Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Paul Allegretti"'
Autor:
Mark Smith, Justin P. Annes, Paul Allegretti, Benjamin Yeh, Matthew Caffet, Yassan Abdolazimi, Timothy M. Horton, Hannah P. Moeller, Guillermina Michel
Publikováno v:
Bioorg Med Chem
Small molecule stimulation of β-cell regeneration has emerged as a promising therapeutic strategy for diabetes. Although chemical inhibition of dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) is sufficient to enhance β-cell r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c14bde7a6a312e8cc57343ff6fb1ca
https://pubmed.ncbi.nlm.nih.gov/31757680
https://pubmed.ncbi.nlm.nih.gov/31757680
Publikováno v:
Organic Letters. 18:64-67
A variety of substituted indoles and benzofurans are accessed via a platinum catalyzed annulation and vinylogous addition of enol nucleophiles. Several β-dicarbonyl compounds participate in the reaction, as do α-nitro and α-cyano carbonyl species.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9098c92b41801c44a58ad2596e5219f3
https://doi.org/10.1021/acs.orglett.5b03246
https://doi.org/10.1021/acs.orglett.5b03246
Autor:
Hannah P. Moeller, Justin P. Annes, Mark Smith, Neali A Armstrong, Yassan Abdolazimi, Sooyeon Lee, Timothy M. Horton, Benjamin Yeh, David McCutcheon, Haixia Xu, Robert J. Nichols, Paul Allegretti, Aryaman Shalizi, Zhengshan Zhao
Pharmacologic expansion of endogenous β cells is a promising therapeutic strategy for diabetes. To elucidate the molecular pathways that control β-cell growth we screened ∼2400 bioactive compounds for rat β-cell replication-modulating activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d23618a08522a31d31e5fde9a0b579a
https://europepmc.org/articles/PMC6287593/
https://europepmc.org/articles/PMC6287593/
Publikováno v:
Organic letters. 19(1)
Formal syntheses of tetracyclic terpenoids frondosin B and liphagal are described. Both synthetic routes rely on the use of platinum-catalyzed α,β-unsaturated carbene formation for the key C–C bond forming transformations. The successful route to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f76340b6fb3c646fd7c74469fc614a3
https://pubmed.ncbi.nlm.nih.gov/27997203
https://pubmed.ncbi.nlm.nih.gov/27997203
Autor:
Paul Allegretti, Mark Smith, Justin P. Annes, Hannah P. Moeller, Sooyeon Lee, Timothy M. Horton
Publikováno v:
Cell Chemical Biology. 26:213-222.e6
Summary Diabetes is a hyperglycemic condition characterized by pancreatic β-cell dysfunction and depletion. Whereas methods for monitoring β-cell function in vivo exist, methods to deliver therapeutics to β cells are lacking. We leveraged the rare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8521e602d26d282307860eb83cdf6556
https://doi.org/10.1016/j.chembiol.2018.10.019
https://doi.org/10.1016/j.chembiol.2018.10.019
Autor:
Eric M. Ferreira, Paul Allegretti
Publikováno v:
Chem. Sci.. 4:1053-1058
A novel synthesis of regioisomeric isoxazoles is described. Using catalytic platinum, both propargylic N-hydroxycarbamates and N-alkoxycarbonyl amino ethers can be cyclized to form differentially substituted isoxazoles. Reaction conditions are develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2649d773188cc0305a65e167185fc8c
https://doi.org/10.1039/c2sc21671j
https://doi.org/10.1039/c2sc21671j
Publikováno v:
ChemInform. 47
A variety of substituted indoles and benzofurans are accessed via a platinum catalyzed annulation and vinylogous addition of enol nucleophiles. Several β-dicarbonyl compounds participate in the reaction, as do α-nitro and α-cyano carbonyl species.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5ecd9952f96f2a1059cacf8e6812b15
https://doi.org/10.1002/chin.201621155
https://doi.org/10.1002/chin.201621155
Autor:
Paul Allegretti, Eric M. Ferreira
Publikováno v:
ChemInform. 45
A novel platinum-catalyzed double heterocyclization of propargylic ethers is described. The transformation exploits the intermediacy of a key α,β-unsaturated carbene. The reactivity of this carbene is such that systems can be developed which avoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b408ab1369610680dfabe8cd41c4bc88
https://doi.org/10.1002/chin.201423118
https://doi.org/10.1002/chin.201423118
Autor:
Eric M. Ferreira, Paul Allegretti
Publikováno v:
Journal of the American Chemical Society. 135(46)
A novel platinum-catalyzed double heterocyclization of propargylic ethers is described. The transformation exploits the intermediacy of a key α,β-unsaturated carbene. The reactivity of this carbene is such that systems can be developed which avoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced5c833e0412793e6ab01eb769902e6
https://pubmed.ncbi.nlm.nih.gov/24175883
https://pubmed.ncbi.nlm.nih.gov/24175883
Autor:
Eric M. Ferreira, Paul Allegretti
Publikováno v:
ChemInform. 43
Mono-, bis- and trisubstituted furan derivatives are prepared with high yields from homopropargylic alcohols.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e7782181e2a201b8d9f0d51c1ba5d0d
https://doi.org/10.1002/chin.201212186
https://doi.org/10.1002/chin.201212186