Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration

Autor: Paul Atherfold, Hanna Hailu, Louis Christodoulou, Lena E. D’Hooghe, Bryan Smith, Helene Margaret Finney, Frank R. Brennan, Stevan Shaw, Kerry Louise Tyson, Daniel John Lightwood, Andrea Kiessling, Kevin Greenslade, Omar Qureshi, Lara Kevorkian, Rebecca Munro, Kate L. Dixon, Rocio Lledo-Garcia, Shauna West, Christoph Meier, Matthew C. Catley, Kaushik Sarkar, Alison Turner, Roohi Tewari, Sophie P. Shaw

Publikováno v: mAbs

Rozanolixizumab (UCB7665), a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P), has been developed to reduce pathogenic IgG in autoimmune and alloimmune diseases. We document the antibody isolation and compare

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045641d5108e50151ed33d8046d2ce07
http://europepmc.org/articles/PMC6291300

Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus

Autor: Nicholas W. Wood, Chris C. A. Spencer, Konrad Koss, Heike I. Grabsch, Ananth C. Viswanathan, Simon C. Potter, Thomas L. Vaughan, Brian J. Reid, Céline Bellenguez, Kimberley Howarth, Claire Brooks, Michael Gibbons, Geoffrey Liu, David Ferry, Ian Tomlinson, Chuka U. Nwokolo, John de Caestecker, Barrie Rathbone, Francesco Lescai, Anna Rautanen, Weimin Ye, Nicholas I. Church, Nigel C. Bird, Laura J. Hardie, Peter H. Watson, Ross McManus, Peter Donnelly, David Cunningham, Peter Sasieni, Aiden Corvin, Cisca Wijmenga, Sarah Edkins, Amy Strange, Sheldon C. Cooper, Audrey Duncanson, Harvey A. Risch, Ian Sargeant, Christopher Macdonald, Pradeep Bhandari, Sarah E. Hunt, Matthew D. Rutter, John V. Reynolds, Nigel Trudgill, Rebecca Harrison, Anna H. Wu, Scott Sanders, Christopher G. Mathew, Mark S. Anderson, Raf Bisschops, Cathryn Edwards, Avazeh Tashakkori-Ghanbaria, Praful Patel, Wong Ho Chow, Anouk Van Der Winkel, Panos Deloukas, Kishor Vaidya, Manoj Nanji, Nichola L. Gellatly, Leena Peltonen, Iain A. Murray, Matthew A. Brown, Deborah Glancy, Marilie D. Gammon, Robert Plomin, Julie Hapeshi, Elia Stupka, Janusz Jankowski, Liam J. Murray, Alan G. Casson, Hugh McMurtry, Haythem Ali, Douglas A. Corley, Kausila Krishnadath, Hugh Barr, David Johnston, Derek Alderson, Ruth E Langley, Elvira Bramon, Saj Wajed, Sharon Love, Peter D. Siersema, Ernst J. Kuipers, Simon Panter, Mark R. Middleton, Ian D. Penman, Peter Isaacs, Krish Ragunath, David K. Levine, Paul Atherfold, Maikel P. Peppelenbosch, Joost P.H. Drenth, Claire Palles, Art Tucker, Stephen Attwood, Cordelia Langford, Rui Zhang, Matti Pirinen, Colin Freeman, Stephen Sawcer, Stuart MacGregor, Hugh S. Markus, S Paterson, Anna M. Nicholson, M Griffin, Nicola Burch, Colin Rodgers, Helen Winter, Anjan Dhar, Zhan Su, Emma Gray, Jantine W. P. M. van Baal, Richard C. Trembath, David Monk, Paul Mullins, Danielle Morris, Ashref Tawil, Serge Dronov, Hans Prenen, Yeng Ang, Dermot Kelleher, Gavin Band, Leslie Bernstein, Weronica E. Ek, H Smart, Luc J. W. van der Laan, Colin N. A. Palmer, Jenefer M. Blackwell, Wilbert H.M. Peters, David C. Whiteman, Tore Lind, Gosia Trynka, Helen Dallal, Paul Moayyedi, Russell D. Petty, Richard S. Gillies, Nicholas J. Shaheen, Chris Haigh, Sue Cullen, Gareth E. Davies, Julia Brown, Jean-Baptiste Cazier, Juan P. Casas, Yvonne Romero

Publikováno v: Nature Genetics, 44, 1131-6
Nature genetics
Nature Genetics, 44, 10, pp. 1131-6
Nature genetics, 44(10), 1131-+. Nature Publishing Group
Su, Z, Gay, L J, Strange, A, Palles, C, Band, G, Whiteman, D C, Lescai, F, Langford, C, Nanji, M, Edkins, S, van der Winkel, A, Levine, D, Sasieni, P, Bellenguez, C, Howarth, K, Freeman, C, Trudgill, N, Tucker, A T, Pirinen, M, Peppelenbosch, M P, van der Laan, L J W, Kuipers, E J, Drenth, J P H, Peters, W H, Reynolds, J V, Kelleher, D P, McManus, R, Grabsch, H, Prenen, H, Bisschops, R, Krishnadath, K, Siersema, P D, van Baal, J W P M, Middleton, M, Petty, R, Gillies, R, Burch, N, Bhandari, P, Paterson, S, Edwards, C, Penman, I, Vaidya, K, Ang, Y, Murray, I, Patel, P, Ye, W, Mullins, P, Wu, A H, Bird, N C, Lind, T & Esophageal Adenocarcinoma Genetics Consortium 2012, ' Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus ', Nature Genetics, vol. 44, no. 10, pp. 1131-6 . https://doi.org/10.1038/ng.2408
Nature Genetics, 44(10), 1131-+. Nature Publishing Group

Barrett's esophagus is an increasingly common disease that is strongly associated with reflux of stomach acid and usually a hiatus hernia, and it strongly predisposes to esophageal adenocarcinoma (EAC), a tumor with a very poor prognosis. We report t

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http://ora.ox.ac.uk/objects/uuid:89f39572-3941-4dbb-b208-14af73dbc475

M1969 Expression of Hypoxia Inducible Factor 1α (HIF-1α) in the Progression to Oesophageal Adenocarcinoma: A Key Target for Therapy

Autor: Naoki Teratani, Paul Atherfold, Janusz Jankowski, Anita Milicic, Anna M. Nicholson

Publikováno v: Gastroenterology. 134:A-441

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::177bde65f92d5c3f9ad738c64abb4f81
https://doi.org/10.1016/s0016-5085(08)62062-4