Re-interpreting tumour behaviour and the tumour microenvironment as normal responses to tissue disorganisation

Autor: Edwards, Paul AW

Much of tumour cell biology and the tumour microenvironment may be normal wound healing responses as a consequence of the disruption of tissue structure. This is why tumours resemble wounds, and many features of the tumour microenvironment, such as t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291603c7207ac70d35681caec0dda870

Serial circulating tumor DNA detection using a personalized, tumor-informed assay in esophageal adenocarcinoma patients following resection

Autor: Ococks, Emma, Sharma, Shruti, Ng, Alvin Wei Tian, Consortium, OCCAMS, Aleshin, Alexey, Fitzgerald, Rebecca C, Smyth, Elizabeth, Edwards, Paul AW, Grehan, Nicola, Nutzinger, Barbara, Fidziukiewicz, Elwira, Redmond, Aisling M, Northrop, Alex, Abbas, Sujath, Smyth, Elizabeth C, O���Donovan, Maria, Miremadi, Ahmad, Malhotra, Shalini, Tripathi, Monika, Grantham, Amber, Cheah, Calvin, Coles, Hannah, Flint, Connor, Eldridge, Matthew, Secrier, Maria, Devonshire, Ginny, Jammula, Sriganesh, Davies, Jim, Crichton, Charles, Carroll, Nick, Hardwick, Richard H, Safranek, Peter, Hindmarsh, Andrew, Sujendran, Vijayendran, Hayes, Stephen J, Ang, Yeng, Sharrocks, Andrew, Preston, Shaun R, Bagwan, Izhar, Save, Vicki, Skipworth, Richard JE, Hupp, Ted R, O���Neill, J Robert, Tucker, Olga, Beggs, Andrew, Taniere, Philippe, Puig, Sonia, Contino, Gianmarco, Underwood, Timothy J, Walker, Robert C, Grace, Ben L, Lagergren, Jesper, Gossage, James, Mahadeva, Ula, Davies, Andrew, Chang, Fuju, Goh, Vicky, Ciccarelli, Francesca D, Sanders, Grant, Berrisford, Richard, Chan, David, Cheong, Ed, Kumar, Bhaskar, Sreedharan, L, Parsons, Simon L, Soomro, Irshad, Kaye, Philip, Saunders, John, Lovat, Laurence, Haidry, Rehan, Scott, Michael, Sothi, Sharmila, Lishman, Suzy, Hanna, George B, Moorthy, Krishna, Peters, Christopher J, Grabowska, Anna, Turkington, Richard, McManus, Damian, Coleman, Helen, Petty, Russell D

No description supplied

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d48271b240cdf50573d8e0a2f9f843

CHD1L Regulates Cell Survival in Breast Cancer and Its Inhibition by OTI-611 Impedes the DNA Damage Response and Induces PARthanatos

Autor: Rita Sala, Hector Esquer, Timothy Kellett, Jeffrey T. Kearns, Paul Awolade, Qiong Zhou, Daniel V. LaBarbera

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 16, p 8590 (2024)

The Chromodomain helicase DNA-binding protein 1-like (CHD1L) is a nucleosome remodeling enzyme, which plays a key role in chromatin relaxation during the DNA damage response. Genome editing has shown that deletion of CHD1L sensitizes cells to PARPi,

Externí odkaz: https://doaj.org/article/a7d02bfd3aee43318eedde87da7ac5f7

Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance (vol 48, pg 1131, 2016)

Autor: Secrier, Maria, Li, Xiaodun, De Silva, Nadeera, Eldridge, Matthew D, Contino, Gianmarco, Bornschein, Jan, MacRae, Shona, Grehan, Nicola, O'Donovan, Maria, Miremadi, Ahmad, Yang, Tsun-Po, Bower, Lawrence, Chettouh, Hamza, Crawte, Jason, Galeano-Dalmau, Nuria, Grabowska, Anna, Saunders, John, Underwood, Tim, Waddell, Nicola, Barbour, Andrew P, Nutzinger, Barbara, Achilleos, Achilleas, Edwards, Paul AW, Lynch, Andy G, Tavare, Simon, Fitzgerald, Rebecca C

lack of robust stratification methods. Whole-genome sequencing (WGS) analysis of 129 cases demonstrated that this is a heterogeneous cancer dominated by copy number alterations with frequent large-scale rearrangements. Co-amplification of receptor ty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0ec3c66e67f179ad16ef4384047fdd
https://www.repository.cam.ac.uk/handle/1810/279595

Prediction of the Mechanical Properties of Fibre-Reinforced Quarry Dust Concrete Using Response Surface and Artificial Neural Network Techniques

Autor: Jayaprakash Sridhar, Shanmugam Balaji, Dhanapal Jegatheeswaran, Paul Awoyera

Publikováno v: Advances in Civil Engineering, Vol 2023 (2023)

The focus of this study is to forecast the 28-day compressive strength and split tensile strength of concrete with various percentages of jute and coconut fibres mixed with quarry dust. The response surface methodology (RSM) and the artificial neural

Externí odkaz: https://doaj.org/article/15c601ac30e946b4867a7887666b1fb6