Zobrazeno 1 - 10
of 2 142
pro vyhledávání: '"Paul A. Richardson"'
Autor:
Paul G. Richardson, Aurore Perrot, Joseph Mikhael, Thomas Martin, Meral Beksac, Ivan Spicka, Marcelo Capra, Mattia D’Agostino, Pieter Sonneveld, Kamlesh Bisht, Taro Fukao, Rick Zhang, Keisuke Tada, Christina Tekle, Sandrine Macé, Zandra Klippel, Helgi van de Velde, Philippe Moreau
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The International Staging System for multiple myeloma recently underwent a second revision (R2-ISS) to include gain/amplification of 1q21 and account for the additive prognostic significance of multiple high-risk features. The phase 3 ICARIA
Externí odkaz:
https://doaj.org/article/9b635da01c1d4b89909d399fd5c7a1f2
Autor:
Charlotte Pawlyn, Fredrik H. Schjesvold, David A. Cairns, L. J. Wei, Faith Davies, Omar Nadeem, Haifaa Abdulhaq, Maria-Victoria Mateos, Jacob Laubach, Katja Weisel, Heinz Ludwig, S. Vincent Rajkumar, Pieter Sonneveld, Graham Jackson, Gareth Morgan, Paul G. Richardson
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Measurement of overall survival (OS) remains the gold standard for interpreting the impact of new therapies for multiple myeloma in phase 3 trials. However, as outcomes have improved, it is increasingly challenging to use OS as the primary e
Externí odkaz:
https://doaj.org/article/186d300a7c3d4b47adaec4bd25b20ac5
Autor:
Radhika Narain, Ian Nessler, Paul L. Richardson, Jamie E. Erickson, Yuzhen Wang, Jacqueline Ferri, Heather L. Knight, Shaughn H. Bryant, Lucy A. Phillips, Liang Zhang, Soumya Mitra
Publikováno v:
npj Imaging, Vol 2, Iss 1, Pp 1-11 (2024)
Abstract In this work, the impact of physicochemical modifications on pharmacokinetics and in vivo targeting of a small molecule fibroblast activation protein inhibitor (FAPI) imaging ligand in a murine model of rheumatoid arthritis was evaluated. Wh
Externí odkaz:
https://doaj.org/article/821384118fe54bc18bf98f999d4cbfe8
Autor:
Ajai Chari, Jonathan L. Kaufman, Jacob Laubach, Douglas W. Sborov, Brandi Reeves, Cesar Rodriguez, Rebecca Silbermann, Luciano J. Costa, Larry D. Anderson, Nitya Nathwani, Nina Shah, Naresh Bumma, Sarah A. Holstein, Caitlin Costello, Andrzej Jakubowiak, Tanya M. Wildes, Robert Z. Orlowski, Kenneth H. Shain, Andrew J. Cowan, Huiling Pei, Annelore Cortoos, Sharmila Patel, Thomas S. Lin, Peter M. Voorhees, Saad Z. Usmani, Paul G. Richardson
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The randomized, phase 2 GRIFFIN study (NCT02874742) evaluated daratumumab plus lenalidomide/bortezomib/dexamethasone (D-RVd) in transplant-eligible newly diagnosed multiple myeloma (NDMM). We present final post hoc analyses (median follow-up
Externí odkaz:
https://doaj.org/article/bb6796db0ba84a22b84787f34a884f56
Autor:
Amber J Normann, Clifton C Mo, Rebekah L Wilson, Michelle Perez, Corey Cutler, Hajime Uno, LaDora V Thompson, Tina L Skinner, Paul G Richardson, Catherine R Marinac, Christina M Dieli-Conwright
Publikováno v:
JMIR Research Protocols, Vol 13, p e64905 (2024)
BackgroundMuscle mass and strength are severely compromised in patients diagnosed with multiple myeloma, such that the risk of poor overall survival increases as the prevalence of low muscle mass, also known as sarcopenia, increases. Additionally, at
Externí odkaz:
https://doaj.org/article/f72cfbbe0fc149ab9a3a21c8f9a4f789
