Výsledky vyhledávání - "Paul B Hardy"

Akademický článek

A novel small molecule screening assay using normal human chondrocytes toward osteoarthritis drug discovery.

Autor: Philip R Coryell, Paul B Hardy, Susan Chubinskaya, Kenneth H Pearce, Richard F Loeser

Publikováno v: PLoS ONE, Vol 19, Iss 11, p e0308647 (2024)

Osteoarthritis (OA) is the most common form of arthritis and a leading cause of pain and disability in adults. A central feature is progressive cartilage degradation and matrix fragment formation driven by the excessive production of matrix metallopr

Externí odkaz: https://doaj.org/article/719a3021bfe04691916be59e7dc576e8

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Small molecule screening identifies inhibitors of the Epstein-Barr virus deubiquitinating enzyme, BPLF1

Autor: Sage L. Atkins, Sharon E. Hopcraft, Safiyyah Motaib, Peter Foote, Christopher B. Whitehurst, Blossom Damania, Kenneth H. Pearce, Julia Shackelford, Ashley H. Wade, Paul B. Hardy, Joseph S. Pagano, Laura C. Wiser

Publikováno v: Antiviral Res

Herpesviral deubiquitinating enzymes (DUBs) were discovered in 2005, are highly conserved across the family, and are proving to be increasingly important players in herpesviral infection. EBV's DUB, BPLF1, is known to regulate both cellular and viral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed7a274f82224535df12150c5f7094f3
https://pubmed.ncbi.nlm.nih.gov/31711927

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