Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Paul B Comish"'
Autor:
Paul B Comish, Ana Luiza Drumond, Hazel L Kinnell, Richard A Anderson, Angabin Matin, Marvin L Meistrich, Gunapala Shetty
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93311 (2014)
Exposure to radiation during fetal development induces testicular germ cell tumors (TGCT) and reduces spermatogenesis in mice. However, whether DNA damaging chemotherapeutic agents elicit these effects in mice remains unclear. Among such agents, cycl
Externí odkaz:
https://doaj.org/article/46f27dca5a4e46849f8299f3377c0081
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32064 (2012)
The prevalence of testicular germ cell tumors (TGCT), a common solid tissue malignancy in young men, has been annually increasing at an alarming rate of 3%. Since the majority of testicular cancers are derived from germ cells at the stage of transfor
Externí odkaz:
https://doaj.org/article/40a79151ed0c4f90b30583e0ab64c232
Publikováno v:
Journal of Pancreatology, Vol 4, Iss 2, Pp 76-81 (2021)
Abstract. Pancreatic ductal adenocarcinoma is the main cause of cancer-related mortality, with a lack of effective treatments and overall survival rates far lower than other solid cancers. This clinical challenge is related to late diagnosis as well
Externí odkaz:
https://doaj.org/article/defbc94b055c498c9a0ff8554ff190d5
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis 3.0) recommended defining sepsis as a life-threatening organ dysfunction caused by the host's uncontrolled response to infection. The bromodomain and extra-terminal (BE
Externí odkaz:
https://doaj.org/article/09ae2462c87f46089a2a466f18e68cca
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Sepsis is a potentially life-threatening, pathological condition caused by a dysregulated host response to infection. Pathologically, systemic inflammation can initiate coagulation activation, leading to organ dysfunction, and ultimately to multiple
Externí odkaz:
https://doaj.org/article/5106808fa73e414fa677f243ef69478b
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The induction and consequences of regulated cell death (RCD) are accompanied by changes in gene and protein expression, biochemical pathways, as well as cell morphology and size. Such RCDs have a significant impact on development, tissue homeostasis,
Externí odkaz:
https://doaj.org/article/6c7b95b50e3240219de9ca80708ec343
Publikováno v:
Burns. 48:168-175
Objective Damage associated molecular patterns (DAMPs) are pathological mediators linking local tissue damage to systemic inflammation in various diseases. Some DAMPs, such as mitochondrial DNA (mtDNA), can be recognized by the cytoplasmic cGAS prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6744306cd60157e739bda10b3c9d681
https://doi.org/10.1016/j.burns.2021.04.007
https://doi.org/10.1016/j.burns.2021.04.007
Publikováno v:
Journal of Pancreatology, Vol 4, Iss 2, Pp 76-81 (2021)
Pancreatic ductal adenocarcinoma is the main cause of cancer-related mortality, with a lack of effective treatments and overall survival rates far lower than other solid cancers. This clinical challenge is related to late diagnosis as well as primary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e0b95ce79bea520c865cde41c6b7b0
https://doi.org/10.1097/jp9.0000000000000067
https://doi.org/10.1097/jp9.0000000000000067
Publikováno v:
The Journal of Immunology. 205:1189-1197
Thermal injury is often associated with a proinflammatory state resulting in serious complications. After a burn, the innate immune system is activated with subsequent immune cell infiltration and cytokine production. Although the innate immune respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2965d382e90bb123b2236793d0c23679
https://doi.org/10.4049/jimmunol.2000439
https://doi.org/10.4049/jimmunol.2000439
Publikováno v:
Cancer Gene Therapy. 27:645-656
Ferroptosis, a form of regulated cell death, is characterized by an excessive degree of iron accumulation and lipid peroxidation. Although it was originally identified only in cells expressing a mutant RAS oncogene, ferroptosis has also been found in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016d6563ddd5324d1412190a2f31cb99
https://doi.org/10.1038/s41417-020-0170-2
https://doi.org/10.1038/s41417-020-0170-2