Autor:
Yuxin Liu, Clifton Mo, Monique Hartley-Brown, Shonali Midha, Adam S. Sperling, Giada Bianchi, Omar Nadeem, Betsy O’Donnell, Jacob Laubach, Paul G. Richardson
Publikováno v:
healthbook TIMES. Oncology Hematology (2024)
Over the past two decades, significant progress has been made in the management of multiple myeloma (MM), leading to the development of novel therapeutic approaches and treatment regimens to improve patient outcomes. In patients with newly diagnosed
Externí odkaz:
https://doaj.org/article/787fc8e190764ab687af8cf0e9b9a3b8
Autor:
Paul G. Richardson
Publikováno v:
Hemato, Vol 5, Iss 2, Pp 144-156 (2024)
High-dose melphalan (HDM) plus autologous stem cell transplant (ASCT) remains a standard-of-care treatment approach for eligible patients with newly diagnosed multiple myeloma (NDMM) based on demonstrated superiority in terms of progression-free surv
Externí odkaz:
https://doaj.org/article/a486f64b32994ea082b920ff40830de1
Autor:
Natalie S. Callander, Rebecca Silbermann, Jonathan L. Kaufman, Kelly N. Godby, Jacob Laubach, Timothy M. Schmidt, Douglas W. Sborov, Eva Medvedova, Brandi Reeves, Binod Dhakal, Cesar Rodriguez, Saurabh Chhabra, Ajai Chari, Susan Bal, Larry D. Anderson, Bhagirathbhai R. Dholaria, Nitya Nathwani, Parameswaran Hari, Nina Shah, Naresh Bumma, Sarah A. Holstein, Caitlin Costello, Andrzej Jakubowiak, Tanya M. Wildes, Robert Z. Orlowski, Kenneth H. Shain, Andrew J. Cowan, Huiling Pei, Annelore Cortoos, Sharmila Patel, Thomas S. Lin, Smith Giri, Luciano J. Costa, Saad Z. Usmani, Paul G. Richardson, Peter M. Voorhees
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract In the MASTER study (NCT03224507), daratumumab+carfilzomib/lenalidomide/dexamethasone (D-KRd) demonstrated promising efficacy in transplant-eligible newly diagnosed multiple myeloma (NDMM). In GRIFFIN (NCT02874742), daratumumab+lenalidomide/
Externí odkaz:
https://doaj.org/article/ebc38d6b2c3c4c4a957f6410c2bc2f56
Autor:
Peter Kovar, Paul L Richardson, Alla Korepanova, Gustavo A Afanador, Vladimir Stojkovic, Tao Li, Michael R Schrimpf, Teresa I Ng, David A Degoey, Sujatha M Gopalakrishnan, Jun Chen
Publikováno v:
SLAS Discovery, Vol 29, Iss 6, Pp 100179- (2024)
The SARS-CoV-2 main protease (Mpro) is essential for viral replication because it is responsible for the processing of most of the non-structural proteins encoded by the virus. Inhibition of Mpro prevents viral replication and therefore constitutes a
Externí odkaz:
https://doaj.org/article/0e0b9455143c4b4e883db21e8a29ec2c
Autor:
Annalisa Ruggeri, Francesco Corrado, Antonio Voza, Lee-Jen Wei, Gloria Catalano, Carmine Liberatore, Rosamaria Nitti, Carlo Fedeli, Alessandro Bruno, Eleonora Calabretta, Fabio Giglio, Fabio Sciutti, Francesca Lunghi, Giovanni Landoni, Alessio Aghemo, Massimo Iacobelli, Patrizia Rovere Querini, Paul G. Richardson, Andrea Assanelli, Jacopo Peccatori, Fabio Ciceri, Carmelo Carlo-Stella
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
The coronavirus disease 2019 (COVID-19) pandemic led to an unprecedented burden on healthcare systems around the world and a severe global socioeconomic crisis, with more than 750 million confirmed cases and at least 7 million deaths reported by 31st
Externí odkaz:
https://doaj.org/article/e626a6cf241d4feb8370a979f32275f0