Zobrazeno 1 - 10
of 212
pro vyhledávání: '"Paul A. Trainor"'
Autor:
Natalia A. Shylo, Sarah E. Smith, Andrew J. Price, Fengli Guo, Melainia McClain, Paul A. Trainor
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
The ancestral mode of left-right (L-R) patterning involves cilia in the L-R organizer. However, the mechanisms regulating L-R patterning in non-avian reptiles remains an enigma, since most squamate embryos are undergoing organogenesis at oviposition.
Externí odkaz:
https://doaj.org/article/58335c0b68804e32a7a620312ec8d164
Autor:
Qi Wang, Lin Xu, Jiro Miura, Mithun Kumar Saha, Yume Uemura, Lisa L. Sandell, Paul A. Trainor, Takashi Yamashiro, Hiroshi Kurosaka
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The first and second branchiomeric (branchial arch) muscles are craniofacial muscles that derive from branchial arch mesoderm. In mammals, this set of muscles is indispensable for jaw movement and facial expression. Defects during embryonic developme
Externí odkaz:
https://doaj.org/article/c3c4a06d98584fc3b3a609d7349fe001
Autor:
Sharien Fitriasari, Paul A. Trainor
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Craniofacial malformations are among the most common birth defects in humans and they often have significant detrimental functional, aesthetic, and social consequences. To date, more than 700 distinct craniofacial disorders have been described. Howev
Externí odkaz:
https://doaj.org/article/b5ccfb8035954735a528324224d87d0d
Autor:
Soma Dash, Shachi Bhatt, Lisa L. Sandell, Christopher W. Seidel, Youngwook Ahn, Robb E. Krumlauf, Paul A. Trainor
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Development of the vertebrate head is a complex and dynamic process, which requires integration of all three germ layers and their derivatives. Of special importance are ectoderm-derived cells that form the cranial placodes, which then differentiate
Externí odkaz:
https://doaj.org/article/8bc329ed86464cc588629b2338774dab
Autor:
Alexios A. Panoutsopoulos, Angelo Harlan De Crescenzo, Albert Lee, Amelia MacKenzie Lu, Adam P. Ross, Laura N. Borodinsky, Ralph Marcucio, Paul A. Trainor, Konstantinos S. Zarbalis
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Neural crest cells (NCCs) comprise a transient progenitor cell population of neuroepithelial origin that contributes to a variety of cell types throughout vertebrate embryos including most mesenchymal cells of the cranial and facial structures. Conse
Externí odkaz:
https://doaj.org/article/ee23303e1c1a4a44a8dec0dc3164c2e5
Autor:
Qi Wang, Hiroshi Kurosaka, Masataka Kikuchi, Akihiro Nakaya, Paul A. Trainor, Takashi Yamashiro
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 10 (2019)
Cleft palate (CP) is one of the most common congenital craniofacial anomalies in humans and can be caused by either single or multiple genetic and environmental factor(s). With respect to environmental factors, excessive intake of vitamin A during ea
Externí odkaz:
https://doaj.org/article/4701d9202f45446cb1ace69492effb80
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The TCOF1 gene is mutated in Treacher Collin's syndrome, a congenital craniofacial syndrome. Here, the authors show that Tcof1loss-of-function results in oxidative stress induced DNA damage and neuroepithelial cell death, and addition of antioxidants
Externí odkaz:
https://doaj.org/article/0c06c33ffc524a02843d403e11f7891b
Autor:
Thomas J. Cunningham, Xianling Zhao, Lisa L. Sandell, Sylvia M. Evans, Paul A. Trainor, Gregg Duester
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1503-1511 (2013)
The vitamin A metabolite retinoic acid (RA) provides patterning information during vertebrate embryogenesis, but the mechanism through which RA influences limb development is unclear. During patterning of the limb proximodistal axis (upper limb to di
Externí odkaz:
https://doaj.org/article/bb278ac125684fef917d7cecbac33d7c
Autor:
Takashi Yasukawa, Shachi Bhatt, Tamotsu Takeuchi, Junya Kawauchi, Hidehisa Takahashi, Aya Tsutsui, Takuya Muraoka, Makoto Inoue, Masayuki Tsuda, Shigetaka Kitajima, Ronald C. Conaway, Joan W. Conaway, Paul A. Trainor, Teijiro Aso
Publikováno v:
Cell Reports, Vol 2, Iss 5, Pp 1129-1136 (2012)
Elongin A increases the rate of RNA polymerase II (pol II) transcript elongation by suppressing transient pausing by the enzyme. Elongin A also acts as a component of a cullin-RING ligase that can target stalled pol II for ubiquitylation and proteaso
Externí odkaz:
https://doaj.org/article/2a853751c7664e919d8d78e9e8cef278
Autor:
Paul A. Trainor
Publikováno v:
The Scientific World Journal, Vol 3, Pp 240-264 (2003)
Craniofacial development is an extraordinarily complex process requiring the orchestrated integration of multiple specialized tissues such as the surface ectoderm, neural crest, mesoderm, and pharyngeal endoderm in order to generate the central and p
Externí odkaz:
https://doaj.org/article/4879bf5254ba4c9995a5dfb1e2df8e6a