Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Paul A. Whetstone"'
Publikováno v:
Analytical and Bioanalytical Chemistry. 388:1643-1651
Autism is a complex neurodevelopmental disorder with unknown etiology. One hypothesis regarding etiology in autism is the "opioid peptide excess" theory that postulates that excessive amounts of exogenous opioid-like peptides derived from dietary pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546dcfbef02f58b5ba763b21cb47b4bd
https://doi.org/10.1007/s00216-007-1301-4
https://doi.org/10.1007/s00216-007-1301-4
Autor:
Claude F. Meares, W. Henry Benner, Paul A. Whetstone, Nicolas L. Young, Sarah M. Cheal, Susan Lee, Carlito B. Lebrilla
Publikováno v:
Journal of Proteome Research. 5:539-547
Protein oxidation is linked to cellular stress, aging, and disease. Protein oxidations that result in reactive species are of particular interest, since these reactive oxidation products may react with other proteins or biomolecules in an unmediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711312a9e6151dc0a80cb7b12772bc7c
https://doi.org/10.1021/pr050299q
https://doi.org/10.1021/pr050299q
Publikováno v:
Toxicon. 47:144-149
Scorpion venom is composed among other things of a large number of neurotoxic peptides affecting all major types of ion channels. The majority of the toxicity of the venom is attributed to the presence of these peptides. In our previous studies using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312a5cb9f833c81a52d393fa6d98d3cd
https://doi.org/10.1016/j.toxicon.2005.08.018
https://doi.org/10.1016/j.toxicon.2005.08.018
Autor:
Paul D. Jones, Bertold Hock, Nicola M. Wolf, Bruce D. Hammock, Paul A. Whetstone, Christophe Morisseau
Publikováno v:
Analytical Biochemistry. 343:66-75
Inhibition of the mammalian soluble epoxide hydrolase (sEH) is a promising new therapy in the treatment of disorders resulting from hypertension and vascular inflammation. A spectrophotometric assay (4-nitrophenyl-trans-2,3-epoxy-3-phenylpropyl carbo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b142500825e8c1491d9384e25617a9
https://doi.org/10.1016/j.ab.2005.03.041
https://doi.org/10.1016/j.ab.2005.03.041
Publikováno v:
Bioconjugate Chemistry. 15:647-657
Radioligand targeting of somatostatin receptor subtype 2 (sstr2)-positive tumors with synthetic somatostatin analogues such as octreotide is subject to improvement in tumor to nontumor biodistribution, in part because internalization of such somatost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387524eeabb205bab90165fbb1a2a7bb
https://doi.org/10.1021/bc049972c
https://doi.org/10.1021/bc049972c
Publikováno v:
Bioconjugate Chemistry. 15:3-6
Isotope-coded affinity tags (ICAT) represent an important new tool for the analysis of complex mixtures of proteins in living systems [Aebersold, R., and Mann, M. (2003) Nature, 422, 198-207]. We envisage an alternative protein-labeling technique bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae3159345be9868317dc3dab5c784b4
https://doi.org/10.1021/bc034150l
https://doi.org/10.1021/bc034150l
Publikováno v:
Journal of Molecular Recognition. 16:255-259
Here we review an approach to the design and production of antibody/ligand pairs for use in cell targeting procedures, to achieve functional affinity far greater than avidin/biotin. Using fundamental chemical principles, we have developed antibody/li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef016822b7dd40ab52a07eea263cc4e
https://doi.org/10.1002/jmr.634
https://doi.org/10.1002/jmr.634
Publikováno v:
Bioconjugate Chemistry. 15:1389-1391
Monoclonal antibody 2D12.5 binds DOTA chelates of all the rare earths with K(d) approximately 10(-)(8) M, making it useful for the capture of probe molecules with a variety of properties. To make 2D12.5 even more useful for biological applications, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7792d79ee5d002bf991d688ea0fd119c
https://doi.org/10.1021/bc049825e
https://doi.org/10.1021/bc049825e
Autor:
Craig E. Wheelock, Bruce D. Hammock, Paul A. Whetstone, David K. Wilson, Mark D. Wogulis, Shizuo G. Kamita, Andrew C. Hinton
Publikováno v:
Biochemistry. 45(13)
Juvenile hormone (JH) is an insect hormone containing an alpha,beta-unsaturated ester consisting of a small alcohol and long, hydrophobic acid. JH degradation is required for proper insect development. One pathway of this degradation is through juven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a92c88f17c3538fdc40f4d46fee7a9
https://pubmed.ncbi.nlm.nih.gov/16566578
https://pubmed.ncbi.nlm.nih.gov/16566578
Publikováno v:
Journal of inorganic biochemistry. 100(5-6)
Antibodies against metal chelates may potentially be used in biomedical applications such as targeted imaging and therapy of cancer. Highly specific monoclonal antibodies can be developed, but their binding strength needs to be maximized for them to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee04dc27382a8833709329884db11f89
https://pubmed.ncbi.nlm.nih.gov/16487590
https://pubmed.ncbi.nlm.nih.gov/16487590