Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Paul A. Randazzo"'
Autor:
Sarah M. Hammoudeh, Yeap Ng, Bih-Rong Wei, Thomas D. Madsen, Mukesh P. Yadav, R. Mark Simpson, Roberto Weigert, Paul A. Randazzo
Publikováno v:
Cell Reports: Methods, Vol 4, Iss 7, Pp 100802- (2024)
Summary: PAX3/7 fusion-negative rhabdomyosarcoma (FN-RMS) is a childhood mesodermal lineage malignancy with a poor prognosis for metastatic or relapsed cases. Limited understanding of advanced FN-RMS is partially attributed to the absence of sequenti
Externí odkaz:
https://doaj.org/article/de21190a5a7242a48483a45be5f5303c
Autor:
Yue Zhang, Olivier Soubias, Shashank Pant, Frank Heinrich, Alexander Vogel, Jess Li, Yifei Li, Luke A. Clifton, Sebastian Daum, Kirsten Bacia, Daniel Huster, Paul A. Randazzo, Mathias Lösche, Emad Tajkhorshid, R. Andrew Byrd
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract ADP-ribosylation factor 1 (Arf1) interacts with multiple cellular partners and membranes to regulate intracellular traffic, organelle structure and actin dynamics. Defining the dynamic conformational landscape of Arf1 in its active form, whe
Externí odkaz:
https://doaj.org/article/e58ab08c95164c4ba75fd58fe4fa9a1e
Autor:
Saumil Sethna, Patrick A. Scott, Arnaud P. J. Giese, Todd Duncan, Xiaoying Jian, Sheikh Riazuddin, Paul A. Randazzo, T. Michael Redmond, Steven L. Bernstein, Saima Riazuddin, Zubair M. Ahmed
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Age-related macular degeneration (AMD) has been connected to deficits in autophagy. Here, the authors demonstrate, in mice and dry-AMD patient samples, that calcium and integrin binding protein 2 (CIB2) regulates Rheb-mTORC1 signaling axis, and subse
Externí odkaz:
https://doaj.org/article/28f9c426a95d413a8bcf70e1675378bc
Publikováno v:
iScience, Vol 22, Iss , Pp 166-180 (2019)
Summary: ASAP1 is a multi-domain ArfGAP that controls cell migration, spreading, and focal adhesion dynamics. Although its GAP activity contributes to remodeling of the actin cytoskeleton, it does not fully explain all cellular functions of ASAP1. He
Externí odkaz:
https://doaj.org/article/c4b1a2db7655427ca55550905863ca8b
Autor:
Marielle E. Yohe, Lisa M. Miller Jenkins, Paul A. Randazzo, Deborah K. Morrison, Dan L. Sackett, Craig J. Thomas, Robert W. Robey, Simone Difilippantinio, Alexander E. Kelly, Xiaoling Luo, Jinqui-Qiu Chen, Christine M. Heske, Arnulfo Mendoza, Christina M. Robinson, Kristine A. Isanogle, Devorah C. Gallardo, Kelli M. Wilson, Gaelyn C. Lyons, Ruibai Luo, Edjay R. Hernandez, Xiaolin Wan, Joshua T. Kowalczyk
Supplemental tables 1-3, supplemental figure legends, supplemental figures 1-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5020c92196b772fac506276bb9a56784
https://doi.org/10.1158/1535-7163.22521423.v1
https://doi.org/10.1158/1535-7163.22521423.v1
Autor:
Eric M. Rosenberg, Xiaoying Jian, Olivier Soubias, Hye-Young Yoon, Mukesh P. Yadav, Sarah Hammoudeh, Sandeep Pallikkuth, Itoro Akpan, Pei-Wen Chen, Tapan K. Maity, Lisa M. Jenkins, Marielle E. Yohe, R. Andrew Byrd, Paul A. Randazzo
Publikováno v:
Journal of Biological Chemistry. 299:102992
Publikováno v:
iScience, Vol 22, Iss, Pp 166-180 (2019)
iScience
iScience
Summary ASAP1 is a multi-domain ArfGAP that controls cell migration, spreading, and focal adhesion dynamics. Although its GAP activity contributes to remodeling of the actin cytoskeleton, it does not fully explain all cellular functions of ASAP1. Her
Publikováno v:
The Journal of biological chemistry. 298(3)
Actin filament maintenance is critical for both normal cell homeostasis and events associated with malignant transformation. The ADP-ribosylation factor GTPase-activating protein ASAP1 regulates the dynamics of filamentous actin-based structures, inc
Autor:
Hye-Young Yoon, Ben Y. Maron, Sofia Girald-Berlingeri, Anjelika Gasilina, Josephine C. Gollin, Xiaoying Jian, Itoro Akpan, Marielle E. Yohe, Paul A. Randazzo, Pei-Wen Chen
Publikováno v:
Biochimica et biophysica acta. Molecular cell research. 1869(8)
Osteosarcoma (OS) and Pax-Foxo1 fusion negative rhabdomyosarcoma (FN-RMS) are pediatric sarcomas with poor prognoses in patients with advanced disease. In both malignancies, an actin binding protein has been linked to poor prognosis. Integrin adhesio
Autor:
Junya Wada, Udumbara Rathnayake, Lisa M. Jenkins, Avinash Singh, Moosa Mohammadi, Ettore Appella, Paul A. Randazzo, Lawrence E. Samelson
Publikováno v:
The Journal of biological chemistry. 298(3)
Activation of T cells upon engagement of the T cell antigen receptor rapidly leads to a number of phosphorylation and plasma membrane recruitment events. For example, translocation of phospholipase-Cγ1 (PLC-γ1) to the plasma membrane and its associ