Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Paul A. Voziyan"'
Autor:
Kerri J. Grove, Paul A. Voziyan, Jeffrey M. Spraggins, Suwan Wang, Paisit Paueksakon, Raymond C. Harris, Billy G. Hudson, Richard M. Caprioli
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 7, Pp 1375-1385 (2014)
Diabetic nephropathy (DN) is a major life-threatening complication of diabetes. Renal lesions affect glomeruli and tubules, but the pathogenesis is not completely understood. Phospholipids and glycolipids are molecules that carry out multiple cell fu
Externí odkaz:
https://doaj.org/article/27edb4b797ad4ea0ab3692cbc08b7021
Publikováno v:
Bone
The fracture resistance of cortical bone and matrix hydration are known to decline with advanced aging. However, the underlying mechanisms remain poorly understood, and so we investigated levels of matrix proteins and post-translational modifications
Autor:
Stephen G. Young, Ira Kurtz, Sergey Ivanov, Billy G. Hudson, Jeffrey H. Miner, Cuiwen He, Wenxin Song, Jonathan E. Zuckerman, Jeremy Bougoure, Haibo Jiang, Selene Colon, Caitlyn Tran, Gautam Bhave, Thomas A. Weston, Loren G. Fong, Paul Guagliardo, Paul A. Voziyan
Publikováno v:
Proc Natl Acad Sci U S A
Bromine and peroxidasin (an extracellular peroxidase) are essential for generating sulfilimine cross-links between a methionine and a hydroxylysine within collagen IV, a basement membrane protein. The sulfilimine cross-links increase the structural i
Publikováno v:
Bone. 110:204-214
Fracture risk increases as type 2 diabetes (T2D) progresses. With the rising incidence of T2D, in particular early-onset T2D, a representative pre-clinical model is needed to study mechanisms for treating or preventing diabetic bone disease. Towards
Publikováno v:
Heliyon, Vol 5, Iss 4, Pp e01497-(2019)
Heliyon
Heliyon
Countering the obesity pandemic will require better understanding of disease mechanisms and development of new diagnostic methods. Small molecule metabolites excreted in urine can be important biomarkers of disease progression and treatment. However,
Autor:
Calen J. Leverant, Jeffry S. Nyman, Saahit Adabala, Sasidhar Uppuganti, Mark D. Does, Paul A. Voziyan, Mustafa Unal, Mathilde Granke
Publikováno v:
JBMR Plus
JBMR Plus, Vol 3, Iss 6, Pp n/a-n/a (2019)
JBMR Plus, Vol 3, Iss 6, Pp n/a-n/a (2019)
Being predictors of the mechanical properties of human cortical bone, bound and pore water measurements by magnetic resonance (MR) imaging are being developed for the clinical assessment of fracture risk. While pore water is a surrogate of cortical b
Autor:
Dale R. Abrahamson, Billy G. Hudson, Jeffrey M. Spraggins, Megan M. Gessel, Richard M. Caprioli, Paul A. Voziyan
Publikováno v:
Lipids
Alport syndrome is caused by mutations in collagen IV that alter the morphology of renal glomerular basement membrane. Mutations result in proteinuria, tubulointerstitial fibrosis, and renal failure but the pathogenic mechanisms are not fully underst
Autor:
Billy G. Hudson, Ryan Bauer, Jarrod A. Smith, Sergey Ivanov, Paul A. Voziyan, Sergei P. Boudko, Sergei V. Chetyrkin
Publikováno v:
The Journal of Biological Chemistry
Our recent work identified a genetic variant of the α345 hexamer of the collagen IV scaffold that is present in patients with glomerular basement membrane diseases, Goodpasture's disease (GP) and Alport syndrome (AS), and phenocopies of AS in knock-
Autor:
George Haddad, Charles D. Pusey, Agnes B. Fogo, Dale R. Abrahamson, Rudolf P. Wüthrich, Clifford E. Kashtan, Alicia Simmons, Paul A. Voziyan, Fernando C. Fervenza, Sergei P. Boudko, Timo Wagner, Zhao Wei Cui, A. Richard Kitching, Raymond C. Harris, Eric Delpire, Andreas D. Kistler, Johan M. Lorenzen, Ming-Hui Zhao, Aaron L. Fidler, Sergei V. Chetyrkin, Ariana Gaspert, Carsten Bergmann, Oliver Gross, Billy G. Hudson, Maik Grohmann, Marten Segelmark, Harald Seeger, Elena Pokidysheva, Stephen P. McAdoo, Vadim Pedchenko
Publikováno v:
The Journal of Biological Chemistry
Diseases of the glomerular basement membrane (GBM), such as Goodpasture’s disease (GP) and Alport syndrome (AS), are a major cause of chronic kidney failure and an unmet medical need. Collagen IVα345 is an important architectural element of the GB
Autor:
Paul A. Voziyan, Dianne O’Neal, Amy Creecy, Alyssa R. Merkel, Alexander J. Makowski, Jeffry S. Nyman, Sasidhar Uppuganti, Mathilde Granke
Publikováno v:
Calcified Tissue International. 99:289-301
Individuals with type 2 diabetes (T2D) have a higher fracture risk compared to non-diabetics, even though their areal bone mineral density is normal to high. Identifying the mechanisms whereby diabetes lowers fracture resistance requires well-charact