Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Paul A. Sigala"'
Autor:
Megan Okada, Paul A. Sigala
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10 (2023)
Externí odkaz:
https://doaj.org/article/ba3b667a556144b49eceb9f5b3b9f0d4
Autor:
Megan Okada, Krithika Rajaram, Russell P Swift, Amanda Mixon, John Alan Maschek, Sean T Prigge, Paul A Sigala
Publikováno v:
eLife, Vol 11 (2022)
Isopentenyl pyrophosphate (IPP) is an essential metabolic output of the apicoplast organelle in Plasmodium falciparum malaria parasites and is required for prenylation-dependent vesicular trafficking and other cellular processes. We have elucidated a
Externí odkaz:
https://doaj.org/article/d6c5aa846c6547d3ac466ffd5e45ea8e
Autor:
Seyi Falekun, Jaime Sepulveda, Yasaman Jami-Alahmadi, Hahnbeom Park, James A Wohlschlegel, Paul A Sigala
Publikováno v:
eLife, Vol 10 (2021)
Most eukaryotic cells retain a mitochondrial fatty acid synthesis (FASII) pathway whose acyl carrier protein (mACP) and 4-phosphopantetheine (Ppant) prosthetic group provide a soluble scaffold for acyl chain synthesis and biochemically couple FASII a
Externí odkaz:
https://doaj.org/article/e26ae9a9b2774268824fb1a004ffa0c3
Publikováno v:
eLife, Vol 9 (2020)
Doxycycline (DOX) is a key antimalarial drug thought to kill Plasmodium parasites by blocking protein translation in the essential apicoplast organelle. Clinical use is primarily limited to prophylaxis due to delayed second-cycle parasite death at 1
Externí odkaz:
https://doaj.org/article/c357fa8c47ce43b2acf3f9e12132fa51
Autor:
Tanya J. Espino-Sanchez, Henry Wienkers, Rebecca G. Marvin, Shai-anne Nalder, Aldo E. García-Guerrero, Peter E. VanNatta, Yasaman Jami-Alahmadi, Amanda Mixon Blackwell, Frank G. Whitby, James A. Wohlschlegel, Matthew T. Kieber-Emmons, Christopher P. Hill, Paul A. Sigala
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The mitochondrial electron transport chain (ETC) of Plasmodium malaria parasites is a major antimalarial drug target, but critical cytochrome (cyt) functions remain unstudied and enigmatic. Parasites express two distinct cyt c homologs ( c and c -2)
Autor:
Tanya J. Espino-Sanchez, Henry Wienkers, Rebecca G. Marvin, Shai-anne Nalder, Aldo E. García-Guerrero, Peter E. VanNatta, Yasaman Jami-Alahmadi, Amanda Mixon Blackwell, Frank G. Whitby, James A. Wohlschlegel, Matthew T. Kieber-Emmons, Christopher P. Hill, Paul A. Sigala
Publikováno v:
bioRxiv
The mitochondrial electron transport chain (ETC) ofPlasmodiummalaria parasites is a major antimalarial drug target, but critical cytochrome functions remain unstudied and enigmatic. Parasites express two distinct cytchomologs (candc-2) with unusually
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3814302e47517bd5ef343f12627cd7f
https://europepmc.org/articles/PMC9900762/
https://europepmc.org/articles/PMC9900762/
Publikováno v:
ACS omega. 7(45)
Viscoelastic flow has been widely used in microfluidic particle separation processes, in which particles get focused on the channel center in diluted viscoelastic flow. In this paper, the transition from single-stream focusing to multiple-streams foc
Autor:
Daniel E Goldberg, Paul A Sigala
Publikováno v:
PLoS Pathogens, Vol 13, Iss 9, p e1006511 (2017)
Externí odkaz:
https://doaj.org/article/523d4fb345c34ea380bbe2547ae5d8cb