Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Paul Anthony Adlard"'
Autor:
Simote Totauhelotu Foliaki, Victoria Lewis, Abu Mohammed Taufiqual Islam, Laura Jane Ellett, Matteo Senesi, David Isaac Finkelstein, Blaine Roberts, Victoria A Lawson, Paul Anthony Adlard, Steven John Collins
Publikováno v:
PLoS Pathogens, Vol 15, Iss 4, p e1007712 (2019)
Although considerable evidence supports that misfolded prion protein (PrPSc) is the principal component of "prions", underpinning both transmissibility and neurotoxicity, clear consensus around a number of fundamental aspects of pathogenesis has not
Externí odkaz:
https://doaj.org/article/680806a49af640c999e500a3e009b326
Autor:
Shalini S. Rao, Paul Anthony Adlard
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
There is an emerging link between the accumulation of iron in the brain and abnormal tau pathology in a number of neurodegenerative disorders, such as Alzheimer’s disease (AD). Studies have demonstrated that iron can regulate tau phosphorylation by
Externí odkaz:
https://doaj.org/article/5b6b3572aae24ca7b4a9ca04ad9c52db
Autor:
Suzanne Hosie, Daniel T. Malone, Stephanie Liu, Michelle Glass, Paul Anthony Adlard, Anthony John Hannan, Elisa L. Hill-Yardin
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Understanding neuronal mechanisms underlying aggression in patients with autism spectrum disorder (ASD) could lead to better treatments and prognosis. The Neuroligin-3 (NL3)R451C mouse model of ASD has a heightened aggressive phenotype, however the b
Externí odkaz:
https://doaj.org/article/0d228369304242998842a86166d062eb
Autor:
Simote Totauhelotu Foliaki, Victoria Lewis, David Isaac Finkelstein, Victoria Lawson, Harold Arthur Coleman, Matteo Senesi, Abu Mohammed Taufiqual Islam, Feng Chen, Shannon Sarros, Blaine Roberts, Paul Anthony Adlard, Steven John Collins
Publikováno v:
PLoS Pathogens, Vol 14, Iss 8, p e1007214 (2018)
Although misfolding of normal prion protein (PrPC) into abnormal conformers (PrPSc) is critical for prion disease pathogenesis our current understanding of the underlying molecular pathophysiology is rudimentary. Exploiting an electrophysiology parad
Externí odkaz:
https://doaj.org/article/711678d966744eccba3dfa4eaf8d1291
Autor:
Paul Anthony Adlard, Roger S Chung
Publikováno v:
Frontiers in Aging Neuroscience, Vol 7 (2015)
Externí odkaz:
https://doaj.org/article/7336533d3e3a4629b81de566201b2e19
Publikováno v:
Frontiers in Aging Neuroscience, Vol 6 (2014)
Much of the research in Alzheimer’s disease (AD) that uses mouse models focuses on the early-onset form of the disease, which accounts for less than 5% of cases. In contrast, this study used a late-onset AD model to examine the interaction between
Externí odkaz:
https://doaj.org/article/f8c9e1953dc446e1a053a508da7384c5
Autor:
Paul Anthony Adlard, Ashley Ian Bush
Publikováno v:
Frontiers in Psychiatry, Vol 3 (2012)
As the burden of proof for the role of metal ion dysregulation in the pathogenesis of multiple CNS disorders grows, it has become important to more precisely identify and differentiate the biological effects of various pharmacological modulators of m
Externí odkaz:
https://doaj.org/article/2224588d56e643da94351b84a0c7d7eb