Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Paul Anthony Keedwell"'
Autor:
Alexander D Shaw, Krish D. Singh, Paul Anthony Keedwell, Jennifer Brealy, Heather N. Richardson, Suresh D. Muthukumaraswamy
Publikováno v:
Psychological Medicine. 45:783-794
Background.Electroencephalography and magnetoencephalography (MEG) studies have identified alterations in gamma-band (30–80 Hz) cortical activity in schizophrenia and mood disorders, consistent with neural models of disturbed glutamate (and GABA) n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77fb8cf2267535b3e9110c3cfe18be78
https://doi.org/10.1017/s0033291714001846
https://doi.org/10.1017/s0033291714001846
Autor:
Jennifer Brealy, Krishna D. Singh, Richard A.E. Edden, C. John Evans, Suresh D. Muthukumaraswamy, Heather N. Richardson, Nicolaas A.J. Puts, Alexander D Shaw, Paul Anthony Keedwell
Publikováno v:
Biological Psychiatry. 73:691-698
Background: Magnetic resonance spectroscopy (MRS) studies have consistently demonstrated reduced cortical γ-aminobutyric acid (GABA) concentrations in individuals with major depression. However, evidence for a persistent deficit during remission, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc0570521cd8202077093780d0e9463
https://doi.org/10.1016/j.biopsych.2012.09.032
https://doi.org/10.1016/j.biopsych.2012.09.032
Publikováno v:
Current Opinion in Psychiatry. 26:27-32
Purpose of review: Neuroimaging has become a central technique of biological psychiatry and is uniquely suited to assess functional and structural brain changes in psychiatric patients in vivo. In this review, we highlight several recent developments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da8f961db52764de0dc2f8713523b55
https://doi.org/10.1097/yco.0b013e32835a0b63
https://doi.org/10.1097/yco.0b013e32835a0b63
Autor:
Philip McGuire, Paolo Fusar-Poli, Paul Anthony Keedwell, Lucia Valmaggia, Mary L. Phillips, Isabel Valli, L. Xenaki, Matthew R. Broome, Stefania Tognin, Gemma Modinos, Marianna Frascarelli, James M. Stone, James Woolley, Andrea Mechelli, Paul Allen
Background.The majority of people at ultra high risk (UHR) of psychosis also present with co-morbid affective disorders such as depression or anxiety. The neuroanatomical and clinical impact of UHR co-morbidity is unknown.Method.We investigated group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4bfcc14cda364bb5f9b2ac65fc65ef
https://ora.ox.ac.uk/objects/uuid:ec411cfa-5a00-46aa-8ed3-1fe9f5efa155
https://ora.ox.ac.uk/objects/uuid:ec411cfa-5a00-46aa-8ed3-1fe9f5efa155
Autor:
Paul Anthony Keedwell, D. Drapier, Mick Brammer, Simon Surguladze, Vincent Giampietro, Mary L. Phillips
Publikováno v:
Journal of Affective Disorders
Journal of Affective Disorders, Elsevier, 2010, 120 (1-3), pp.120-5. ⟨10.1016/j.jad.2009.04.031⟩
Journal of Affective Disorders, 2010, 120 (1-3), pp.120-5. ⟨10.1016/j.jad.2009.04.031⟩
Journal of Affective Disorders, Elsevier, 2010, 120 (1-3), pp.120-5. ⟨10.1016/j.jad.2009.04.031⟩
Journal of Affective Disorders, 2010, 120 (1-3), pp.120-5. ⟨10.1016/j.jad.2009.04.031⟩
Background Previous follow-up studies indicate that increased visual cortical, ventral cingulate and subcortical responses of depressed individuals to sad facial stimuli, but not happy stimuli could represent reversible markers of disease severity. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25271ec5fe2396e3ae1c86bb4c0da586
https://doi.org/10.1016/j.jad.2009.04.031
https://doi.org/10.1016/j.jad.2009.04.031
Publikováno v:
Biological Psychiatry. 58:843-853
Background Anhedonia is a relative lack of pleasure in response to formerly rewarding stimuli. It is an important diagnostic feature of major depressive disorder (MDD), and predicts antidepressant efficacy. Understanding its neurobiological basis may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623c7761ff2c812d94e9e71b8919a892
https://doi.org/10.1016/j.biopsych.2005.05.019
https://doi.org/10.1016/j.biopsych.2005.05.019
Publikováno v:
Biological Psychiatry. 58:495-503
BACKGROUND: The ventromedial prefrontal cortex (VMPFC) is a region implicated in the assessment of the rewarding potential of stimuli and may be dysfunctional in major depressive disorder (MDD). The few studies examining prefrontal cortical responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84af71678e61e8eae24909c6b2ac8901
https://doi.org/10.1016/j.biopsych.2005.04.035
https://doi.org/10.1016/j.biopsych.2005.04.035
Publikováno v:
Advances in Psychiatric Treatment. 9:446-455
Three main approaches are used to explore the neural correlates of mood disorder: neuropsychological studies, neuroimaging studies and post-mortem investigations. Lesion studies implicate disturbances in the frontal lobe, basal ganglia, striatum and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f88767536d22f47b0efbb2c935005d65
https://doi.org/10.1192/apt.9.6.446
https://doi.org/10.1192/apt.9.6.446
Autor:
Paul Anthony Keedwell, Allan H. Young
Publikováno v:
Expert opinion on emerging drugs. 19(1)
The acute management of bipolar depression presents particular challenges. In most cases, it responds poorly to traditional antidepressants - chronicity and partial response are commonly observed. In a subset of patients, antidepressants provoke a sw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c09dff276988ca4dc1909e3a0904362
https://pubmed.ncbi.nlm.nih.gov/24397318
https://pubmed.ncbi.nlm.nih.gov/24397318
Autor:
Rosanna Chapman, Paul Anthony Keedwell, Derek K. Jones, John Evans, Kat Christiansen, Heather N. Richardson
Publikováno v:
Biological psychiatry. 72(4)
Background: Altered white matter microstructure in tracts integral to mood regulation networks could underlie vulnerability to major depressive disorder (MDD). Guided by functional magnetic resonance studies, we explored whether a positive family his
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3c11b457de5a91fe26b9c4132545f4
https://pubmed.ncbi.nlm.nih.gov/22386005
https://pubmed.ncbi.nlm.nih.gov/22386005