Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Paul A. Steimle"'
Autor:
Miho Iijima, Yu Wang, Hiromi Sesaki, Christopher A. Ross, Paul A. Steimle, Thomas T. Egelhoff, Douglas N. Robinson, Yixin Ren
Publikováno v:
Molecular Biology of the Cell
This work shows that huntingtin protein (Htt) regulates the phosphorylation status of myosin II during chemotaxis and cytokinesis through protein phosphatase 2A (PP2A). Our findings provide novel insights into the physiological function of Htt and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a337ef7491d087984594b619614f5930
https://doi.org/10.1091/mbc.e10-11-0926
https://doi.org/10.1091/mbc.e10-11-0926
Autor:
Paul A. Steimle, Subhanjan Mondal, Francisco Rivero, Berthold Gassen, Angelika A. Noegel, Deenadayalan Bakthavatsalam
Publikováno v:
The Journal of Cell Biology
Ras guanine nucleotide exchange factor (GEF) Q, a nucleotide exchange factor from Dictyostelium discoideum, is a 143-kD protein containing RasGEF domains and a DEP domain. We show that RasGEF Q can bind to F-actin, has the potential to form complexes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76cb5e922a1d17fcf81f62867963bc13
http://europepmc.org/articles/PMC2396803
http://europepmc.org/articles/PMC2396803
Publikováno v:
Biochemical and Biophysical Research Communications. 345:516-522
Naringenin is a flavanone compound that alters critical cellular processes such as cell multiplication, glucose uptake, and mitochondrial activity. In this study, we used the social amoeba, Dictyostelium discoideum, as a model system for examining th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39cb7fce7f1f3c6572120d08d6e9f3be
https://doi.org/10.1016/j.bbrc.2006.04.047
https://doi.org/10.1016/j.bbrc.2006.04.047
Publikováno v:
Journal of Biological Chemistry. 280:2879-2887
Studies in Dictyostelium discoideum have established that the cycle of myosin II bipolar filament assembly and disassembly controls the temporal and spatial localization of myosin II during critical cellular processes, such as cytokinesis and cell lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6398867ce394c8ab4bd1708264b93aaa
https://doi.org/10.1074/jbc.m410803200
https://doi.org/10.1074/jbc.m410803200
Publikováno v:
Journal of Biological Chemistry. 276:17836-17843
Dictyostelium myosin II heavy chain kinase A (MHCK A), MHCK B, and MHCK C contain a novel type of protein kinase catalytic domain that displays no sequence identity to the catalytic domain present in conventional serine, threonine, and/or tyrosine pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89371418760052e77f546837a6997ac8
https://doi.org/10.1074/jbc.m009366200
https://doi.org/10.1074/jbc.m009366200
Autor:
Mark V. Polyakov, Quint G. Medley, Graham P. Côté, Thomas T. Egelhoff, Shigehiko Yumura, Paul A. Steimle, Brian Leppert
Publikováno v:
Current Biology. 11:708-713
Nonmuscle myosin II plays fundamental roles in cell body translocation during migration and is typically depleted or absent from actin-based cell protrusions such as lamellipodia, but the mechanisms preventing myosin II assembly in such structures ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa493b28b581384ecdd4f4b30c8d9b9
https://doi.org/10.1016/s0960-9822(01)00182-8
https://doi.org/10.1016/s0960-9822(01)00182-8
Publikováno v:
Journal of Biological Chemistry. 276:6853-6860
Myosin heavy chain kinase (MHCK) A phosphorylates mapped sites at the C-terminal tail of Dictyostelium myosin II heavy chain, driving disassembly of myosin filaments both in vitro and in vivo. MHCK A is organized into three functional domains that in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c65729e62b621d554c52cc379c6f3f
https://doi.org/10.1074/jbc.m008992200
https://doi.org/10.1074/jbc.m008992200
Autor:
P. Timothy Macechko, Paul A. Steimle, Timothy A. Paget, Craig D. Karr, Dorota A. Bulik, Edward L. Jarroll, J. P. Kamerling, Stanley L. Erlandsen, Johannes F.G. Vliegenthart, Harry van Keulen, Gerrit J. Gerwig
Publikováno v:
The Journal of Eukaryotic Microbiology. 48:22-26
Giardia intestinalis trophozoites encyst when they are exposed to bile. During encystment, events related to the inducible synthesis of a novel N-acetyl-d-galactosamine (GalNAc) homopolymer, occur. Within the first 6 h of encystment, mRNA for glucosa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::379186f3f203fd7ff048e5ec151f6065
https://doi.org/10.1111/j.1550-7408.2001.tb00412.x
https://doi.org/10.1111/j.1550-7408.2001.tb00412.x
Purification and characterization of encystment-induced glucosamine 6-phosphate isomerase in Giardia
Publikováno v:
Molecular and Biochemical Parasitology. 84:149-153
Giardia intestinalis encystment results in the incorporation of galactosamine (GalN) (a cyst- wall specific sugar) into outer cyst wall filaments [1,2]. GalN is synthesized during encystment from endogenous glucose by an inducible enzyme pathway [3]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed083fb26a80f3441c521e2c5551c3b
https://doi.org/10.1016/s0166-6851(96)02790-9
https://doi.org/10.1016/s0166-6851(96)02790-9
Autor:
Amanda Scherer, Deborah Wessels, David R. Soll, Kristen Wood, Thomas T. Egelhoff, Spencer Kuhl, Paul A. Steimle, Brett Hanson, Daniel F. Lusche
Publikováno v:
Journal of Cell Science.
Behavioral analyses of the deletion mutants of the four known myosin II heavy chain (Mhc) kinases of Dictyostelium discoideum revealed that all play a minor role in the efficiency of basic cell motility, but none play a role in chemotaxis in a spatia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22fa765af491a855d1fbe0186382ed29
https://doi.org/10.1242/jcs.112474
https://doi.org/10.1242/jcs.112474