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Abstract 335: c-KIT targeted ETBs for cancer therapy and HSC transplant conditioning

Autor: Caleigh Howard, Shu Wiley, Wenzhao Dong, Andrea Mendiola, Veronica Partridge, Sara LeMar, Paul Amador, Amit K. Chaudhary, Joseph D. Dekker, Jay Zhao, Ross Durland, Aimee Iberg

Publikováno v: Cancer Research. 82:335-335

Engineered toxin bodies (ETBs) are next-generation immunotoxins that harbor an antibody-derived targeting domain and a cytotoxic payload derived from Shiga-like toxin-1 catalytic subunit A (SLTA). SLTA has been engineered to reduce innate immunogenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48bf0f44bbe00d6e794c14f27458ec55
https://doi.org/10.1158/1538-7445.am2022-335

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Optimization of a novel biophysical model using large scale in vivo antisense hybridization data displays improved prediction capabilities of structurally accessible RNA regions

Autor: Jorge Vazquez-Anderson, Lydia M. Contreras, Mia K. Mihailovic, Seung Hee Cho, Katie Haning, Warren B. Powell, Paul Amador, Kevin C. Baldridge, Kristofer G. Reyes

Publikováno v: Nucleic Acids Research

Current approaches to design efficient antisense RNAs (asRNAs) rely primarily on a thermodynamic understanding of RNA–RNA interactions. However, these approaches depend on structure predictions and have limited accuracy, arguably due to overlooking

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c04a9707fed735aaf0b5ab4140bd720
http://europepmc.org/articles/PMC5435917

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A Genome-Wide Search for Ionizing-Radiation-Responsive Elements in Deinococcus radiodurans Reveals a Regulatory Role for the DNA Gyrase Subunit A Gene's 5′ Untranslated Region in the Radiation and Desiccation Response

Autor: Thomas J. Lamkin, Roland Saldanha, Justin Janovsky, Lydia M. Contreras, Jordan K. Villa, Arijit Bhuyan, Paul Amador

Publikováno v: Applied and Environmental Microbiology. 83

Tight regulation of gene expression is important for the survival of Deinococcus radiodurans , a model bacterium of extreme stress resistance. Few studies have examined the use of regulatory RNAs as a possible contributing mechanism to ionizing radia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3c5d612e3b460aee40638721aacfc5
https://doi.org/10.1128/aem.00039-17

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Abstract 2984: Design and characterization of bispecific engineered toxin bodies for targeted cancer therapy

Autor: Steven P. Rivera, Michael Jamaleddine, Erin Willert, Aimee Iberg, Garrett L. Robinson, Caleigh Howard, Garrett L. Cornelison, Paul Amador

Publikováno v: Cancer Research. 79:2984-2984

Engineered Toxin Bodies (ETBs) are a distinct class of targeted immunotoxins in development as anti-cancer therapeutics by Molecular Templates. ETBs drive a potent and targeted response mediated by antibody-like binding, induced internalization, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23a4f972791eeb11edb9f872667cbec2
https://doi.org/10.1158/1538-7445.am2019-2984

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