Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Paul B. Mullan"'
Autor:
James P. Beirne, Alan Gilmore, Caitríona E. McInerney, Aideen Roddy, W. Glenn McCluggage, Ian J.G. Harley, M. Abdullah Alvi, Kevin M. Prise, Darragh G. McArt, Paul B. Mullan
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 3359-3371 (2022)
Introduction: Cancers presenting at advanced stages inherently have poor prognosis. High grade serous carcinoma (HGSC) is the most common and aggressive form of tubo-ovarian cancer. Clinical tests to accurately diagnose and monitor this condition are
Externí odkaz:
https://doaj.org/article/1c8bf9d25c064531ac26941f78c36845
Autor:
Paul B. Mullan, Victoria Bingham, Paula Haddock, Gareth W. Irwin, Elaine Kay, Stephen McQuaid, Niamh E. Buckley
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-13 (2019)
Abstract Background Triple Negative breast cancer (TNBC) is a poor outcome subgroup of breast cancer defined based on the absence of expression of ERα and PR and HER2 amplification. These hard to treat cancers lack targeted treatment options and are
Externí odkaz:
https://doaj.org/article/4531eab64b0f409585612c4bdac7b40f
Autor:
Catherine Knowlson, Paula Haddock, Victoria Bingham, Stephen McQuaid, Paul B. Mullan, Niamh E. Buckley
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 12 (2020)
Background: Triple negative breast cancer (TNBC) is the subset of breast cancer associated with the poorest outcome, and currently lacks targeted treatments. Standard of care (SoC) chemotherapy often consists of DNA damaging chemotherapies ± taxanes
Externí odkaz:
https://doaj.org/article/ab780ea7438942eeac9c9a303770bbce
Autor:
Charles M. Haughey, Debayan Mukherjee, Rebecca E. Steele, Amy Popple, Lara Dura-Perez, Adam Pickard, Mehjabin Patel, Suneil Jain, Paul B. Mullan, Rich Williams, Pedro Oliveira, Niamh E. Buckley, Jamie Honeychurch, Simon S. McDade, Timothy Illidge, Ian G. Mills, Sharon L. Eddie
Publikováno v:
Cancers, Vol 12, Iss 10, p 2804 (2020)
The prostate cancer (PCa) field lacks clinically relevant, syngeneic mouse models which retain the tumour microenvironment observed in PCa patients. This study establishes a cell line from prostate tumour tissue derived from the Pten−/−/trp53−/
Externí odkaz:
https://doaj.org/article/2c9282bbbde1491f89dc9d0d4badd84e
Autor:
Paul B. Mullan, D. Paul Harkin, Richard D. Kennedy, Patrick G. Johnston, Dennis J. McCance, Ching-Wei Wang, Simon S. Mc Dade, Katherine Sheehan, Anthony O'Grady, Nyree T. Crawford, Elaine W. Kay, Karin Jirstrom, Susan J. Conlon, Niamh E. Buckley
Supplementary Tables 1-2 from The ΔNp63 Proteins Are Key Allies of BRCA1 in the Prevention of Basal-Like Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44cd2b2740a543844e6fb2e4fbcf1371
https://doi.org/10.1158/0008-5472.22391339.v1
https://doi.org/10.1158/0008-5472.22391339.v1
Autor:
D. Paul Harkin, Peter H. Watson, Patrick G. Johnston, George Reid, Paul B. Mullan, Patrick J. Morrison, Tong F. Lioe, Ethan D. Emberley, Karl Mulligan, Stephen Moore, Colin R. James, Gail E. Stewart, Jennifer E. Quinn, Julia J. Gorski, Richard D. Kennedy
Supplementary Data from BRCA1 and c-Myc Associate to Transcriptionally Repress Psoriasin, a DNA Damage–Inducible Gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71294171ef069218458768d924db819f
https://doi.org/10.1158/0008-5472.22364252
https://doi.org/10.1158/0008-5472.22364252
Autor:
Paul B. Mullan, D. Paul Harkin, Richard D. Kennedy, Patrick G. Johnston, Dennis J. McCance, Ching-Wei Wang, Simon S. Mc Dade, Katherine Sheehan, Anthony O'Grady, Nyree T. Crawford, Elaine W. Kay, Karin Jirstrom, Susan J. Conlon, Niamh E. Buckley
Little is known about the origin of basal-like breast cancers, an aggressive disease that is highly similar to BRCA1-mutant breast cancers. p63 family proteins that are structurally related to the p53 suppressor protein are known to function in stem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eed02e8101f6feafe79e2b9647eee926
https://doi.org/10.1158/0008-5472.c.6503234.v1
https://doi.org/10.1158/0008-5472.c.6503234.v1
Autor:
Paul B. Mullan, D. Paul Harkin, Richard D. Kennedy, Patrick G. Johnston, Dennis J. McCance, Ching-Wei Wang, Simon S. Mc Dade, Katherine Sheehan, Anthony O'Grady, Nyree T. Crawford, Elaine W. Kay, Karin Jirstrom, Susan J. Conlon, Niamh E. Buckley
Supplementary Methods from The ΔNp63 Proteins Are Key Allies of BRCA1 in the Prevention of Basal-Like Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b8eacfc71402ac170a4933a93fc00f
https://doi.org/10.1158/0008-5472.22391342.v1
https://doi.org/10.1158/0008-5472.22391342.v1
Autor:
D. Paul Harkin, Peter H. Watson, Patrick G. Johnston, George Reid, Paul B. Mullan, Patrick J. Morrison, Tong F. Lioe, Ethan D. Emberley, Karl Mulligan, Stephen Moore, Colin R. James, Gail E. Stewart, Jennifer E. Quinn, Julia J. Gorski, Richard D. Kennedy
Evidence is accumulating to suggest that some of the diverse functions associated with BRCA1 may relate to its ability to transcriptionally regulate key downstream target genes. Here, we identify S100A7 (psoriasin), S100A8, and S100A9, members of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a366737102b08d549f7e9bda9f06511
https://doi.org/10.1158/0008-5472.c.6494102
https://doi.org/10.1158/0008-5472.c.6494102
Publikováno v:
World Journal of Clinical Oncology
Feeney, L, Harley, I JG, McCluggage, W G, Mullan, P B & Beirne, J P 2020, ' Liquid biopsy in ovarian cancer: Catching the silent killer before it strikes ', World Journal of Clinical Oncology, vol. 11, no. 11, pp. 868-889 . https://doi.org/10.5306/wjco.v11.i11.868
Feeney, L, Harley, I JG, McCluggage, W G, Mullan, P B & Beirne, J P 2020, ' Liquid biopsy in ovarian cancer: Catching the silent killer before it strikes ', World Journal of Clinical Oncology, vol. 11, no. 11, pp. 868-889 . https://doi.org/10.5306/wjco.v11.i11.868
Epithelial ovarian cancer (EOC) is the most lethal gynaecological malignancy in the western world. The majority of women presenting with the disease are asymptomatic and it has been dubbed the "silent killer". To date there is no effective minimally