Výsledky vyhledávání - "Paul B Larkin"

PGE 2 signaling via the neuronal EP2 receptor increases injury in a model of cerebral ischemia

Autor: Katrin I. Andreasson, Xibin Liang, Jing Wang, Rachel K. Lam, Qingkun Liu, William Kong, Tingting Pan, Edward N. Wilson, Mehrdad Shamloo, Qian Wang, Paul B Larkin, Connie Tsai

Publikováno v: Proceedings of the National Academy of Sciences. 116:10019-10024

The inflammatory prostaglandin E2 (PGE(2)) EP2 receptor is a master suppressor of beneficial microglial function, and myeloid EP2 signaling ablation reduces pathology in models of inflammatory neurodegeneration. Here, we investigated the role of PGE(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ede0151089bdf1ba471e511bea2e13
https://doi.org/10.1073/pnas.1818544116

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Chronic Abdominal Pain in IBD Research Initiative: Unraveling Biological Mechanisms and Patient Heterogeneity to Personalize Treatment and Improve Clinical Outcomes

Autor: Paul B Larkin, Caren Heller, Gerard Honig, Sarah Alandra Weaver, Andrés Hurtado-Lorenzo

Publikováno v: Crohn's & Colitis 360. 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c38dcedca5b43571dfde9025431fd5be
https://doi.org/10.1093/crocol/otab034

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Tryptophan 2,3-Dioxygenfase and Indoleamine 2,3-Dioxygenase 1 Make Separate, Tissue-Specific Contributions to Basal and Inflammation-Induced Kynurenine Pathway Metabolism in Mice

Autor: Robert Schwarcz, Hiroshi Funakoshi, Toshikazu Nakamura, Paul J. Muchowski, Francesca M. Notarangelo, Korrapati V. Sathyasaikumar, Paul B. Larkin

Background In mammals, the majority of the essential amino acid tryptophan is degraded via the kynurenine pathway (KP). Several KP metabolites play distinct physiological roles, often linked to immune system functions, and may also be causally involv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728ca577e2b6e5e6486c6b43d7e8b297
https://europepmc.org/articles/PMC5808460/

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Genetic Deficiency of Complement Component 3 does not Alter Disease Progression in a Mouse Model of Huntington's Disease

Autor: Paul B. Larkin, Paul J. Muchowski

Publikováno v: Journal of Huntington's Disease. 1:107-118

Several genes and proteins of the complement cascade are present at elevated levels in brains of patients with Huntington's disease (HD). The complement cascade is well characterized as an effector arm of the immune system, and in the brain it is imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d811f907b69d953378bfcd47f99f80fa
https://doi.org/10.3233/jhd-2012-120021

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Suppression of Alzheimer-associated inflammation by microglial prostaglandin-E2 EP4 receptor signaling

Autor: Ju Shi, Qian Wang, Katrin I. Andreasson, Paul B Larkin, Jenny U. Johansson, Nathaniel S. Woodling, Olivier Boutaud, Irene Zagol-Ikapitte, Prachi Priyam

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(17)

A persistent and nonresolving inflammatory response to accumulating Aβ peptide species is a cardinal feature in the development of Alzheimer's disease (AD). In response to accumulating Aβ peptide species, microglia, the innate immune cells of the b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73233092a3041d7b53fe283588ccac61
https://pubmed.ncbi.nlm.nih.gov/24760848

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