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pro vyhledávání: '"Paul B. Bernard"'
Publikováno v:
Neurobiology of Disease, Vol 87, Iss , Pp 134-144 (2016)
Neonatal seizures are associated with long term disabilities including epilepsy and cognitive deficits. Using a neonatal seizure rat model that does not develop epilepsy, but develops a phenotype consistent with other models of intellectual disabilit
Externí odkaz:
https://doaj.org/article/3b6f12906b4640fe88ac995b4717a720
Autor:
Paul B. Bernard, Anna M. Castano, Heather O'Leary, Kameron Simpson, Michael D. Browning, Tim A. Benke
Publikováno v:
Neurobiology of Disease, Vol 59, Iss , Pp 1-17 (2013)
Outside of Fragile X syndrome (FXS), the role of Fragile-X Mental Retardation Protein (FMRP) in mediating neuropsychological abnormalities is not clear. FMRP, p70-S6 kinase (S6K) and protein phosphatase 2A (PP2A) are thought to cooperate as a dynamic
Externí odkaz:
https://doaj.org/article/4a059921a781407b98ebd9b84e3fe38e
Autor:
Logan J. Bigelow, Emily K. Pope, Jennifer B. Knight, Jessica E. Rock, Sarah K. MacLeod, Paul B. Bernard
Publikováno v:
Developmental Neuroscience. 44:557-565
Early-life experiences are critical modifiers of development. An important component of early-life experience is the nature of maternal interactions, which can be modified by stress. During rearing, mothers are typically allocated to single-level cag
Publikováno v:
Laboratory animals.
Experimenter familiarization with laboratory rodents through handling prior to experimentation is an important practice in neurobehavioral research and is implicated in stress, study variability, and replicability. Unfortunately, different handling p
Publikováno v:
J Am Assoc Lab Anim Sci
Laboratory rodent housing conditions vary significantly across laboratories and facilities. Variation in housing can be associated with animal stress leading to study variability and the subsequent inability to replicate experimental findings. Optimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b991f31260db6d81e27594f87cc3f40f
https://europepmc.org/articles/PMC8956216/
https://europepmc.org/articles/PMC8956216/
Autor:
Logan J. Bigelow, Catherine Fiset, Jack H.M. Jarvis, Sarah Macleod, Markus Wöhr, Tim A. Benke, Paul B. Bernard
Publikováno v:
Epilepsybehavior : EB. 127
Early-life seizures (ELS) are associated with autism spectrum disorder (ASD); however, due to a lack of effective treatments for ELS, it is not clear whether ELS plays a causal role, potentiates the ASD phenotype, or is the result of a common pathoph
Publikováno v:
Bernard, P B, Ramsay, L A, MacDonald, D S & Tasker, R A 2017, ' Progressive changes in hippocampal cytoarchitecture in a neurodevelopmental rat model of epilepsy : implications for understanding presymptomatic epileptogenesis, predictive diagnosis, and targeted treatments ', The EPMA journal, vol. 8, no. 3, pp. 247-254 . https://doi.org/10.1007/s13167-017-0111-9
Epilepsies affect about 4% of the population and are frequently characterized by a prolonged “silent” period before the onset of spontaneous seizures. Most current animal models of epilepsy either involve acute seizure induction or kindling proto
Publikováno v:
Neurobiology of Disease, Vol 87, Iss, Pp 134-144 (2016)
Neonatal seizures are associated with long term disabilities including epilepsy and cognitive deficits. Using a neonatal seizure rat model that does not develop epilepsy, but develops a phenotype consistent with other models of intellectual disabilit
Autor:
Tim A. Benke, Paul B. Bernard
Publikováno v:
Experimental Neurology. 263:72-78
Children with epilepsy show a high co-morbidity with psychiatric disorders and autism. One of the critical determinants of a child’s behavioral outcome with autism and cognitive dysfunction is the age of onset of seizures. In order to examine wheth
Publikováno v:
Neuropharmacology. 84:1-12
Using the rat model of early life seizures (ELS), which has exaggerated mGluR mediated long-term depression of synaptic strength (mGluR-LTD) in adulthood, we probed the signaling cascades underlying mGluR-LTD induction. Several inhibitors completely