
Stephanie J. Church, Jingshu Xu, Richard D. Unwin, Nigel M. Hooper, Katherine A. B. Kellett, Paul Begley, Garth J. S. Cooper, Stefano Patassini, Emma R L C Vardy
Publikováno v:
Xu, J, Church, S J, Patassini, S, Begley, P, Kellett, K A B, Vardy, E R L C, Unwin, R D, Hooper, N M & Cooper, G J S 2018, ' Plasma metals as potential biomarkers in dementia : a case–control study in patients with sporadic Alzheimer’s disease ', BioMetals, vol. 31, no. 2, pp. 267-276 . https://doi.org/10.1007/s10534-018-0089-3
Sporadic Alzheimer's disease (AD) is a neurodegenerative disorder that causes the most prevalent form of age-related dementia but its pathogenesis remains obscure. Altered regulation of metals, particularly pan-cerebral copper deficiency, and more re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e93b1b860e85869d30f5fcb97f02e6b
http://www.scopus.com/inward/record.url?scp=85042928745&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85042928745&partnerID=8YFLogxK
Autor:
Melissa Westwood, Alexander E. P. Heazell, Paul Begley, Charlotte Hulme, Katherine A. Hollywood, Warwick B. Dunn, Adam Stevens, Jenny Myers
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Hulme, C, Stevens, F, Dunn, W, Heazell, A, Hollywood, K, Begley, P, Westwood, M & Myers, J 2018, ' Identification of the functional pathways altered by placental cell exposure to high glucose: lessons from the transcript and metabolite interactome ', Scientific Reports . https://doi.org/10.1038/s41598-018-22535-y
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Hulme, C, Stevens, F, Dunn, W, Heazell, A, Hollywood, K, Begley, P, Westwood, M & Myers, J 2018, ' Identification of the functional pathways altered by placental cell exposure to high glucose: lessons from the transcript and metabolite interactome ', Scientific Reports . https://doi.org/10.1038/s41598-018-22535-y
The specific consequences of hyperglycaemia on placental metabolism and function are incompletely understood but likely contribute to poor pregnancy outcomes associated with diabetes mellitus (DM). This study aimed to identify the functional biochemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e772e45f72c989f0233a263d729fbbb
http://europepmc.org/articles/PMC5869594
http://europepmc.org/articles/PMC5869594