Zobrazeno 1 - 10
of 272
pro vyhledávání: '"Paul B Watkins"'
Developing evidence-based resources for evaluating postgraduate trainees in the biomedical sciences.
Autor:
Jacqueline E McLaughlin, Rebekah L Layton, Paul B Watkins, Robert A Nicholas, Kim L R Brouwer
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0278297 (2022)
Postgraduate trainees elevate the academic strength of institutions by conducting research, promoting innovation, securing grant funding, training undergraduate students, and building alliances. Rigorous and systematic program evaluation can help ens
Externí odkaz:
https://doaj.org/article/406d4b9f66d34db3a70a1f6158406b61
Autor:
Rachel J Church, Shelli J Schomaker, J Scott Eaddy, Germaine G Boucher, John M Kreeger, Jiri Aubrecht, Paul B Watkins
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240562 (2020)
Glutamate dehydrogenase (GLDH) is a liver-specific biomarker of hepatocellular damage currently undergoing qualification as a drug development tool. Since GLDH is located within the mitochondrial matrix, it has been hypothesized that it might also be
Externí odkaz:
https://doaj.org/article/4b07e64a012741b78f47489226cafa94
Autor:
Leah M Norona, Deborah G Nguyen, David A Gerber, Sharon C Presnell, Merrie Mosedale, Paul B Watkins
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0208958 (2019)
Hepatic fibrosis develops from a series of complex interactions among resident and recruited cells making it a challenge to replicate using standard in vitro approaches. While studies have demonstrated the importance of macrophages in fibrogenesis, t
Externí odkaz:
https://doaj.org/article/4a8008400da24e78b5cc0df33c21a915
Autor:
Herbert L Bonkovsky, Huiman X Barnhart, David M Foureau, Nury Steuerwald, William M Lee, Jiezhun Gu, Robert J Fontana, Paul H Hayashi, Naga Chalasani, Victor M Navarro, Joseph Odin, Andrew Stolz, Paul B Watkins, Jose Serrano, US Drug-Induced Liver Injury Network and the Acute Liver Failure Study Group
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212394 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0206389.].
Externí odkaz:
https://doaj.org/article/c3526bba37924bbf8be75f5fee6b4a60
Autor:
Herbert L Bonkovsky, Huiman X Barnhart, David M Foureau, Nury Steuerwald, William M Lee, Jiezhun Gu, Robert J Fontana, Paul J Hayashi, Naga Chalasani, Victor M Navarro, Joseph Odin, Andrew Stolz, Paul B Watkins, Jose Serrano, US Drug-Induced Liver Injury Network and the Acute Liver Failure Study Group
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0206389 (2018)
Changes in levels of cytokines and chemokines have been proposed as possible biomarkers of tissue injury, including liver injury due to drugs. Recently, in acute drug-induced liver injury (DILI), we showed that 19 of 27 immune analytes were different
Externí odkaz:
https://doaj.org/article/2b7e720581cc4865b744d7229e871314
Autor:
Nury M Steuerwald, David M Foureau, H James Norton, Jie Zhou, Judith C Parsons, Naga Chalasani, Robert J Fontana, Paul B Watkins, William M Lee, K Rajender Reddy, Andrew Stolz, Jayant Talwalkar, Timothy Davern, Dhanonjoy Saha, Lauren N Bell, Huiman Barnhart, Jiezhun Gu, Jose Serrano, Herbert L Bonkovsky
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81974 (2013)
Drug-induced liver injury (DILI) is the most common cause of acute liver failure in the United-States. The aim of the study was to describe serum immune profiles associated with acute DILI, to investigate whether there are profiles associated with cl
Externí odkaz:
https://doaj.org/article/d768e5b0af76443280e55dea3cf693f0
Autor:
Paola, Nicoletti, Andrew, Dellinger, Yi Ju, Li, Huiman X, Barnhart, Naga, Chalasani, Robert J, Fontana, Joseph A, Odin, Jose, Serrano, Andrew, Stolz, Amy S, Etheridge, Federico, Innocenti, Olivier, Govaere, Jane I, Grove, Camilla, Stephens, Guruprasad P, Aithal, Raul J, Andrade, Einar S, Bjornsson, Ann K, Daly, M Isabel, Lucena, Paul B, Watkins
Publikováno v:
Gastroenterology. 164:454-466
Drug-induced liver injury (DILI) due to amoxicillin-clavulanate (AC) has been associated with HLA-A*02:01, HLA-DRB1*15:01 and rs2476601, a missense variant in PTPN22. The aim of this study was to identify novel risk factors for AC-DILI and to constru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd78b67a796948bc306b621f764ac98
https://doi.org/10.1053/j.gastro.2022.11.036
https://doi.org/10.1053/j.gastro.2022.11.036
Autor:
Karamarie, Fecho, Anne E, Thessen, Sergio E, Baranzini, Chris, Bizon, Jennifer J, Hadlock, Sui, Huang, Ryan T, Roper, Noel, Southall, Casey, Ta, Paul B, Watkins, Mark D, Williams, Hao, Xu, William, Byrd, Vlado, Dančík, Marc P, Duby, Michel, Dumontier, Gustavo, Glusman, Nomi L, Harris, Eugene W, Hinderer, Greg, Hyde, Adam, Johs, Andrew I, Su, Guangrong, Qin, Qian, Zhu, Tom, Zisk
Publikováno v:
Clinical and translational science, vol 15, iss 8
Clinical, biomedical, and translational science has reached an inflection point in the breadth and diversity of available data and the potential impact of such data to improve human health and well-being. However, the data are often siloed, disorgani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f27c315c2b4a17c406fc15b5ba6221a
https://doi.org/10.1111/cts.13301
https://doi.org/10.1111/cts.13301
Autor:
James J. Beaudoin, Kyunghee Yang, Jeffry Adiwidjaja, Guncha Taneja, Paul B. Watkins, Scott Q. Siler, Brett A. Howell, Jeffrey L. Woodhead
Publikováno v:
Frontiers in Pharmacology. 13
Inhibition of the canalicular phospholipid floppase multidrug resistance protein 3 (MDR3) has been implicated in cholestatic drug-induced liver injury (DILI), which is clinically characterized by disrupted bile flow and damage to the biliary epitheli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e628b9dad43db10f696df2815e4395b
Autor:
Marc G. Ghany, Paul B. Watkins
Publikováno v:
JAMA. 329:713
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d011a148b8091c6b4f16c3f5b84763a
https://doi.org/10.1001/jama.2023.1002
https://doi.org/10.1001/jama.2023.1002